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中文摘要
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描述(由申请人提供):医学的马约诊所学院(MCCOM)倡议最大限度地提高学生多样性(IMSD)的目标是准备代表性不足的少数民族(URM)博士前学生成为未来的国家领导人在疾病相关的基础和转化研究。大多数URM学生的研究培训计划主要集中在基础科学研究。虽然至关重要,但这一重点并不能充分满足URM研究人员了解基础科学研究如何转化为改善健康的需要。这一视角是MCCOM的独特属性。自1997年以来,MCCOM IMSD成功地结合了1)URM博士前学生的补充培训; 2)夏季URM医学生的培训; 3)通过临床研究培训计划(CRTP)对URM医学生进行为期一年或两年的培训。这些MCCOM IMSD活动已完全纳入MCCOM学士后研究教育方案(PREP)由NIGMS资助。这里提出的MCCOM IMSD计划现在将专注于提高URM学生在马约博士学位的经验。M.D.博士程序. IMSD和PREP资助的项目之间的协同作用将仍然是一个主要的优势。在过去的11年中,87%由MCCOM IMSD支持的URM博士预科生已经完成了博士学位或正在努力完成博士学位。MCCOM IMSD还提高了马约教师的技能,以满足URM学生的独特需求。拟议的MCCOM IMSD支持的下一个时期对于继续这个始于1997年的非常成功的项目至关重要,使马约诊所在满足URM受训人员的需求方面保持全国领先地位。具体目标如下:1.支持MCCOM URM博士和医学博士。/博士学生通过提供2年的奖学金支持和专业发展技能在博士学位的开始。训练2.让参与的学生参加严格的口头陈述和写作研讨会,以提高沟通技巧。3.在MCCOM IMSD计划中提供持续的咨询,并定期进行后续进度审查。4.在获得有竞争力的博士后奖学金职位的过程中为博士前URM学生提供咨询。5.通过外部专家评审员和内部咨询委员会评估MCCOM IMSD。 公共卫生相关性:该研究教育计划将在博士学位开始时提供2年的奖学金支持和专业技能发展。训练我们的目标是帮助来自不同背景的学生(例如少数民族/种族,残疾人和来自弱势背景的个人)在博士水平上成功地推进生物医学研究事业,从而促进生物医学研究队伍的多样化。
英文摘要
DESCRIPTION (provided by applicant): The goal of the Mayo Clinic College of Medicine (MCCOM) Initiative for Maximizing Student Diversity (IMSD) is to prepare underrepresented minority (URM) pre-doctoral students to become future national leaders in disease-related basic and translational research. Most URM student research training programs focus primarily on basic science research. Although critically important, this focus does not adequately address the need for URM investigators to appreciate how basic science research translates to improved health. This perspective is a unique attribute of MCCOM. Since 1997 the MCCOM IMSD has successfully combined 1) supplemental training of URM pre-doctoral students; 2) training of summer URM medical students; and 3) training of URM medical students for one or two years through the Clinical Research Training Program (CRTP). These MCCOM IMSD activities have been fully integrated with the MCCOM Post-baccalaureate Research Education Program (PREP) funded by NIGMS. The MCCOM IMSD program proposed here will now focus exclusively on enhancing the experience of URM students in the Mayo Ph.D. and M.D./Ph.D. programs. Synergy between the IMSD and PREP funded programs will remain a major strength. Over the past eleven years 87% of URM pre-doctoral students supported by the MCCOM IMSD have completed their doctoral degree or are on track to do so. The MCCOM IMSD has also improved the skills of Mayo faculty in addressing the unique needs of URM students. The next period of proposed MCCOM IMSD support is critical to continue this highly successful project that began in 1997, maintaining Mayo Clinic as a national leader in addressing the needs of URM trainees. The following specific aims will be accomplished: 1. Support MCCOM URM Ph.D. and M.D. /Ph.D. students by providing 2 years of fellowship support and professional development skills at the outset of Ph.D. training. 2. Engage participating students in rigorous oral presentation and grant writing workshops to improve communication skills. 3. Provide continuous counseling within the MCCOM IMSD program and periodic subsequent progress reviews. 4. Counsel pre-doctoral URM students in the process of obtaining competitive post-doctoral fellowship positions. 5. Evaluate the MCCOM IMSD through an expert external reviewer and internal advisory committee. Public health relevance: This research education program will provide 2 years of fellowship support and professional skills development at the outset of Ph.D. training. The goal is to help students from diverse backgrounds (e.g. ethnic/racial minorities, individuals with disabilities, and individuals from disadvantaged backgrounds) to advance to successful biomedical research careers at the PhD level thus contributing to the diversification of the biomedical research workforce.
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In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastoma
  • 批准号:
    10721036
  • 项目类别:
  • 资助金额:
    $41.47万
  • 财政年份:
    2023
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Genome-wide synthetic lethal screening for vulnerabilities in a cell model of succinate dehydrogenase-loss paraganglioma
  • 批准号:
    10572019
  • 项目类别:
  • 资助金额:
    $22.3万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Fundamental and applied studies of nucleic acids
  • 批准号:
    10323099
  • 项目类别:
  • 资助金额:
    $29.94万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Fundamental and applied studies of nucleic acids
  • 批准号:
    10557080
  • 项目类别:
  • 资助金额:
    $39.75万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
海外基金