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NEUROSCIENCE CORE CENTER

神经科学核心中心

基本信息

批准号：
8879165
负责人：
FRANCIS W FLYNN
金额：
$ 98.97万
依托单位：
UNIVERSITY OF WYOMING
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8879165
关键词：
Address Alzheimer&apos s Disease Biological Models Biomedical Research Brain Centers of Research Excellence Collaborations Data Development Disease Electron Microscope Faculty Fostering Funding Goals Grant Health Human Huntington Disease Life Mentors Microscopy Molecular Morphology National Center for Research Resources Nerve Degeneration Nervous system structure Neurodegenerative Disorders Neurons Neurosciences Optics Parkinson Disease Pathway interactions Phase Positioning Attribute Prion Diseases Research Research Infrastructure Research Personnel Research Project Grants Staging Structure Synapses Synaptic plasticity Therapeutic Intervention United States National Institutes of Health Universities Wyoming career career development chronic pain experience innovation meetings nervous system disorder programs protein misfolding relating to nervous system success

项目摘要

DESCRIPTION (provided by applicant): This Transition Center PSO application is a continuation of the Neuroscience COBRE at the University of Wyoming (UW). The Center goals were to develop a critical mass of neuroscience faculty, foster biomedical research in neurological disorders, increase NIH funding at UW, establish a Career Mentoring program, and develop the required research infrastructure, specifically the Microscopy Core. These goals have been met and the success of the Neuroscience Center and the development of the Microscopy Core is directly attributable to the NCRR COBRE grant, and secondly to the significant institutional commitment. UW provided 7 state-funded, tenure track neuroscience positions to the Center and state funding for the Microscopy Core Director. The Microscopy Core is essential to the success of the Neuroscience Center investigators and additional biomedical researchers on campus. The Core Director provides technical guidance in the use of the optical and electron microscopes in the facility. The Microscopy Core has enabled investigators to identify how normal synaptic connections are formed and the effects of protein misfolding on neuronal morphology in neurodegeneration. The Phase III grant will support Career Development, Pilot Research Projects (for assembling preliminary data for grants), and the Microscopy Core. Plans to sustain the Core following the completion of the Phase III transition grant are identified. Research progress of Center investigators has led to new hypotheses and experimental questions pertaining to how nervous system morphology and function changes with the life-stage, disease, experience, and experimental manipulation. The Neuroscience Center will provide the structure for building innovative and productive collaborations that address major biomedical issues related to mechanisms of synaptic plasticity, neurodegeneration, and chronic pain. Prion diseases are a prototypic protein misfolding disease and they share many molecular and pathological features with the more frequent human neurodegenerative disorders, e.g. Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). New collaborative projects are identified that will utilize model systems that enable us to bridge between protein misfolding pathways and the downstream functional effects on neuronal activity and brain circuits, and common ways for therapeutic intervention.

描述（由申请人提供）：此过渡中心PSO申请是怀俄明州大学（UW）神经科学COBRE的延续。该中心的目标是发展神经科学教师的临界质量，促进神经系统疾病的生物医学研究，增加NIH在华盛顿大学的资金，建立职业指导计划，并开发所需的研究基础设施，特别是显微镜核心。这些目标已经实现，神经科学中心的成功和显微镜核心的发展直接归功于NCRR COBRE赠款，其次是重要的机构承诺。华盛顿大学提供了7个国家资助，终身跟踪神经科学的立场，该中心和国家资助的显微镜核心主任。显微镜核心是必不可少的神经科学中心的研究人员和校园内的其他生物医学研究人员的成功。核心主任在设施中使用光学和电子显微镜方面提供技术指导。显微镜核心使研究人员能够确定正常突触连接是如何形成的，以及蛋白质错误折叠对神经退行性疾病中神经元形态的影响。第三阶段赠款将支持职业发展，试点研究项目（用于收集赠款的初步数据）和显微镜核心。确定了在第三阶段过渡赠款完成后维持核心方案的计划。中心研究人员的研究进展导致了新的假设和实验问题，涉及神经系统形态和功能如何随着生命阶段，疾病，经验和实验操作而变化。神经科学中心将为建立创新和富有成效的合作提供结构，解决与突触可塑性，神经退行性和慢性疼痛机制相关的主要生物医学问题。朊病毒病是一种典型的蛋白质错误折叠疾病，与阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）等常见的人类神经退行性疾病有许多共同的分子和病理特征。确定了新的合作项目，这些项目将利用模型系统，使我们能够在蛋白质错误折叠途径与对神经元活动和脑回路的下游功能影响以及治疗干预的常见方式之间架起桥梁。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.

感染弓形虫的亨廷顿疾病小鼠表现出早期的Kynurenine途径激活，CD8+ T细胞反应改变和过早死亡。

DOI：
10.1371/journal.pone.0162404
发表时间：
2016
期刊：
PloS one
影响因子：
3.7
作者：
Donley DW;Olson AR;Raisbeck MF;Fox JH;Gigley JP
通讯作者：
Gigley JP

Exposure to a diet high in fat attenuates dendritic spine density in the medial prefrontal cortex.

DOI：
10.1007/s00429-016-1208-y
发表时间：
2017-03
期刊：
Brain structure & function
影响因子：
3.1
作者：
Dingess PM;Darling RA;Kurt Dolence E;Culver BW;Brown TE
通讯作者：
Brown TE

The search for a neural basis of communication: Learning, memory, perception and performance of vocal signals.

寻找沟通的神经基础：声音信号的学习、记忆、感知和表现。

DOI：
10.1121/1.4800998
发表时间：
2013
期刊：
Proceedings of meetings on acoustics. Acoustical Society of America
影响因子：
0
作者：
Prather,Jonathan
通讯作者：
Prather,Jonathan

Does salt have a permissive role in the induction of puberty?

盐对青春期的诱导有许可作用吗？

DOI：
10.1016/j.mehy.2015.06.029
发表时间：
2015
期刊：
Medical hypotheses
影响因子：
4.7
作者：
Pitynski,Dori;Flynn,FrancisW;Skinner,DonalC
通讯作者：
Skinner,DonalC

Male mate preferences in mutual mate choice: finches modulate their songs across and within male-female interactions.

雄性在相互择偶中的偏好：雀类在雌雄互动中调节它们的歌曲。

DOI：
10.1016/j.anbehav.2014.08.016
发表时间：
2014
期刊：
Animal behaviour
影响因子：
2.5
作者：
Heinig,Abbie;Pant,Santosh;Dunning,Jeffery;Bass,Aaron;Coburn,Zachary;Prather,JonathanF
通讯作者：
Prather,JonathanF