NEUROSCIENCE CORE CENTER

神经科学核心中心

• 批准号: 8235769
• 负责人: FRANCIS W FLYNN
• 金额: $ 98.84万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235769
• 关键词: Address; Alzheimer' s Disease; Biological Models; Biomedical Research; Brain; Centers of Research Excellence; Collaborations; Data; Development; Disease; Electron Microscope; Faculty; Fostering; Funding; Goals; Grant; Health; Human; Huntington Disease; Life; Mentors; Microscopy; Molecular; Morphology; National Center for Research Resources; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurons; Neurosciences; Optics; Parkinson Disease; Pathway interactions; Phase; Positioning Attribute; Prion Diseases; Research; Research Infrastructure; Research Personnel; Research Project Grants; Staging; Structure; Synapses; Synaptic plasticity; Therapeutic Intervention; United States National Institutes of Health; Universities; Wyoming; career; career development; chronic pain; experience; innovation; meetings; nervous system disorder; programs; protein misfolding; relating to nervous system; success

DESCRIPTION (provided by applicant): This Transition Center PSO application is a continuation of the Neuroscience COBRE at the University of Wyoming (UW). The Center goals were to develop a critical mass of neuroscience faculty, foster biomedical research in neurological disorders, increase NIH funding at UW, establish a Career Mentoring program, and develop the required research infrastructure, specifically the Microscopy Core. These goals have been met and the success of the Neuroscience Center and the development of the Microscopy Core is directly attributable to the NCRR COBRE grant, and secondly to the significant institutional commitment. UW provided 7 state-funded, tenure track neuroscience positions to the Center and state funding for the Microscopy Core Director. The Microscopy Core is essential to the success of the Neuroscience Center investigators and additional biomedical researchers on campus. The Core Director provides technical guidance in the use of the optical and electron microscopes in the facility. The Microscopy Core has enabled investigators to identify how normal synaptic connections are formed and the effects of protein misfolding on neuronal morphology in neurodegeneration. The Phase III grant will support Career Development, Pilot Research Projects (for assembling preliminary data for grants), and the Microscopy Core. Plans to sustain the Core following the completion of the Phase III transition grant are identified. Research progress of Center investigators has led to new hypotheses and experimental questions pertaining to how nervous system morphology and function changes with the life-stage, disease, experience, and experimental manipulation. The Neuroscience Center will provide the structure for building innovative and productive collaborations that address major biomedical issues related to mechanisms of synaptic plasticity, neurodegeneration, and chronic pain. Prion diseases are a prototypic protein misfolding disease and they share many molecular and pathological features with the more frequent human neurodegenerative disorders, e.g. Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). New collaborative projects are identified that will utilize model systems that enable us to bridge between protein misfolding pathways and the downstream functional effects on neuronal activity and brain circuits, and common ways for therapeutic intervention.

描述（由申请人提供）：这个过渡中心PSO申请是怀俄明大学（UW）神经科学COBRE的延续。该中心的目标是培养神经科学师资队伍，促进神经疾病的生物医学研究，增加美国国立卫生研究院在华盛顿大学的资助，建立职业指导计划，并发展所需的研究基础设施，特别是显微镜核心。这些目标已经实现，神经科学中心的成功和显微镜核心的发展直接归功于NCRR COBRE拨款，其次是重要的机构承诺。华盛顿大学为该中心提供了7个国家资助的终身神经科学职位，并为显微镜核心主任提供了国家资助。显微镜核心是必不可少的成功神经科学中心的调查人员和其他生物医学研究人员在校园。核心主任为该设施使用光学和电子显微镜提供技术指导。显微镜核心使研究人员能够确定正常突触连接是如何形成的，以及蛋白质错误折叠对神经变性中神经元形态的影响。第三阶段资助将支持职业发展、试点研究项目（为资助收集初步数据）和显微镜核心。确定了在第三阶段过渡赠款完成后维持核心的计划。研究人员在神经系统形态和功能如何随生命阶段、疾病、经历和实验操作而变化方面取得了新的假设和实验问题。神经科学中心将为建立创新和富有成效的合作提供结构，解决与突触可塑性，神经变性和慢性疼痛机制相关的主要生物医学问题。朊病毒疾病是一种典型的蛋白质错误折叠疾病，它们与阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）等更为常见的人类神经退行性疾病具有许多分子和病理特征。我们确定了新的合作项目，将利用模型系统，使我们能够在蛋白质错误折叠途径和对神经元活动和脑回路的下游功能影响之间架起桥梁，并为治疗干预提供常见方法。