Tenth and Eleventh International Symposia on Neurobiology and Neuroendocrinology

描述(申请人提供)：第十届和第十一届神经生物学和神经内分泌衰老国际研讨会将于2010年7月25-30日和2012年7月在奥地利布雷根茨举行。这些会议的目的是聚集一组研究人员，他们最近在衰老机制研究方面取得了重大进展，特别是在中枢神经系统衰老、神经保护和神经退行性疾病的治疗方面。具体主题将包括IGF-1在大脑中的作用，SHC蛋白在内皮功能中的作用，线粒体调节蛋白，以及氧化应激和神经肌肉连接。两个讲座将专门讨论在了解生殖荷尔蒙在衰老中的作用方面的最新进展。关于衰老机制的讲座还将包括从进化蛋白质组适应的角度介绍衰老与抗应激的关系的新数据。与中枢神经系统老化有关的机制的讨论将包括下丘脑激素在痴呆症中的作用，压力诱导的阿尔茨海默病病理迟缓，以及改善阿尔茨海默病患者认知的治疗方法。有关神经保护机制的讲座包括从蠕虫到人类的常见神经退化机制，以及极长寿的神经生物学。我们特意包括了广泛的主题，并召集了一群通常不会参加同一会议的科学家。会议的形式仿照戈登研究会议，鼓励对提交的材料进行正式和非正式的讨论。会议记录将在研讨会后大约六个月内作为实验老年学的特刊发表。强烈鼓励包括研究生和博士后研究员在内的初级调查人员参与，这项提案寻求为那些正在接受培训或担任初级教师职位并计划在海报会议上展示他们的发现的美国参与者提供补贴。我们还在寻求为美国特邀发言者的费用提供部分支持。

DESCRIPTION (provided by applicant): The Tenth and Eleventh International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 25-30, 2010 and in July 2012. The purpose of these meetings is to bring together a group of investigators who made recent significant advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and treatment of neurodegenerative disease. Specific topics will include the roles of IGF-1 in the brain, shc proteins in endothelial function, mitochondrial regulator proteins, and oxidative stress and the neuromuscular junction. Two lectures will specifically address recent advances in understanding the role of reproductive hormones in aging. Lectures dealing with the mechanisms of aging will also include presentation of new data on the relationship of aging to stress resistance from an evolutionary proteomic adaptation perspective. Discussion of mechanisms specifically related to aging of the CNS will include the roles hypothalamic hormones in dementia, stress-induced retardation of Alzheimer's disease pathology and a therapeutic approach to improve cognition in Alzheimer's disease patients. Lectures about neuroprotective mechanisms include neurodegenerative mechanisms common from worm to man and neurobiology in extreme longevity. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. Participation of junior investigators, including graduate students and post-doctoral fellows is strongly encouraged and this proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.