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Central Control of Mobility in Aging

Central Control of Mobility in Aging
老龄化过程中流动性的中央控制
批准号：
9141094
负责人：
Roee Holtzer
金额：
$28.18万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-03-01 至 2017-08-31
来源：
https://reporter.nih.gov/project-details/9141094
关键词：
AgeAgingAnteriorAttentionBasal GangliaBrainBrain imagingClinical Practice GuidelineClinical assessmentsCognitiveCommunitiesElderlyEquipment and supply inventoriesEvaluationFailureFatigueFunctional Magnetic Resonance ImagingGaitHealthIndividualInterventionKnowledgeLeadLightLinkMagnetic Resonance ImagingMaintenanceMeasuresMediatingMethodsModelingMotionNear-Infrared SpectroscopyOutcomePatient Self-ReportPerformanceQuestionnairesRecruitment ActivityReportingResolutionRiskRisk AssessmentSamplingSystemTask PerformancesTestingVisitWalkingWorkadverse outcomebaseblood oxygenation level dependent responsecognitive functioncognitive performancecognitive processcohortdesigndisabilityexecutive functionfollow-upfrontal lobeinsightneuroimagingnovelrelating to nervous systemsecondary outcomesustained attention

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DESCRIPTION (provided by applicant): We propose to examine the effects of executive control and fatigue on the maintenance of mobility and risk of mobility disability in older adults and their underlying brain substrates. Our overall working hypothesis is that mobility, executive control, and fatigue are closely linked through the frontal cortex-basal ganglia system in older adults. We propose to recruit 450 non- demented community-residing individuals age 70 years and older for baseline and annual follow-ups over the 5-year study period. Study measures will be administered in each yearly evaluation to identify cross-sectional and longitudinal effects of executive control and fatigue on mobility (aim 1). Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (aim 2). Structural and functional MRI will be administered to a subsample (n=70) at baseline to augment our assessment of brain correlates of mobility.
期刊论文(83)
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会议论文
Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI.
DOI： 10.1111/jon.12432
发表时间： 2017-09
期刊： Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子： --
作者： [Chen M, Blumen HM, Izzetoglu M, Holtzer R]
通讯作者： Holtzer R
Reply to Cognitive Reserve: Predictor of Onset of Postoperative Delirium in Older Adults?
回复认知储备：老年人术后谵妄发生的预测因子？
DOI： 10.1111/jgs.14593
发表时间： 2017
期刊： Journal of the American Geriatrics Society
影响因子： 6.3
作者： [Verghese,Joe]
通讯作者： Verghese,Joe
Quantitative trunk sway and prediction of incident falls in older adults.
老年人躯干摇摆的定量和跌倒事件的预测。
DOI： 10.1016/j.gaitpost.2017.07.115
发表时间： 2017
期刊： Gait & posture
影响因子： 2.4
作者： [Mahoney,JeannetteR, Oh-Park,Mooyeon, Ayers,Emmeline, Verghese,Joe]
通讯作者： Verghese,Joe
Association Between Red Blood Cell Indices and Quantitative Gait Variables in Older Adults.
红细胞指数与老年人定量步态变量之间的关联。
DOI： 10.1111/jgs.13545
发表时间： 2015
期刊： Journal of the American Geriatrics Society
影响因子： 6.3
作者： [Onuoha,Somechukwu, Verghese,Joe]
通讯作者： Verghese,Joe
共 43 条
    Collaborative Research: SCH: Assessment of Cognitive Decline using Multimodal Neuroimaging with Embedded Artificial Intelligence
    • 批准号：
      10438005
    • 项目类别：
    • 资助金额：
      $30.19万
    • 财政年份：
      2022
    • 负责人：
      Roee Holtzer
    • 依托单位：
      VILLANOVA UNIVERSITY
    Central Control and Neuroinflammatory Mechanisms of Locomotion in Older Adults with HIV
    Brain predictors of mobility and falls in older adults with multiple sclerosis
    Brain Predictors of Mobility and Falls in Older Adults with Multiple Sclerosis
    海外基金