Tenth and Eleventh International Symposia on Neurobiology and Neuroendocrinology

描述（由申请人提供）：第十届和第十一届神经生物学和神经内分泌衰老国际研讨会将于 2010 年 7 月 25-30 日和 2012 年 7 月在奥地利布雷根茨举行。这些会议的目的是汇集一组在衰老机制研究方面取得最新重大进展的研究人员，特别是中枢神经系统衰老、神经保护和神经退行性疾病的治疗。具体主题包括 IGF-1 在大脑中的作用、shc 蛋白在内皮功能中的作用、线粒体调节蛋白以及氧化应激和神经肌肉接头。两场讲座将专门讨论了解生殖激素在衰老中的作用的最新进展。涉及衰老机制的讲座还将包括从进化蛋白质组适应角度介绍衰老与抗压能力关系的新数据。与中枢神经系统衰老相关的机制的讨论将包括下丘脑激素在痴呆中的作用、应激引起的阿尔茨海默病病理学迟缓以及改善阿尔茨海默病患者认知的治疗方法。关于神经保护机制的讲座包括从蠕虫到人类常见的神经退行性机制以及极端长寿的神经生物学。我们特意涵盖了广泛的主题，并聚集了一组通常不会参加同一会议的科学家。会议的形式模仿戈登研究会议，鼓励对所提交的材料进行正式和非正式的讨论。会议记录将在研讨会结束后约六个月内作为实验老年学特刊出版。强烈鼓励包括研究生和博士后研究员在内的初级研究人员的参与，该提案寻求资金为那些正在接受培训或担任初级教职人员并计划在海报会议上展示其发现的美国参与者提供津贴。我们还寻求对来自美国的受邀演讲者的费用提供部分支持。

DESCRIPTION (provided by applicant): The Tenth and Eleventh International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 25-30, 2010 and in July 2012. The purpose of these meetings is to bring together a group of investigators who made recent significant advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and treatment of neurodegenerative disease. Specific topics will include the roles of IGF-1 in the brain, shc proteins in endothelial function, mitochondrial regulator proteins, and oxidative stress and the neuromuscular junction. Two lectures will specifically address recent advances in understanding the role of reproductive hormones in aging. Lectures dealing with the mechanisms of aging will also include presentation of new data on the relationship of aging to stress resistance from an evolutionary proteomic adaptation perspective. Discussion of mechanisms specifically related to aging of the CNS will include the roles hypothalamic hormones in dementia, stress-induced retardation of Alzheimer's disease pathology and a therapeutic approach to improve cognition in Alzheimer's disease patients. Lectures about neuroprotective mechanisms include neurodegenerative mechanisms common from worm to man and neurobiology in extreme longevity. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. Participation of junior investigators, including graduate students and post-doctoral fellows is strongly encouraged and this proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.