Tenth and Eleventh International Symposia on Neurobiology and Neuroendocrinology

描述（由申请人提供）：第十届和第十一届国际神经生物学和神经内分泌学衰老研讨会将于2010年7月25日至30日在奥地利布雷根茨举行，并于2012年7月举行。这些会议的目的是汇集一组最近在衰老机制研究方面取得重大进展的研究人员，特别强调CNS衰老，神经保护和神经退行性疾病的治疗。具体的主题将包括IGF-1在大脑中的作用，shc蛋白在内皮功能，线粒体调节蛋白，氧化应激和神经肌肉接头。两个讲座将专门讨论最近的进展，了解生殖激素在衰老中的作用。处理衰老机制的讲座也将包括从进化蛋白质组学适应的角度介绍衰老与抗应激能力关系的新数据。与中枢神经系统衰老相关的机制的讨论将包括下丘脑激素在痴呆中的作用，阿尔茨海默病病理学的应激诱导的阻滞和改善阿尔茨海默病患者认知的治疗方法。关于神经保护机制的讲座包括从蠕虫到人类的神经退行性机制和极端长寿的神经生物学。我们故意包括广泛的主题，并聚集了一群通常不会参加同一次会议的科学家。会议的形式是仿照戈登研究会议，并鼓励正式和非正式的讨论所提出的材料。会议记录将在研讨会后大约六个月内作为《实验老年学》特刊出版。强烈鼓励初级研究人员，包括研究生和博士后研究员的参与，该提案寻求资金，为正在接受培训或担任初级教师职位并计划在海报会议上展示其研究结果的美国参与者提供津贴。我们还在寻求对应邀从美国来的发言者的费用提供部分支助。

DESCRIPTION (provided by applicant): The Tenth and Eleventh International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 25-30, 2010 and in July 2012. The purpose of these meetings is to bring together a group of investigators who made recent significant advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and treatment of neurodegenerative disease. Specific topics will include the roles of IGF-1 in the brain, shc proteins in endothelial function, mitochondrial regulator proteins, and oxidative stress and the neuromuscular junction. Two lectures will specifically address recent advances in understanding the role of reproductive hormones in aging. Lectures dealing with the mechanisms of aging will also include presentation of new data on the relationship of aging to stress resistance from an evolutionary proteomic adaptation perspective. Discussion of mechanisms specifically related to aging of the CNS will include the roles hypothalamic hormones in dementia, stress-induced retardation of Alzheimer's disease pathology and a therapeutic approach to improve cognition in Alzheimer's disease patients. Lectures about neuroprotective mechanisms include neurodegenerative mechanisms common from worm to man and neurobiology in extreme longevity. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. Participation of junior investigators, including graduate students and post-doctoral fellows is strongly encouraged and this proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.