NANOMATERIALS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这个核心将起到三个作用。首先，它将为每个项目开发用于药物输送的纳米材料。这将包括用于药物、蛋白质和核酸输送的新纳米载体，包括过氧化氢酶纳米酶(项目1)和铜锌超氧化物歧化酶纳米酶(项目2)、紫杉醇聚合物胶束(项目3)和siRNA纳米载体(项目4)。 第二，核心将整合纳米技术实验室的资源，对纳米材料进行全面和深入的表征。综合表征技术包括：静态光散射、动态光散射、Zeta电位测量、原子力显微镜、透射电子显微镜和荧光光谱。 第三，该核心将使用各自的细胞系和动物模型来评估所有新合成的纳米材料的安全性，并将为所有研究人员提供受控和标准化的生物用材料。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This core will serve three functions. First, it will develop nanoscale materials for drug delivery for each of projects. This will include new nanocarriers for drug, protein and nucleic acids delivery and include catalase nanozymes (Project 1) and copper-zinc superoxide dismutase nanozymes (Project 2), paclitaxel polymeric micelles (Project 3), and siRNA nanocarriers (Project 4). Second, the core will integrate resources of the nanotechnology laboratories for a comprehensive and in-depth characterization of the nanomaterials. The combined characterization techniques include: static light scattering; dynamic light scattering; zeta-potential measurements; atomic force microscopy; transmission electron microscopy; and fluorescence spectroscopy. Third, the core will evaluate safety of all new synthesized nanomaterials using respective cell lines and animal models, and will provide all investigators with controlled and standardized materials for biological use.