NEUROSCIENCE CORE CENTER

神经科学核心中心

• 批准号: 8364909
• 负责人: FRANCIS W FLYNN
• 金额: $ 102.05万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364909
• 关键词: Address; Alzheimer' s Disease; Biological Models; Biomedical Research; Brain; Centers of Research Excellence; Collaborations; Data; Development; Disease; Electron Microscope; Faculty; Fostering; Funding; Goals; Grant; Human; Huntington Disease; Life; Mentors; Microscopy; Molecular; Morphology; National Center for Research Resources; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurons; Neurosciences; Optics; Parkinson Disease; Pathway interactions; Phase; Positioning Attribute; Principal Investigator; Prion Diseases; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Source; Staging; Structure; Synapses; Synaptic plasticity; Therapeutic Intervention; United States National Institutes of Health; Universities; Wyoming; career; career development; chronic pain; cost; experience; innovation; meetings; nervous system disorder; programs; protein misfolding; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This Transition Center PSO application is a continuation of the Neuroscience COBRE at the University of Wyoming (UW). The Center goals were to develop a critical mass of neuroscience faculty, foster biomedical research in neurological disorders, increase NIH funding at UW, establish a Career Mentoring program, and develop the required research infrastructure, specifically the Microscopy Core. These goals have been met and the success of the Neuroscience Center and the development of the Microscopy Core is directly attributable to the NCRR COBRE grant, and secondly to the significant institutional commitment. UW provided 7 state-funded, tenure track neuroscience positions to the Center and state funding for the Microscopy Core Director. The Microscopy Core is essential to the success of the Neuroscience Center investigators and additional biomedical researchers on campus. The Core Director provides technical guidance in the use of the optical and electron microscopes in the facility. The Microscopy Core has enabled investigators to identify how normal synaptic connections are formed and the effects of protein misfolding on neuronal morphology in neurodegeneration. The Phase III grant will support Career Development, Pilot Research Projects (for assembling preliminary data for grants), and the Microscopy Core. Plans to sustain the Core following the completion of the Phase III transition grant are identified. Research progress of Center investigators has led to new hypotheses and experimental questions pertaining to how nervous system morphology and function changes with the life-stage, disease, experience, and experimental manipulation. The Neuroscience Center will provide the structure for building innovative and productive collaborations that address major biomedical issues related to mechanisms of synaptic plasticity, neurodegeneration, and chronic pain. Prion diseases are a prototypic protein misfolding disease and they share many molecular and pathological features with the more frequent human neurodegenerative disorders, e.g. Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). New collaborative projects are identified that will utilize model systems that enable us to bridge between protein misfolding pathways and the downstream functional effects on neuronal activity and brain circuits, and common ways for therapeutic intervention.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：此过渡中心PSO申请是怀俄明州大学（UW）神经科学COBRE的延续。该中心的目标是发展神经科学教师的临界质量，促进神经系统疾病的生物医学研究，增加NIH在华盛顿大学的资金，建立职业指导计划，并开发所需的研究基础设施，特别是显微镜核心。这些目标已经实现，神经科学中心的成功和显微镜核心的发展直接归功于NCRR COBRE赠款，其次是重要的机构承诺。华盛顿大学提供了7个国家资助，终身跟踪神经科学的立场，该中心和国家资助的显微镜核心主任。显微镜核心是必不可少的神经科学中心的研究人员和校园内的其他生物医学研究人员的成功。核心主任在设施中使用光学和电子显微镜方面提供技术指导。显微镜核心使研究人员能够确定正常的突触连接是如何形成的，以及蛋白质错误折叠对神经退行性疾病中神经元形态的影响。第三阶段赠款将支持职业发展，试点研究项目（用于收集赠款的初步数据）和显微镜核心。确定了在第三阶段过渡赠款完成后维持核心方案的计划。中心研究人员的研究进展导致了新的假设和实验问题，涉及神经系统形态和功能如何随着生命阶段，疾病，经验和实验操作而变化。神经科学中心将为建立创新和富有成效的合作提供结构，解决与突触可塑性，神经退行性和慢性疼痛机制相关的主要生物医学问题。朊病毒病是一种典型的蛋白质错误折叠疾病，与阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）等常见的人类神经退行性疾病有许多共同的分子和病理特征。确定了新的合作项目，这些项目将利用模型系统，使我们能够在蛋白质错误折叠途径与对神经元活动和脑回路的下游功能影响以及治疗干预的常见方式之间架起桥梁。