Fourteenth & Fifteenth International Symposia on Neurobiology & Neuroendocrinology of Aging

项目摘要 第十四届和第十五届神经生物学和神经内分泌学国际研讨会 老龄将于2018年7月15日至20日和2020年7月在奥地利布雷根茨举行。这些活动的目的是 会议的目的是让一群在 衰老的机制，特别强调中枢神经系统的衰老、神经保护和 神经退行性疾病。此外，内分泌系统和代谢障碍将许多 其他衰老研究领域(基因组不稳定、线粒体功能障碍、 细胞衰老、表观遗传学变化、蛋白平衡丧失、去调控的营养感知、茎 细胞衰竭、炎症)。在这篇文章中，我们直接讨论了其中几个主题 研讨会，许多是在神经生物学和内分泌学的背景下举行的。突出的是 预定的讲座是继续探索年龄相关疾病的机制，越来越多 认识到同时涉及多种互动机制，并试图 评估它们的相对重要性。最近的研究显著增加了对 潜在衰老延缓、卡路里限制、激素缺乏和雷帕霉素的介体。 同样，通过转化性饮食干预来调节健康和疾病将是 地址。随着该领域继续寻找和研究再生机制，谈话 致力于老化组织的重新编程和返老还童。将有几场讲座 将神经生物学中的信息与衰老、氧化还原状态、可塑性和线粒体结合起来 动力学。人类人口年龄结构的逐步变化是巨大的基础 年龄相关性神经退行性疾病和认知功能障碍的意义。最新的 我们对阿尔茨海默氏症、帕金森氏症和亨廷顿氏病的理解的突破将 将在多个讲座中涵盖，进一步加强了这一联系。这些主题中的每个都将是 由最近在相应领域取得重大进展的调查人员覆盖 调查。我们特意包括了广泛的主题，并召集了一组科学家 通常不会参加同一会议的人。会议的形式是仿照的 戈登研究会议并鼓励对材料进行正式和非正式的讨论 呈上了。会议记录将作为实验老年学的特刊发表在 在研讨会之后大约六个月。我们一直强烈鼓励 初级调查人员的参与，包括研究生和博士后研究员。这 一项提案寻求为正在接受培训或正在接受培训的美国参与者提供津贴的资金 在初级教员职位上，并计划在海报会议上展示他们的发现。 我们还在寻求为美国特邀发言者的费用提供部分支持。

Project Summary The Fourteenth and Fifteenth International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 15-20, 2018 and in July 2020. The purpose of these meetings is to bring together a group of investigators who made recent advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and neurodegenerative disease. Moreover, the endocrine system and metabolic dysfunction tie many additional aging research areas together (genomic instability, mitochondrial dysfunction, cellular senescence, epigenetic changes, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, inflammation). We are directly addressing several of these topics in this Symposium, many in the context of neurobiology and endocrinology. Prominent among the scheduled lectures are the continued search for mechanisms of age-related disease, increasing appreciation of concomitant involvement of multiple interacting mechanisms, and attempts to evaluate their relative importance. Recent studies significantly increased appreciation of mediators of potential aging retardation, calorie restriction, hormone deficiency and rapamycin. Similarly, modulation of health and disease by translational dietary intervention will be addressed. As the field continues to search for and study regenerative mechanisms, talks devoted to reprogramming of aged tissue and rejuvenation are included. Several lectures will integrate information in neurobiology with aging, redox state, plasticity, and mitochondrial dynamics. Progressive changes in the age profile of human populations underlies enormous significance of age related neurodegenerative disease and cognitive impairment. The latest breakthroughs in our understanding of Alzheimer's, Parkinson's and Huntington's disease will be covered in multiple lectures, further strengthening this link. Each of these topics will be covered by investigators that recently made major advances in the corresponding areas of investigation. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. We have always strongly encouraged the participation of junior investigators, including graduate students and postdoctoral fellows. This proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.