Patient Oriented Research in Gastrointestinal Cancer Screening

描述（由申请人提供）：该K24中期职业研究者奖将促进培训GI研究员参加GI流行病学专业培训计划（T32-DK062708），指导申请/完成职业发展奖励的初级教师，以及在NIH和VA资助的GI癌症筛查试验中以患者为导向的研究。“未来成功的最佳预测者可能是过去的成就。”作为密歇根大学GI流行病学培训项目的首席研究员和主任，我已经成功地指导了100%的参与者进入学术医学领域。在我们的项目中，GI研究员完成临床研究设计和统计分析硕士课程，并接受高级研究员的广泛指导和监督，这有助于他们成功过渡到学术医学。我还指导初级教师在完成培训项目后获得K23、R21和其他职业发展奖项。除了为指导学员和初级教师提供保护时间外，这笔资助还将促进我的研究职业目标：识别胃肠道癌症的危险因素和开发更有效的胃肠道癌症筛查工具。我已经成功完成了K23和R21的资助，并发表了多篇论文。目前，我是va资助的一项关于应用家族史和基因组工具来改善结直肠癌（CRC）筛查的中心项目的负责人，也是一项U54项目的共同研究者，该项目正在开发用于在内镜下识别食管和结肠发育不良的体内生物标志物。这些正在进行的研究项目将为实习生和初级教师提供一个发展自己研究的平台。此外，密歇根大学提供了一个优秀的环境和资源，包括我们的GI流行病学专业培训计划，我们的nih资助的密歇根临床研究单位，va资助的卓越实践管理和成果研究中心，以及我们的公共卫生学院的临床流行病学专业硕士课程。不幸的是，GI研究员和初级教员的指导是没有资金的。目前的U54和VA资金支付研究用品，设备和辅助人员，但提供的资金不足以保护我的时间，以病人为导向的研究和指导。这个K24奖将为实现我的指导和研究目标提供必要的支持。

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award will facilitate training GI fellows participating in a specialized Training Program in GI Epidemiology (T32-DK062708), mentoring of junior faculty applying for/completing career development awards, and performance of patient-oriented research in GI cancer screening trials funded by NIH and VA. "The best predictor of future success may be past achievement." As principal investigator and Director of the U. of Michigan Training Program in GI Epidemiology, I have successfully mentored 100% of the participants to careers in academic medicine. In our program, GI fellows complete a Master's program in Clinical Research Design and Statistical Analysis and undergo extensive mentoring and supervision from senior investigators which contributes to their successful transition to academic medicine. I also mentor junior faculty on K23, R21, and other career development awards after they complete this training program. In addition to providing protected time to mentor trainees and junior faculty, this grant will also facilitate my research career objective: identification of risk factors for GI cancer and development of more effective tools for GI cancer screening. I have successfully completed K23 and R21 grants which have led to multiple publications. Currently, I am PI of a VA-funded Center grant about the application of family history and genomic tools to improve colorectal cancer (CRC) screening, and co-investigator of a U54 grant developing in vivo biomarkers for the identification of dysplasia in the esophagus and colon during endoscopy. These on-going research projects will provide a platform for trainees and junior faculty to develop their own research. Also, the U. of Michigan provides an outstanding environment and resources, including our specialized Training Program in GI Epidemiology, our NIH-funded Michigan Clinical Research Unit, VA-funded Center of Excellence for Practice Management and Outcomes Research, and our School of Public Health's specialized Master's Programs in Clinical Epidemiology. Unfortunately, mentoring of GI fellows and junior faculty is unfunded. The current U54 and VA funding pay for research supplies, equipment, and ancillary personnel, but provides inadequate funding to protect my time for patient-oriented research and mentorship. This K24 award will provide essential support to achieve my mentorship and research goals. PUBLIC HEALTH RELEVANCE: This award will provide support to mentor young investigators performing patient-oriented GI cancer screening research. It will also provide the candidate to complete studies on this topic. The proposed studies will improve screening techniques for Barrett's esophagus and esophageal adenocarcinoma, facilitate appropriate screening of patients with a family history of colorectal cancer, identify modifiable risk factors for colon adenomas, and identify new tools to detect dysplasia in the gastrointestinal tract.