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Mechanisms of plasticity and repair after SCI

SCI后的可塑性和修复机制

基本信息

批准号：
8901221
负责人：
Scott R Whittemore
金额：
$ 103.48万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8901221
关键词：
Area Behavioral Biometry Cancer Grant Supplements (P30)Centers of Research Excellence Core Facility D Cells Development Extramural Activities Faculty Funding Goals Grant Histology Housing Human Human Resources Image Individual Investments Kentucky Laboratories Life Mentorship National Institute of Neurological Disorders and Stroke Nervous System Trauma Neurosciences Research Operative Surgical Procedures Paralysed Rattus Rehabilitation Research Rehabilitation therapy Research Research Infrastructure Research Personnel Resources Rodent Secure Services Spinal cord injury Techniques Technology Therapeutic Tissues Training Translating United States United States National Institutes of Health Universities Work animal care central nervous system injury disability injury and repair innovation innovative technologies insight mortality nervous system development neurodevelopment novel novel strategies programs rehabilitation strategy repaired research and development translational study

项目摘要

The goal of this revised PSO grant is to expand the present COBRE-funded Kentucky Spinal Cord Injury Research Center (KSCIRC) Core facilities at the University of Louisville (UofL). We propose to broaden the scope of research that these Cores support in neural development and CNS injury, and 2) bring additional PIs into the Center both to enhance their research programs and to bring their new techniques and approaches to the COBRE PIs. We will increase the number of involved PIs from 8 to 22. The Cores will facilitate the research programs of both NIH funded and non-funded junior and more senior PIs in directions that would not be possible without the highly trained Core personnel. Each Core will be directed by a funded PI and housed in independent, dedicated laboratory space. All PIs will have access to these Cores. We will give priority access to junior and unfunded PIs. The UofL administration will make significant space and financial commitment to the COBRE/KSCIRC Core Facilities. The Cores are: A) Administration and Biostatistics, B) Surgery and Animal Care, C) Behavioral and Electrophysiological Assessment, D) Cell and Tissue Imaging and Histology, and E) Human Translational Studies. The specific aims are: 1. Support and enhance the scope of the strong ongoing UofL NINDS and non-NINDS funded research in the areas of nervous system injury and repair, including our continuing development of innovative technology. 2. Make our technologies available to additional UofL neuroscientists working in other areas of nervous system development and repair to facilitate their individual research programs with novel approaches. 3. Facilitate the development of the research programs of junior and more senior unfunded Investigators. 4. Enhance collaborative opportunities between PIs that utilize these Core facilities.

这项修订后的PSO赠款的目标是扩大目前的COBRE-funded肯塔基州脊髓损伤研究中心（KSCIRC）路易斯维尔大学（UofL）的核心设施。我们建议扩阔这些核心支持神经发育和CNS损伤的研究范围，以及2）带来额外的 PI进入中心，以加强他们的研究计划，并带来他们的新技术，接近COBRE PI。我们会把参与计划的私家侦探数目由8名增至22名。核心将促进NIH资助和非资助的初级和高级PI的研究计划，没有训练有素的核心人员是不可能的每个核心都将由一个受资助的 PI和圈养在独立的，专用的实验室空间。所有PI都可以访问这些核心。我们将优先访问初级和无资金的PI。UofL管理部门将在这方面提供重要的空间，对COBRE/KSCIRC核心设施的财务承诺。核心是：A）行政和生物统计学，B）手术和动物护理，C）行为和电生理学评估，D）细胞和组织成像和组织学，以及E）人类转化研究。具体目标是：1.支持和扩大UofL NINDS和非NINDS资助的研究领域的范围，神经系统损伤和修复，包括我们不断发展的创新技术。2.使我们的技术可用于其他UofL神经科学家在神经系统的其他领域工作开发和修复，以促进他们的个人研究计划与新的方法。3.促进初级和更高级的无资金研究者的研究计划的发展。4.增强利用这些核心设施的PI之间的协作机会。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Somatostatin and corticotrophin releasing hormone cell types are a major source of descending input from the forebrain to the parabrachial nucleus in mice.

生长抑素和促肾上腺皮质激素释放激素细胞类型是小鼠从前脑到臂旁核下降输入的主要来源。

DOI：
10.1093/chemse/bju038
发表时间：
2014
期刊：
Chemical senses
影响因子：
3.5
作者：
Magableh,Ali;Lundy,Robert
通讯作者：
Lundy,Robert

Heart rate and blood pressure response improve the prediction of orthostatic cardiovascular dysregulation in persons with chronic spinal cord injury.

DOI：
10.14814/phy2.14617
发表时间：
2020-10
期刊：
Physiological reports
影响因子：
2.5
作者：
Wang S;Wecht JM;Legg Ditterline B;Ugiliweneza B;Maher MT;Lombard AT;Aslan SC;Ovechkin AV;Bethke B;Gunter JTH;Harkema SJ
通讯作者：
Harkema SJ

Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation.

DOI：
10.1038/s41467-017-02033-x
发表时间：
2017-12-06
期刊：
Nature communications
影响因子：
16.6
作者：
Pocratsky AM;Burke DA;Morehouse JR;Beare JE;Riegler AS;Tsoulfas P;States GJR;Whittemore SR;Magnuson DSK
通讯作者：
Magnuson DSK

Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.

DOI：
10.1016/j.exger.2015.01.044
发表时间：
2015-03
期刊：
EXPERIMENTAL GERONTOLOGY
影响因子：
3.9
作者：
Aird, Allison L.;Nevitt, Christopher D.;Christian, Katelyn;Williams, Stuart K.;Hoying, James B.;LeBlanc, Amanda J.
通讯作者：
LeBlanc, Amanda J.

Wnt5a Regulates the Assembly of Human Adipose Derived Stromal Vascular Fraction-Derived Microvasculatures.

DOI：
10.1371/journal.pone.0151402
发表时间：
2016
期刊：
PloS one
影响因子：
3.7
作者：
Ramakrishnan VM;Tien KT;McKinley TR;Bocard BR;McCurry TM;Williams SK;Hoying JB;Boyd NL
通讯作者：
Boyd NL