MECHANISMS OF PLASTICITY AND REPAIR AFTER SCI

SCI 后的可塑性和修复机制

• 批准号: 8364914
• 负责人: Scott R Whittemore
• 金额: $ 111.75万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364914
• 关键词: Area; Behavioral; Biometry; Centers of Research Excellence; Core Facility; D Cells; Development; Funding; Goals; Grant; Histology; Housing; Human; Human Resources; Image; Individual; Kentucky; Laboratories; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Nervous System Trauma; Operative Surgical Procedures; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Source; Spinal cord injury; Techniques; Technology; Tissues; Training; United States National Institutes of Health; Universities; Work; animal care; central nervous system injury; cost; injury and repair; innovative technologies; nervous system development; neurodevelopment; novel strategies; programs; repaired; research and development; translational study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this revised PSO grant is to expand the present COBRE-funded Kentucky Spinal Cord Injury Research Center (KSCIRC) Core facilities at the University of Louisville (UofL). We propose to broaden the scope of research that these Cores support in neural development and CNS injury, and 2) bring additional PIs into the Center both to enhance their research programs and to bring their new techniques and approaches to the COBRE PIs. We will increase the number of involved PIs from 8 to 22. The Cores will facilitate the research programs of both NIH funded and non-funded junior and more senior PIs in directions that would not be possible without the highly trained Core personnel. Each Core will be directed by a funded PI and housed in independent, dedicated laboratory space. All PIs will have access to these Cores. We will give priority access to junior and unfunded PIs. The UofL administration will make significant space and financial commitment to the COBRE/KSCIRC Core Facilities. The Cores are: A) Administration and Biostatistics, B) Surgery and Animal Care, C) Behavioral and Electrophysiological Assessment, D) Cell and Tissue Imaging and Histology, and E) Human Translational Studies. The specific aims are: 1. Support and enhance the scope of the strong ongoing UofL NINDS and non-NINDS funded research in the areas of nervous system injury and repair, including our continuing development of innovative technology. 2. Make our technologies available to additional UofL neuroscientists working in other areas of nervous system development and repair to facilitate their individual research programs with novel approaches. 3. Facilitate the development of the research programs of junior and more senior unfunded Investigators. 4. Enhance collaborative opportunities between PIs that utilize these Core facilities.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项修订后的PSO赠款的目标是扩大目前的COBRE-funded肯塔基州脊髓损伤研究中心（KSCIRC）在路易斯维尔大学（UofL）的核心设施。我们建议扩大这些核心支持神经发育和中枢神经系统损伤的研究范围，2）将更多的PI引入中心，以加强他们的研究计划，并将他们的新技术和方法引入COBRE PI。我们会把参与计划的私家侦探数目由8名增至22名。核心将促进NIH资助和非资助的初级和高级PI的研究计划，如果没有训练有素的核心人员，这些研究计划是不可能的。每个核心将由一名受资助的PI指导，并安置在独立的专用实验室空间内。所有PI都可以访问这些核心。我们将优先考虑初级和无资金的PI。UofL管理部门将为COBRE/KSCIRC核心设施提供大量空间和资金。 核心是：A）给药和生物统计学，B）手术和动物护理，C）行为和电生理学评估，D）细胞和组织成像和组织学，以及E）人体转化研究。具体目标是：1.支持和加强强大的持续UofL NINDS和非NINDS资助的研究在神经系统损伤和修复领域的范围，包括我们的创新技术的持续发展。2.使我们的技术提供给其他UofL神经科学家在神经系统发育和修复的其他领域工作，以促进他们的个人研究计划与新的方法。3.促进初级和更高级的无资金研究者的研究计划的发展。4.加强利用这些核心设施的PI之间的合作机会。