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Fourteenth & Fifteenth International Symposia on Neurobiology & Neuroendocrinology of Aging

第十四

基本信息

批准号：
9899821
负责人：
HOLLY M. BROWN-BORG
金额：
$ 4.05万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9899821
关键词：
Address Age Aging Alzheimer&apos s Disease Area Austria Biology of Aging Caloric Restriction Cell Aging Clinical Collaborations Communication Dietary Intervention Disease Endocrine system Endocrinology Environment Epigenetic Process Faculty Funding Genomic Instability Geriatrics Gerontology Health Hormonal Human Huntington Disease Impaired cognition Inflammation International Investigation Left Link Mediator of activation protein Metabolic dysfunction Mitochondria Modeling Molecular Biology Neuraxis Neurobiology Neurodegenerative Disorders Neuroendocrinology Neurons Oral Oxidation-Reduction Parkinson Disease Participant Population Positioning Attribute Postdoctoral Fellow Publishing Regenerative research Rejuvenation Request for Applications Request for Proposals Research Research Personnel Schedule Science Scientist Senior Scientist Series Sirolimus Slide Technology Time Tissues Training Translations United States age related age related neurodegeneration aged detection of nutrient exhaustion graduate student hormone deficiency interest lectures meetings mitochondrial dysfunction neuroprotection novel posters proteostasis stem cells student conference symposium

项目摘要

Project Summary The Fourteenth and Fifteenth International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 15-20, 2018 and in July 2020. The purpose of these meetings is to bring together a group of investigators who made recent advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and neurodegenerative disease. Moreover, the endocrine system and metabolic dysfunction tie many additional aging research areas together (genomic instability, mitochondrial dysfunction, cellular senescence, epigenetic changes, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, inflammation). We are directly addressing several of these topics in this Symposium, many in the context of neurobiology and endocrinology. Prominent among the scheduled lectures are the continued search for mechanisms of age-related disease, increasing appreciation of concomitant involvement of multiple interacting mechanisms, and attempts to evaluate their relative importance. Recent studies significantly increased appreciation of mediators of potential aging retardation, calorie restriction, hormone deficiency and rapamycin. Similarly, modulation of health and disease by translational dietary intervention will be addressed. As the field continues to search for and study regenerative mechanisms, talks devoted to reprogramming of aged tissue and rejuvenation are included. Several lectures will integrate information in neurobiology with aging, redox state, plasticity, and mitochondrial dynamics. Progressive changes in the age profile of human populations underlies enormous significance of age related neurodegenerative disease and cognitive impairment. The latest breakthroughs in our understanding of Alzheimer's, Parkinson's and Huntington's disease will be covered in multiple lectures, further strengthening this link. Each of these topics will be covered by investigators that recently made major advances in the corresponding areas of investigation. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. We have always strongly encouraged the participation of junior investigators, including graduate students and postdoctoral fellows. This proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.

项目总结