Acute HIV-1 Infections Network Core

急性 HIV-1 感染网络核心

• 批准号: 8105382
• 负责人: John Andrew Crump
• 金额: $ 566.21万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105382
• 关键词: Acute; Animal Experiments; Botswana; Clinical; England; Event; Funding; Gambia; HIV Infections; HIV-1; Immune response; Immunologics; Infection; Knowledge; Malawi; Pathogenesis; Patients; Prevention; Procedures; Process; Research Personnel; Sampling; Series; Sexual Partners; Site; South Africa; Staging; Study Subject; Tanzania; Techniques; Translational Research; Transportation; Uganda; Vaccines; Zambia; transmission process

Prevention of HIV-1 infection requires a more detailed knowledge of HIV-1 transmission than is currently available. Tremendous progress on understanding the pathogenesis of HIV-1 has been made through animal experiments and by clinical translational research. But the most critical information can only be obtained through intensive study of subjects with newly acquired (acute) HIV-1, and if at all possible, the study of "transmission pairs". Unfortunately, it has proven remarkably difficult to identify and study such subjects. First, most investigators have been unable to find a credible number of subjects before a nascent or fully expressed immune response has developed. As a consequence, many investigators wishing to document virologic and immunologic events associated with HIV-1 transmission are forced to study "early" or "recently" infected patients after seroconversion, and often lump these subjects together with acute HIV-1 infections in their analyses. We and others have tried to introduce more precision to the definitions of the first stages of HIV-1 infection, and to develop techniques to study subjects and their sexual partners as soon as possible after HIV-1 transmission before seroconversion. Thus, four specific aims are proposed in this study: Aim 1. To establish the CHAVI Acute HIV-1 Infection (AMI) Network comprised of sites in the US, England, South Africa, Malawi, Tanzania, Uganda, Gambia, Botswana, and Zambia, Aim 2. To establish standard operating procedures for identifying patients with acute HIV infection, transmission pairs, and patients that are HIV-1 exposed and uninfected, Aim 3. To establish standard operating procedures for sample acquisition, sample processing, sample transportation, and sample storage, and Aim 4. To transition select Acute HIV-1 Infection (AHI) Network sites from AHI sites to vaccine trial sites over the 7 year CHAVI funding period. Thus, through the establishment of the CHAVI AHI network, Core B will provide the patient samples to CHAVI investigators for a series of critical studies on truly HIV-1 acutely infected patients.

预防HIV-1感染需要对HIV-1传播有比目前更详细的了解。通过动物实验和临床转化研究，在理解HIV-1的发病机制方面取得了巨大进展。但是，最关键的信息只能通过对新获得的（急性）HIV-1受试者的深入研究，如果可能的话，对“传播对”的研究才能获得。不幸的是，它已被证明是非常困难的识别和研究这些主题。首先，大多数研究人员无法在新生或完全表达的免疫应答形成之前找到可信数量的受试者。因此，许多希望记录与HIV-1传播相关的病毒学和免疫学事件的研究人员被迫“早期”研究。 或血清转换后的“最近”感染患者，并且在他们的分析中经常将这些受试者与急性HIV-1感染混为一谈。我们和其他人试图更精确地定义HIV-1感染的第一阶段，并开发技术，在HIV-1传播后血清转化之前尽快研究受试者及其性伴侣。因此，本研究提出了四个具体目标：目标1。建立CHAVI急性HIV-1感染（AMI）网络，由美国、英国、南非、马拉维、坦桑尼亚、乌干达、冈比亚、博茨瓦纳和赞比亚的站点组成，目标2。为确定急性HIV感染患者、传播对以及HIV-1暴露和未感染患者建立标准操作程序，目标3。建立样本采集、样本处理、样本运输和样本储存的标准操作规程和目标4。将选定的急性HIV-1感染（AHI）网络研究中心从AHI研究中心转变为疫苗试验研究中心 在7年的CHAVI资助期内。因此，通过建立CHAVI AHI网络，核心B将向CHAVI研究人员提供患者样本，用于对真正的HIV-1急性感染患者进行一系列关键研究。