Central Control of Mobility in Aging

老龄化过程中流动性的中央控制

• 批准号: 8039795
• 负责人: Roee Holtzer
• 金额: $ 68.1万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8039795
• 关键词: Age; Aging; Anterior; Attention; Basal Ganglia; Brain; Brain imaging; Clinical Practice Guideline; Clinical assessments; Cognitive; Communities; Elderly; Equipment and supply inventories; Evaluation; Failure; Fatigue; Functional Magnetic Resonance Imaging; Gait; Individual; Intervention; Knowledge; Lead; Light; Link; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Methods; Motion; Near-Infrared Spectroscopy; Patient Self-Report; Performance; Recruitment Activity; Reporting; Resolution; Risk; Risk Assessment; Sampling; System; Task Performances; Testing; Visit; Walking; Work; adverse outcome; base; blood oxygenation level dependent response; cognitive function; cohort; design; disability; executive function; follow-up; frontal lobe; insight; neuroimaging; novel; relating to nervous system; secondary outcome

DESCRIPTION (provided by applicant): We propose to examine the effects of executive control and fatigue on the maintenance of mobility and risk of mobility disability in older adults and their underlying brain substrates. Our overall working hypothesis is that mobility, executive control, and fatigue are closely linked through the frontal cortex-basal ganglia system in older adults. We propose to recruit 450 non- demented community-residing individuals age 70 years and older for baseline and annual follow-ups over the 5-year study period. Study measures will be administered in each yearly evaluation to identify cross-sectional and longitudinal effects of executive control and fatigue on mobility (aim 1). Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (aim 2). Structural and functional MRI will be administered to a subsample (n=70) at baseline to augment our assessment of brain correlates of mobility. PUBLIC HEALTH RELEVANCE: At present, cognitive function and fatigue are not routinely included in the risk assessment of mobility decline and disability in older adults. Furthermore, current mobility interventions do not specifically target cognitive function or fatigue. If successful, the findings of this proposal may substantially impact clinical practice guidelines. This proposal is designed to shed light on specific structural and functional brain substrates implicated in mobility. As such, we hope that our findings will further knowledge of causal and potentially modifiable predictors of mobility decline and disability in older adults.

描述（由申请人提供）：我们建议检查执行控制和疲劳对老年人及其潜在大脑基质的移动性和移动性残疾风险的维持的影响。我们的总体工作假设是，在老年人中，移动性、执行控制和疲劳通过额叶皮层-基底神经节系统密切相关。我们建议招募450名年龄在70岁及以上的非痴呆社区居民，在5年的研究期间进行基线和年度随访。研究措施将在每年的评估中进行，以确定执行控制和疲劳对移动性的横截面和纵向影响（目的1）。在每次研究访视中将使用功能性近红外光谱（FNIRS）来识别运动中PFC与活动性的功能相关性（目的2）。将在基线时对子样本（n=70）进行结构和功能MRI，以增强我们对大脑活动相关性的评估。 公共卫生相关性：目前，认知功能和疲劳并没有被常规纳入老年人活动能力下降和残疾的风险评估中。此外，目前的移动性干预措施并不专门针对认知功能或疲劳。如果成功，该提案的结果可能会对临床实践指南产生重大影响。这个提议旨在阐明与移动性有关的特定结构和功能大脑基质。因此，我们希望我们的研究结果将进一步了解老年人活动能力下降和残疾的因果关系和潜在的可修改预测因素。