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中文摘要
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描述(由申请人提供):梅奥临床医学院(MCCOM)最大化学生多样性倡议(IMSD)的目标是培养未被充分代表的少数民族(URM)博士前学生,使其成为与疾病相关的基础和翻译研究的未来国家领导者。大多数URM学生研究培训项目主要集中在基础科学研究上。尽管至关重要,但这一重点并没有充分解决URM调查人员理解基础科学研究如何转化为改善健康的需要。这种视角是MCCOM的独特属性。自1997年以来,MCCOM IMSD成功地结合了1)对URM博士前学生的补充培训;2)夏季URM医学生的培训;以及3)通过临床研究培训计划(CRTP)对URM医学生进行为期一到两年的培训。MCCOM IMSD的这些活动已经完全融入了由NIGMS资助的MCCOM学士学位后研究教育计划(PREP)。这里建议的MCCOM IMSD项目现在将专门专注于增强URM学生在梅奥博士和医学博士/博士项目中的体验。IMSD和PREP资助的项目之间的协同作用仍将是一个主要优势。在过去的11年里,由MCCOM IMSD资助的URM博士后研究生中,87%已经完成或即将完成博士学位。MCCOM IMSD还提高了Mayo教员的技能,满足了URM学生的独特需求。下一阶段的拟议中的MCCOM IMSD支持对于继续这一始于1997年的非常成功的项目至关重要,该项目保持了梅奥诊所在满足URM实习生需求方面的全国领先地位。将实现以下具体目标:1.在博士培训开始时,通过提供两年的奖学金支持和专业发展技能,支持MCCOM URM博士和医学博士/博士学生。2.让参与的学生参加严谨的口头陈述和赠款写作研讨会,以提高沟通技能。3.在MCCOM国际管理和可持续发展方案内提供持续咨询,并定期进行后续进展审查。4.在获得有竞争力的博士后研究员职位的过程中为博士后研究生提供咨询。5.通过专家外部审查员和内部咨询委员会对MCCOM IMSD进行评价。 公共卫生相关性:这项研究教育计划将在博士培训开始时提供两年的奖学金支持和专业技能发展。目标是帮助来自不同背景的学生(例如少数族裔、残疾人和弱势背景的个人)在博士水平上取得成功的生物医学研究职业,从而促进生物医学研究劳动力的多样化。
英文摘要
DESCRIPTION (provided by applicant): The goal of the Mayo Clinic College of Medicine (MCCOM) Initiative for Maximizing Student Diversity (IMSD) is to prepare underrepresented minority (URM) pre-doctoral students to become future national leaders in disease-related basic and translational research. Most URM student research training programs focus primarily on basic science research. Although critically important, this focus does not adequately address the need for URM investigators to appreciate how basic science research translates to improved health. This perspective is a unique attribute of MCCOM. Since 1997 the MCCOM IMSD has successfully combined 1) supplemental training of URM pre-doctoral students; 2) training of summer URM medical students; and 3) training of URM medical students for one or two years through the Clinical Research Training Program (CRTP). These MCCOM IMSD activities have been fully integrated with the MCCOM Post-baccalaureate Research Education Program (PREP) funded by NIGMS. The MCCOM IMSD program proposed here will now focus exclusively on enhancing the experience of URM students in the Mayo Ph.D. and M.D./Ph.D. programs. Synergy between the IMSD and PREP funded programs will remain a major strength. Over the past eleven years 87% of URM pre-doctoral students supported by the MCCOM IMSD have completed their doctoral degree or are on track to do so. The MCCOM IMSD has also improved the skills of Mayo faculty in addressing the unique needs of URM students. The next period of proposed MCCOM IMSD support is critical to continue this highly successful project that began in 1997, maintaining Mayo Clinic as a national leader in addressing the needs of URM trainees. The following specific aims will be accomplished: 1. Support MCCOM URM Ph.D. and M.D. /Ph.D. students by providing 2 years of fellowship support and professional development skills at the outset of Ph.D. training. 2. Engage participating students in rigorous oral presentation and grant writing workshops to improve communication skills. 3. Provide continuous counseling within the MCCOM IMSD program and periodic subsequent progress reviews. 4. Counsel pre-doctoral URM students in the process of obtaining competitive post-doctoral fellowship positions. 5. Evaluate the MCCOM IMSD through an expert external reviewer and internal advisory committee. Public health relevance: This research education program will provide 2 years of fellowship support and professional skills development at the outset of Ph.D. training. The goal is to help students from diverse backgrounds (e.g. ethnic/racial minorities, individuals with disabilities, and individuals from disadvantaged backgrounds) to advance to successful biomedical research careers at the PhD level thus contributing to the diversification of the biomedical research workforce.
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In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastoma
  • 批准号:
    10721036
  • 项目类别:
  • 资助金额:
    $41.47万
  • 财政年份:
    2023
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Genome-wide synthetic lethal screening for vulnerabilities in a cell model of succinate dehydrogenase-loss paraganglioma
  • 批准号:
    10572019
  • 项目类别:
  • 资助金额:
    $22.3万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Fundamental and applied studies of nucleic acids
  • 批准号:
    10323099
  • 项目类别:
  • 资助金额:
    $29.94万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
Fundamental and applied studies of nucleic acids
  • 批准号:
    10557080
  • 项目类别:
  • 资助金额:
    $39.75万
  • 财政年份:
    2022
  • 负责人:
    LOUIS JAMES MAHER
  • 依托单位:
海外基金