Post-baccalaureate Training in Biomedical Research

描述(由申请者提供)：大多数针对代表性不足群体的个人的研究培训计划只专注于基础科学研究。尽管这些项目至关重要，但它们往往不能提供基础科学研究和改善健康之间的激励联系。梅奥毕业后研究教育计划(PREP)的目标是增加来自代表性不足群体中选择生物医学研究职业的个人数量，特别是以疾病为导向的研究。该计划既帮助那些有可能成功的人，也帮助那些对他们的职业生涯可能真正起到关键作用的人。我们的假设是，来自代表性不足群体的学生，当他们清楚地看到这项研究在改善人类健康方面的价值时，他们越来越多地选择以疾病为导向的基础研究或转化性研究职业。梅奥的准备工作是成功和成熟的，自1996年梅奥在全国率先推出这一计划以来，它一直是院校教育多样化努力的独特基石。梅奥对多样性的持续承诺得到了最高管理层的支持，并已导致该机构发生了重大的积极变化。梅奥独特的、高度整合的临床和生物医学研究项目为培养见习科学家的职业目标提供了理想的环境。梅奥的博士研究生学校、医学院、MSTP培训站点和住院医师计划都是著名的梅奥诊所第三级护理中心的一部分。梅奥筹备工作的持续资金对整个梅奥校园的多样性产生了积极影响。该预备课程与梅奥正在进行的其他多样性项目相配合，包括梅奥的NIH IMSD博士前项目、URM暑期研究项目，以及通过梅奥新成立的多样性教育办公室指导的其他机构支持的多样性教育倡议。梅奥成功的预科项目和IMSD项目庆祝URM学生在暑期本科生、临床研究、预科、博士和医学/博士研究领域的同行指导和相互支持。这种协同作用对于学生的自我效能感、作为生物医学研究科学家的身份认同以及对培训路径的阐明至关重要。前一个资助周期的预科进展，加上来自13个预科学生队列的纵向数据，提供了客观证据，证明成功地促进了研究生培训，从而获得博士学位。在下一个资金周期中，我们将保持我们的成功计划，同时增加计划评估、导师培训和招聘。具体目标：1.每年向梅奥招募9名新的毕业后见习科学家(4年内最多36名)，用于一项密集丰富的研究计划，以实现学生的个性化、学术和专业发展。实习科学家可能会接受一到两年的培训，具体取决于他们的需要。2.维持梅奥的预科项目，75%的毕业后学徒科学家进入博士或医学博士/博士项目，主要对基于实验室的研究或翻译研究感兴趣。3.让梅奥大学毕业后的学徒科学家掌握对成功启动和完成博士学位非常重要的技能。梅奥预科项目的每个方面都旨在提高学生作为科学家的创造力、自我效能感、承诺和目标。该计划提供专门设计的活动，以鼓励学生对与健康差距有关的研究领域的兴趣。4.在研究生院及以后，改善与梅奥大学毕业后的学徒科学家的长期联系和持续指导。我们将与梅奥国立卫生研究院资助的针对少数族裔博士生的IMSD项目以及梅奥多样性教育办公室协同实现这一目标。5.通过半结构化面谈继续进行内部和外部评估，确保增加Mayo准备活动的实用性、可行性、适当性和准确性。 与公共健康相关：这项研究教育计划将为应届大学毕业生提供1到2年的支持和专业技能发展。目标是帮助来自不同背景的学生(例如少数族裔、残疾人和弱势背景的个人)在博士水平上取得成功的生物医学研究职业，从而促进生物医学研究劳动力的多样化。

DESCRIPTION (provided by applicant): The majority of research training programs for individuals from underrepresented groups focus only on basic science research. Although critically important, these programs often fail to provide the motivational link between basic science research and improved health. The goal of the Mayo Post-Baccalaureate Research Education Program (PREP) is to increase the number of individuals from underrepresented groups who choose biomedical research careers, especially disease-oriented research. The program assists both those likely to succeed and those for whom the PREP experience may truly be pivotal in their career paths. Our hypothesis is that students from underrepresented groups increasingly choose disease-directed basic or translational research careers when they clearly see the value of this research in improving human health. Mayo's PREP is successful and mature, having been a unique cornerstone of institutional education diversity efforts since Mayo pioneered this program nationally in 1996. Mayo's ongoing commitment to diversity is supported from the highest executive level and has resulted in significant positive changes at the institution. The unique, highly-integrated clinical and biomedical research programs at Mayo provide an ideal environment to foster the career goals of apprentice scientists. Mayo's PhD graduate school, medical school, MSTP training site, and residency program are parts of the famed Mayo Clinic tertiary care center. Sustained funding of the Mayo PREP positively impacts diversity across the Mayo campus. The PREP synergizes with other ongoing Mayo diversity programs, including Mayo's NIH IMSD pre-doctoral program, URM summer research programs, and other institutionally-supported diversity education initiatives directed through Mayo's newly-formed Education Office for Diversity. Mayo's successful PREP and IMSD programs celebrate peer mentoring and mutual support between URM students across the summer undergraduate, clinical research, PREP, PhD, and MD/PhD research spectrum. This synergy is critical for student self-efficacy, identity as biomedical research scientists, and elucidation of the training path. PREP progress during the prior funding cycle, together with longitudinal data derived from 13 cohorts of prior PREP students, provides objective evidence of success in promoting graduate training leading to the PhD degree. During the next funding cycle we will maintain our successful program while increasing program evaluation, mentor training, and recruitment. Specific aims: 1. Recruit to Mayo 9 new post-baccalaureate apprentice scientists each year (total of up to 36 over 4 years) for a program of research with intensive enrichment toward individualized student academic and professional development. PREP apprentice scientists may receive one or two years of training, depending on their needs. 2. Maintain Mayo's PREP program where > 75% of post-baccalaureate apprentice scientists enter PhD or MD/PhD programs with a primary interest in laboratory-based or translational research. 3. Enrich Mayo's post-baccalaureate apprentice scientists with skills important for successful initiation and completion of the PhD degree. Each aspect of the Mayo PREP program is designed to enhance students' creativity, self-efficacy, commitment, and purpose as scientists. The program offers activities specifically designed to encourage student interest in research areas related to health disparities. 4. Improve long-term contact and ongoing mentoring of Mayo post-baccalaureate apprentice scientists through graduate school and beyond. We will achieve this goal in synergy with Mayo's NIH-funded IMSD program for minority pre-doctoral students, and with Mayo's Education Office for Diversity. 5. Continue internal and external evaluation with semi-structured interviews ensuring increased utility, feasibility, propriety, and accuracy of Mayo's PREP activities. PUBLIC HEALTH RELEVANCE: This research education program will provide 1 or 2 years of support and professional skills development for recent college graduates. The goal is to help students from diverse backgrounds (e.g. ethnic/racial minorities, individuals with disabilities, and individuals from disadvantaged backgrounds) to advance to successful biomedical research careers at the PhD level thus contributing to the diversification of the biomedical research workforce.