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中文摘要
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项目摘要 糖尿病研究被公认为研究战略中的两个战略领域之一 俄克拉荷马州大学健康科学中心(OUHSC)的计划。这个项目的主要目标是 COBRE旨在增加糖尿病研究人员的临界质量,并改善基础设施, OUHSC的糖尿病研究。我们的长期目标是申请NIH P30糖尿病研究 中心(DRC)。在过去九年的COBRE支持中,我们与哈罗德 哈姆糖尿病中心,并达到了我们的里程碑,第一阶段和第二阶段。眼镜蛇已经 孵化了八项NIH R01赠款、两项R21资助和来自研究基金会等的多项赠款 美国糖尿病协会和美国心脏协会。初级 由COBRE支持的研究人员已经发表了207篇同行评审论文。五 由COBRE支持的初级研究员已晋升为副教授。在 此外,COBRE还招募了四名NIH资助的糖尿病研究人员进入OUHSC。的 行政核心在领导COBRE业务方面发挥了核心作用,并为以下方面做出了贡献: 这些成就。第三阶段的主要目标是进一步扩大这些成功 并协助研究中心成为可持续的研究设施, 用户付费和机构资源相结合。在第三阶段,行政核心将 继续对整个COBRE进行集中管理,并协调COBRE的活动 以及COBRE所有组件之间的相互作用。行政核心还将促进 糖尿病COBRE与OUHSC的其他COBRE和研究中心的相互作用, 在整个俄克拉荷马州。该核心将努力改善糖尿病研究 环境和促进糖尿病研究的合作。这一核心将促进资源 和数据共享策略,并确保遵守人类受试者,脊椎动物和 生物安全法规。这一核心将极大地促进COBRE的持续增长, 实现其目标。
英文摘要
PROJECT SUMMARY Diabetes research is recognized as one of the two strategic areas in the Research Strategic Plan of The University of Oklahoma Health Sciences Center (OUHSC). The major goal of this COBRE is to increase the critical mass of diabetes researchers and improve infrastructure for diabetes research at OUHSC. Our long-term goal is to apply for a NIH P30 Diabetes Research Center (DRC). In the past nine years of COBRE support, we have closely worked with the Harold Hamm Diabetes Center and reached our milestones of Phase I and Phase II. The COBRE has incubated eight NIH R01 grants, two R21s and multiple grants from research foundations such as the American Diabetes Association and the American Heart Association. The Junior Investigators supported by the COBRE have published 207 peer-reviewed papers. Five of the Junior Investigators supported by the COBRE have been promoted to Associate Professors. In addition, the COBRE has recruited four NIH-funded diabetic researchers into OUHSC. The Administrative Core has played a central role in leading COBRE operations and contributed to these achievements. The major goal of this Core in Phase III is to further expand these successes and assist the research Cores to become sustainable research facilities supported by a combination of user fees and institutional resources. In Phase III, the Administrative Core will continue to provide central management of the entire COBRE and coordinate COBRE activities and interactions among all of the COBRE components. The Administrative Core will also facilitate interactions of the Diabetes COBRE with other COBREs and research Centers at OUHSC and throughout the State of Oklahoma. This Core will make an effort to improve the diabetes research environment and facilitate collaborations in diabetes research. This Core will promote resource and data sharing strategies and ensure compliance with human subjects, vertebrate animals and biosafety regulations. This Core will greatly facilitate the continuous growth of the COBRE to achieve its goals.
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Dysregulation of PPARα in RPE degeneration
Sustained release of fenofibrate for the treatment of diabetic retinopathy
  • 批准号:
    10521702
  • 项目类别:
  • 资助金额:
    $55.18万
  • 财政年份:
    2022
  • 负责人:
    Jian-Xing Ma
  • 依托单位:
cGAS-STING signaling in diabetic retinopathy
cGAS-STING signaling in diabetic retinopathy
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