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Fourteenth & Fifteenth International Symposia on Neurobiology & Neuroendocrinology of Aging

第十四

基本信息

批准号：
9899821
负责人：
HOLLY M. BROWN-BORG
金额：
$ 4.05万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9899821
关键词：
Address Age Aging Alzheimer&apos s Disease Area Austria Biology of Aging Caloric Restriction Cell Aging Clinical Collaborations Communication Dietary Intervention Disease Endocrine system Endocrinology Environment Epigenetic Process Faculty Funding Genomic Instability Geriatrics Gerontology Health Hormonal Human Huntington Disease Impaired cognition Inflammation International Investigation Left Link Mediator of activation protein Metabolic dysfunction Mitochondria Modeling Molecular Biology Neuraxis Neurobiology Neurodegenerative Disorders Neuroendocrinology Neurons Oral Oxidation-Reduction Parkinson Disease Participant Population Positioning Attribute Postdoctoral Fellow Publishing Regenerative research Rejuvenation Request for Applications Request for Proposals Research Research Personnel Schedule Science Scientist Senior Scientist Series Sirolimus Slide Technology Time Tissues Training Translations United States age related age related neurodegeneration aged detection of nutrient exhaustion graduate student hormone deficiency interest lectures meetings mitochondrial dysfunction neuroprotection novel posters proteostasis stem cells student conference symposium

项目摘要

Project Summary The Fourteenth and Fifteenth International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 15-20, 2018 and in July 2020. The purpose of these meetings is to bring together a group of investigators who made recent advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and neurodegenerative disease. Moreover, the endocrine system and metabolic dysfunction tie many additional aging research areas together (genomic instability, mitochondrial dysfunction, cellular senescence, epigenetic changes, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, inflammation). We are directly addressing several of these topics in this Symposium, many in the context of neurobiology and endocrinology. Prominent among the scheduled lectures are the continued search for mechanisms of age-related disease, increasing appreciation of concomitant involvement of multiple interacting mechanisms, and attempts to evaluate their relative importance. Recent studies significantly increased appreciation of mediators of potential aging retardation, calorie restriction, hormone deficiency and rapamycin. Similarly, modulation of health and disease by translational dietary intervention will be addressed. As the field continues to search for and study regenerative mechanisms, talks devoted to reprogramming of aged tissue and rejuvenation are included. Several lectures will integrate information in neurobiology with aging, redox state, plasticity, and mitochondrial dynamics. Progressive changes in the age profile of human populations underlies enormous significance of age related neurodegenerative disease and cognitive impairment. The latest breakthroughs in our understanding of Alzheimer's, Parkinson's and Huntington's disease will be covered in multiple lectures, further strengthening this link. Each of these topics will be covered by investigators that recently made major advances in the corresponding areas of investigation. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. We have always strongly encouraged the participation of junior investigators, including graduate students and postdoctoral fellows. This proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.

项目概要第十四届和第十五届神经生物学与神经内分泌学国际研讨会老龄化将于2018年7月15日至20日和2020年7月在奥地利布雷根茨举行。这些目的会议的目的是将在研究中取得最新进展的一组研究人员聚集在一起衰老机制，特别强调中枢神经系统衰老、神经保护和神经退行性疾病。此外，内分泌系统和代谢功能障碍也与许多因素密切相关。其他衰老研究领域（基因组不稳定性、线粒体功能障碍、细胞衰老、表观遗传变化、蛋白质稳态丧失、营养感应失调、干细胞细胞耗竭、炎症）。我们将在本文中直接讨论其中的几个主题研讨会，许多是关于神经生物学和内分泌学的。其中突出的预定的讲座是不断寻找与年龄相关的疾病的机制，增加认识到多种相互作用机制的同时参与，并尝试评估它们的相对重要性。最近的研究显着提高了对潜在的衰老延迟、热量限制、激素缺乏和雷帕霉素的介质。同样，通过转化饮食干预来调节健康和疾病将是已解决。随着该领域继续寻找和研究再生机制，会谈致力于衰老组织的重新编程和复兴也包括在内。几场讲座将将神经生物学信息与衰老、氧化还原状态、可塑性和线粒体整合起来动力学。人口年龄结构的逐步变化是巨大变化的基础年龄相关的神经退行性疾病和认知障碍的重要性。最新的我们对阿尔茨海默病、帕金森病和亨廷顿病的理解将取得突破多个讲座中都有涉及，进一步加强了这种联系。这些主题中的每一个都将最近在相应领域取得重大进展的研究人员所涵盖调查。我们特意涵盖广泛的主题并聚集了一群科学家通常可能不会参加同一会议。会议的形式模仿戈登研究会议并鼓励对材料进行正式和非正式讨论提出。论文集将作为实验老年学特刊出版研讨会结束后大约六个月。我们一直强烈鼓励初级研究人员的参与，包括研究生和博士后研究员。这该提案寻求资金为正在接受培训或正在接受培训的美国参与者提供津贴担任初级教职人员并计划在海报会议上展示他们的发现。我们还寻求对来自美国的受邀演讲者的费用提供部分支持。