MRI-Guided Cardiac Focused Ultrasound Ablation

MRI 引导心脏聚焦超声消融

• 批准号: 8052730
• 负责人: VIOLA RIEKE
• 金额: $ 9.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8052730
• 关键词: Abdomen; Ablation; Address; Affect; Age; Anatomy; Animal Model; Animals; Area; Arrhythmia; Brain; Breast; Cardiac; Cardiac ablation; Cardiology; Cardiomyopathies; Catheters; Characteristics; Chest; Clinical; Conflict (Psychology); Coupled; Deposition; Development; Electrical Engineering; Elements; Environment; Ethanol; Excision; FDA approved; Faculty; Focused Ultrasound Therapy; Frequencies; Funding; Goals; Grant; Health Care Costs; Heart; Heart Neoplasms; Heating; Hypertrophic Cardiomyopathy; Image; In Vitro; Investigation; Kidney; Left Ventricular Outflow Obstruction; Lesion; Life; Life Expectancy; Liver; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Maps; Measurement; Methods; Modeling; Monitor; Motion; Myocardial; Myocardial tissue; Myocardium; Obstruction; Operative Surgical Procedures; Organ; Patient Care; Patients; Performance; Phase; Physiology; Positioning Attribute; Preclinical Testing; Procedures; Prostate; Protons; Puncture procedure; Radiofrequency Interstitial Ablation; Radiology Specialty; Reproducibility; Research; Resolution; Safety; Secure; Skin; Skin Tissue; Structure; Surgical incisions; Symptoms; System; Tars; Techniques; Technology; Temperature; Testing; Thermal Ablation Therapy; Thermometry; Time; Tissues; Ultrasonic Therapy; Ultrasonic Transducer; Universities; Uterine Fibroids; Work; abstracting; alternative treatment; base; career; design; evaluation/testing; heart motion; heart rhythm; imaging modality; in vivo; innovation; interdisciplinary collaboration; malignant breast neoplasm; new technology; next generation; reconstruction; respiratory; simulation; success; volunteer

Abstract The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non- invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation of the system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MR-guided FUS ablation a noninvasive alternative for the treatment of HOCM. A unique research environment is avail- able to me through interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. This opportunity affords the ability to gain a deep understanding of cardiac physi- ology in addition to further developing my expertise in cardiac magnetic resonance imaging. My career plan includes gaining considerable expertise in the principles of focused ultrasound ablation, including field simulations with finite element models, FUS phantom design, and cardiac MR temperature imaging. My long-term career goal is to secure a tenure-track faculty position so that I can continue to contribute to the field of MR-guided focused ultrasound therapies and to make a fundamental impact on patient care by exploring new, less invasive treatment options.

摘要 该项目的长期目标是开发一种治疗肥厚型梗阻性心肌病的非侵入性治疗方法 (HOCM)。聚焦超声(FUS)是一种很有前途的无创热消融技术。建议的努力 这里介绍了在心脏中使用聚焦超声疗法的主要技术挑战。具体来说，我们的目标是 1)评价磁共振(MR)引导下相控阵聚焦超声(FUS)治疗非小细胞肺癌的疗效。 侵入性消融心肌，包括在射束路径受阻的情况下靶向心脏的策略 胸腔和肺，并使消融与心脏节律同步，2)开发强大的实时靶向和 使用磁共振成像监测心脏温度，以及3)执行初步测试和评估 这个系统。我的直接职业目标是开发必要的融合消融和磁共振成像策略，以使 MR引导下FUS消融是治疗HOCM的一种非侵入性选择。一个独特的研究环境是有益的- 能够通过放射科、心内科和电气系之间的跨学科合作 斯坦福大学工程学专业。这一机会提供了深入了解心脏物理的能力- 除了进一步发展我在心脏磁共振成像方面的专业知识外，我还将继续学习心脏磁共振成像技术。我的职业规划包括 在聚焦超声消融原理方面获得相当多的专业知识，包括有限元的现场模拟 元素模型、FUS体模设计和心脏磁共振温度成像。我的长期职业目标是获得一份 终身教职，这样我就可以继续为磁共振引导的聚焦超声疗法领域做出贡献 并通过探索新的、侵入性更小的治疗方案对患者护理产生根本性影响。