Post-baccalaureate Training in Biomedical Research

描述（由申请人提供）：大多数针对代表性不足群体的个人的研究培训计划只关注基础科学研究。尽管这些项目至关重要，但往往未能在基础科学研究和改善健康之间提供激励性联系。马约学士后研究教育计划（PREP）的目标是增加选择生物医学研究职业，特别是疾病导向研究的代表性不足的群体的人数。该计划既帮助那些可能成功的人，也帮助那些PREP经验可能在他们的职业道路上真正起关键作用的人。我们的假设是，来自代表性不足群体的学生越来越多地选择疾病导向的基础或转化研究职业，当他们清楚地看到这项研究在改善人类健康方面的价值。马约的PREP是成功和成熟的，自1996年马约在全国范围内开创这一计划以来，它一直是机构教育多样性努力的独特基石。马约对多样性的持续承诺得到了最高管理层的支持，并导致了该机构的重大积极变化。马约独特的、高度整合的临床和生物医学研究项目为培养学徒科学家的职业目标提供了理想的环境。马约的博士研究生院，医学院，MSTP培训网站和住院医师计划是著名的马约诊所三级护理中心的一部分。马约PREP的持续资助积极影响整个马约校园的多样性。PREP与其他正在进行的马约多样性计划协同作用，包括马约的NIH IMSD博士前计划，URM夏季研究计划，以及其他机构支持的多样性教育计划，通过马约新成立的多样性教育办公室指导。马约成功的PREP和IMSD计划庆祝URM学生在暑期本科，临床研究，PREP，博士和MD/博士研究范围之间的同行指导和相互支持。这种协同作用对于学生的自我效能感，生物医学研究科学家的身份以及培训路径的阐明至关重要。PREP在之前的资助周期中取得的进展，以及来自13个队列的PREP学生的纵向数据，提供了成功促进研究生培训的客观证据，以获得博士学位。在下一个资金周期，我们将保持我们成功的计划，同时增加计划评估，导师培训和招聘。具体目标：1.每年招募马约9名新的学士后学徒科学家（4年内总共多达36名）进行研究计划，并对个性化的学生学术和专业发展进行密集的充实。PREP学徒科学家可能会接受一年或两年的培训，这取决于他们的需要。2.保持马约的PREP计划，其中> 75%的学士后学徒科学家进入博士或MD/博士课程，主要兴趣是基于实验室或转化研究。3.丰富马约的学士后学徒科学家的技能，成功启动和完成博士学位的重要。马约PREP计划的每个方面都旨在提高学生的创造力，自我效能，承诺和科学家的目的。该计划提供专门设计的活动，以鼓励学生对与健康差距相关的研究领域的兴趣。4.通过研究生院及以后，改善马约学士后学徒科学家的长期联系和持续指导。我们将与马约的NIH资助的少数民族博士预科生IMSD计划和马约的多样性教育办公室协同实现这一目标。5.通过半结构化访谈继续进行内部和外部评估，确保马约PREP活动的实用性、可行性、适当性和准确性。

DESCRIPTION (provided by applicant): The majority of research training programs for individuals from underrepresented groups focus only on basic science research. Although critically important, these programs often fail to provide the motivational link between basic science research and improved health. The goal of the Mayo Post-Baccalaureate Research Education Program (PREP) is to increase the number of individuals from underrepresented groups who choose biomedical research careers, especially disease-oriented research. The program assists both those likely to succeed and those for whom the PREP experience may truly be pivotal in their career paths. Our hypothesis is that students from underrepresented groups increasingly choose disease-directed basic or translational research careers when they clearly see the value of this research in improving human health. Mayo's PREP is successful and mature, having been a unique cornerstone of institutional education diversity efforts since Mayo pioneered this program nationally in 1996. Mayo's ongoing commitment to diversity is supported from the highest executive level and has resulted in significant positive changes at the institution. The unique, highly-integrated clinical and biomedical research programs at Mayo provide an ideal environment to foster the career goals of apprentice scientists. Mayo's PhD graduate school, medical school, MSTP training site, and residency program are parts of the famed Mayo Clinic tertiary care center. Sustained funding of the Mayo PREP positively impacts diversity across the Mayo campus. The PREP synergizes with other ongoing Mayo diversity programs, including Mayo's NIH IMSD pre-doctoral program, URM summer research programs, and other institutionally-supported diversity education initiatives directed through Mayo's newly-formed Education Office for Diversity. Mayo's successful PREP and IMSD programs celebrate peer mentoring and mutual support between URM students across the summer undergraduate, clinical research, PREP, PhD, and MD/PhD research spectrum. This synergy is critical for student self-efficacy, identity as biomedical research scientists, and elucidation of the training path. PREP progress during the prior funding cycle, together with longitudinal data derived from 13 cohorts of prior PREP students, provides objective evidence of success in promoting graduate training leading to the PhD degree. During the next funding cycle we will maintain our successful program while increasing program evaluation, mentor training, and recruitment. Specific aims: 1. Recruit to Mayo 9 new post-baccalaureate apprentice scientists each year (total of up to 36 over 4 years) for a program of research with intensive enrichment toward individualized student academic and professional development. PREP apprentice scientists may receive one or two years of training, depending on their needs. 2. Maintain Mayo's PREP program where > 75% of post-baccalaureate apprentice scientists enter PhD or MD/PhD programs with a primary interest in laboratory-based or translational research. 3. Enrich Mayo's post-baccalaureate apprentice scientists with skills important for successful initiation and completion of the PhD degree. Each aspect of the Mayo PREP program is designed to enhance students' creativity, self-efficacy, commitment, and purpose as scientists. The program offers activities specifically designed to encourage student interest in research areas related to health disparities. 4. Improve long-term contact and ongoing mentoring of Mayo post-baccalaureate apprentice scientists through graduate school and beyond. We will achieve this goal in synergy with Mayo's NIH-funded IMSD program for minority pre-doctoral students, and with Mayo's Education Office for Diversity. 5. Continue internal and external evaluation with semi-structured interviews ensuring increased utility, feasibility, propriety, and accuracy of Mayo's PREP activities.