OKHSC COBRE: ADMINISTRATIVE AND MENTORING CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 糖尿病在美国和世界上是一种流行病。俄克拉荷马州是糖尿病患病率最高的州之一。据估计，俄克拉荷马州约有10%的人口患有糖尿病，在我们的一些美洲原住民社区中，这一比例可能高达40%。因此，糖尿病是俄克拉荷马州劳动人口健康的主要威胁，也是社会和经济负担。2005年，俄克拉荷马大学健康科学中心(OUHSC)将糖尿病研究确定为该大学未来五年研究战略计划的两大优先事项之一。俄克拉何马州在2006年批准了1050万美元作为建立哈罗德·哈姆俄克拉荷马糖尿病中心的初始资金。该中心得到了美洲原住民的支持。为了进一步扩大我们目前在俄克拉何马州的糖尿病研究项目，OUHSC建议糖尿病申请COBRE，目标如下：1)指导有前途的初级研究人员(PJI)，并支持他们成为NIH资助的独立研究人员。该项目选择了5名PJI，每个人至少有一名导师。除了OUHSC战略计划，COBRE还将招聘新的初级调查人员，以扩大我们的糖尿病研究计划。2)建立支持糖尿病研究的研究基础设施，形成新兴的哈罗德·哈姆俄克拉荷马州糖尿病中心的核心。3)促进和加强基础科学家和临床医生之间的合作，并促进转化研究，以开发新的糖尿病治疗和预防措施。这5个PJI有不同的项目，从基础长凳研究到干预研究。导师团队包括在糖尿病研究和糖尿病护理方面具有经验的知名科学家和临床医生。4)通过与部落建立伙伴关系，改善美洲原住民糖尿病的研究和干预。一些导师正在进行研究美洲原住民糖尿病的项目。PJI的两个项目将解决美洲原住民的遗传因素和糖尿病干预问题。这个科布雷项目如果得到资助，将大大加强俄克拉何马州的糖尿病研究，并为哈罗德·哈姆俄克拉何马州糖尿病中心奠定核心地位。这项中心拨款将对俄克拉荷马州糖尿病患者的护理和生活质量产生重大影响，特别是在占不成比例的少数族裔人群中 糖尿病的流行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diabetes is an epidemic in the US and in the world. Oklahoma is among the states with highest diabetes prevalence. As estimated, approximately 10% of the population in Oklahoma is diabetic, and among some of our Native Americans communities, the prevalence can be as high as 40%. Thus, diabetes represents a major threat to the health of the working population and a social and economic burden in Oklahoma. In 2005, University of Oklahoma Health Sciences Center (OUHSC) identified diabetes research as one of the top two priorities for the University's Research Strategic Plan for the next five years. The state of Oklahoma approved $10.5 million in 2006 as the initial funds to establish The Harold Hamm Oklahoma Diabetes Center. Native American support for the center has been secured. To further expand our current diabetes research program in Oklahoma, OUHSC recommended diabetes to apply for a COBRE with the following goals: 1) To mentor promising junior investigators (PJI) in diabetes research and support them to become NIH funded independent investigators. This project has selected 5 PJI with at least one mentor each. Together with the OUHSC Strategic Plan, the COBRE will also recruit new junior investigators to expand our diabetes research program. 2) To establish research infrastructures to support diabetes research and form a core for the emerging Harold Hamm Oklahoma Diabetes Center. 3) To foster and enhance collaborations between basic scientists and clinicians, and facilitate translational research toward the development of new treatments and preventive measures for diabetes. The 5 PJI have diverse projects from basic bench research to intervention studies. The mentor team includes established scientists and clinicians with experience in diabetes research and diabetes care. 4) To improve research and intervention for diabetes in Native Americans by forming partnerships with the tribes. Some of mentors have ongoing projects to study diabetes in Native Americans. Two PJI projects will address genetic factors and interventions for diabetes in Native Americans. This COBRE, if funded, will greatly strengthen diabetes research in Oklahoma and establish the core for The Harold Hamm Oklahoma Diabetes Center. This center grant will have great impacts on diabetes care and the quality of life of diabetic patients in Oklahoma, especially among minority populations who bear a disproportionate share of the diabetes epidemic.