Patient Oriented Research in Gastrointestinal Cancer Screening

以患者为导向的胃肠癌筛查研究

• 批准号: 8321654
• 负责人: PHILIP S SCHOENFELD
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321654
• 关键词: Achievement; Alcohol consumption; Algorithms; Area; Award; Barrett Esophagus; Binding; Biological Markers; Blood; Body mass index; Caliber; Clinic; Clinical; Clinical Protocols; Clinical Research; Colon; Colon Carcinoma; Colonic Adenoma; Colonoscopy; Colorectal Cancer; Confocal Microscopy; Data; Databases; Detection; Development; Diagnosis; Dietary Questionnaires; Dysplasia; Endoscopy; Environment; Epidemiology; Equipment and Supplies; Esophageal Adenocarcinoma; Esophagus; Faculty; Family history of; First Degree Relative; Fluorescence; Funding; Future; Gastrointestinal tract structure; Gender; Genomics; Goals; Grant; Health Services Research; Heme Iron; Human Resources; Hyperplastic Polyp; Image; Individual; Intake; Iron; K-Series Research Career Programs; Label; Lesion; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Measures; Meat; Medical; Medicine; Mentors; Mentorship; Michigan; Mid-Career Clinical Scientist Award (K24); Molecular Weight; Mucous Membrane; National Institute of Diabetes and Digestive and Kidney Diseases; Neoplasms; Non-Steroidal Anti-Inflammatory Agents; Outcomes Research; Participant; Patients; Penetration; Peptides; Performance; Physical activity; Plasma; Practice Management; Prevalence; Principal Investigator; Protocols documentation; Public Health Schools; Publications; Race; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Screening for cancer; Screening procedure; Study Section; Supervision; System; Techniques; Time; Tissue Banking; Tissue Banks; Tobacco use; Topical application; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Woman; adenoma; adipokines; career; clinical epidemiology; colorectal cancer screening; high risk; image registration; improved; in vivo; modifiable risk; older patient; optical imaging; patient oriented; patient oriented research; programs; public health relevance; success; tool

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award will facilitate training GI fellows participating in a specialized Training Program in GI Epidemiology (T32-DK062708), mentoring of junior faculty applying for/completing career development awards, and performance of patient-oriented research in GI cancer screening trials funded by NIH and VA. "The best predictor of future success may be past achievement." As principal investigator and Director of the U. of Michigan Training Program in GI Epidemiology, I have successfully mentored 100% of the participants to careers in academic medicine. In our program, GI fellows complete a Master's program in Clinical Research Design and Statistical Analysis and undergo extensive mentoring and supervision from senior investigators which contributes to their successful transition to academic medicine. I also mentor junior faculty on K23, R21, and other career development awards after they complete this training program. In addition to providing protected time to mentor trainees and junior faculty, this grant will also facilitate my research career objective: identification of risk factors for GI cancer and development of more effective tools for GI cancer screening. I have successfully completed K23 and R21 grants which have led to multiple publications. Currently, I am PI of a VA-funded Center grant about the application of family history and genomic tools to improve colorectal cancer (CRC) screening, and co-investigator of a U54 grant developing in vivo biomarkers for the identification of dysplasia in the esophagus and colon during endoscopy. These on-going research projects will provide a platform for trainees and junior faculty to develop their own research. Also, the U. of Michigan provides an outstanding environment and resources, including our specialized Training Program in GI Epidemiology, our NIH-funded Michigan Clinical Research Unit, VA-funded Center of Excellence for Practice Management and Outcomes Research, and our School of Public Health's specialized Master's Programs in Clinical Epidemiology. Unfortunately, mentoring of GI fellows and junior faculty is unfunded. The current U54 and VA funding pay for research supplies, equipment, and ancillary personnel, but provides inadequate funding to protect my time for patient-oriented research and mentorship. This K24 award will provide essential support to achieve my mentorship and research goals. PUBLIC HEALTH RELEVANCE: This award will provide support to mentor young investigators performing patient-oriented GI cancer screening research. It will also provide the candidate to complete studies on this topic. The proposed studies will improve screening techniques for Barrett's esophagus and esophageal adenocarcinoma, facilitate appropriate screening of patients with a family history of colorectal cancer, identify modifiable risk factors for colon adenomas, and identify new tools to detect dysplasia in the gastrointestinal tract.

描述（由申请人提供）：该 K24 职业生涯中期研究员奖将促进培训 GI 研究员参加 GI 流行病学专门培训计划 (T32-DK062708)、指导初级教师申请/完成职业发展奖，以及在 NIH 和 VA 资助的 GI 癌症筛查试验中进行以患者为导向的研究。 “未来成功的最佳预测因素可能是过去的成就。”作为密歇根大学胃肠道流行病学培训项目的首席研究员和主任，我成功指导 100% 的参与者进入学术医学领域。在我们的项目中，GI 研究员完成临床研究设计和统计分析的硕士学位课程，并接受高级研究人员的广泛指导和监督，这有助于他们成功过渡到学术医学。在初级教师完成此培训计划后，我还会为他们提供 K23、R21 和其他职业发展奖项的指导。除了为指导学员和初级教师提供受保护的时间外，这笔赠款还将促进我的研究职业目标：识别胃肠道癌症的风险因素并开发更有效的胃肠道癌症筛查工具。我已成功完成 K23 和 R21 资助，并发表了多篇论文。目前，我是 VA 资助的一项中心资助项目的 PI，该资助项目涉及应用家族史和基因组工具来改善结直肠癌 (CRC) 筛查，并且是一项 U54 资助项目的联合研究员，该项目开发体内生物标志物，用于在内窥镜检查期间识别食道和结肠的发育不良。这些正在进行的研究项目将为学员和初级教师提供一个发展自己的研究的平台。此外，密歇根大学还提供了出色的环境和资源，包括我们的胃肠道流行病学专业培训计划、美国国立卫生研究院资助的密歇根临床研究单位、弗吉尼亚州资助的实践管理和结果研究卓越中心，以及我们公共卫生学院的临床流行病学专业硕士课程。不幸的是，对 GI 研究员和初级教师的指导没有资金支持。目前的 U54 和 VA 资金用于支付研究用品、设备和辅助人员的费用，但提供的资金不足以保护我进行以患者为导向的研究和指导的时间。该 K24 奖项将为实现我的指导和研究目标提供必要的支持。 公共健康相关性：该奖项将为指导年轻研究人员进行以患者为导向的胃肠道癌症筛查研究提供支持。它还将为候选人提供完成该主题的研究的机会。拟议的研究将改进巴雷特食管和食管腺癌的筛查技术，促进对有结直肠癌家族史的患者进行适当筛查，确定结肠腺瘤的可改变危险因素，并确定检测胃肠道发育不良的新工具。