North Carolina A&T University-Wake Forest Cancer Center partnership (1of 2)

北卡罗来纳州A

• 批准号: 7913026
• 负责人: STEVEN A AKMAN
• 金额: $ 25.55万
• 依托单位: NORTH CAROLINA AGRI & TECH ST UNIV
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7913026
• 关键词: Achievement; African American; Agriculture; Animal Cancer Model; Arts; Biology; Brain Neoplasms; CCL7 gene; Cancer Biology; Cancer Center; Cell Mobility; Chemistry; Chemopreventive Agent; Collaborations; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Computational Biology; Development; Doctor of Philosophy; Educational process of instructing; Enrollment; Faculty; Fostering; Funding; Glioblastoma; Historically Black Colleges and Universities; Joints; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Master' s Degree; Mentors; Minority; North Carolina; Pilot Projects; Research; Research Project Grants; Resistance; Role; Scientist; Students; Therapeutic; Training; Universities; Writing; anticancer research; cancer genomics; cancer health disparity; career; career development; design; forest; health disparity; interest; novel; outreach; professor; programs; transcription factor

This P20 proposal presents a research and educational partnership between the Wake Forest University Comprehensive Cancer Center (WFUCCC) and the Departments of Biology and Chemistry of North Carolina Agricultural and Technical University (NC A&T). The objectives of the partnership are: (1) to foster cancer research collaborations between WFUCCC and NC A&T, especially research focused on cancer disparities and to facilitate the career development of minority cancer research faculty at NC A&T through collaborations with and mentoring provided by the WFUCCC; (2) to foster interest in obtaining a PhD in cancer biology among minority undergraduate and Master's degree students at NC A&T. To achieve the first objective, the P20 will provide pilot funds for two collaborative research projects: (1) Drs. Suzy Torti and Yong Chen of the WFUCCC will mentor and collaborate with Dr. Marion Franks, Assistant Professor of Chemistry at NC A&T, on a project to synthesize and evaluate novel benzylidenes as prostate cancer chemopreventive agents; (2) Dr. Waldemar Debinski, Director of the Brain Tumor Center of the WFUCCC, will mentor and collaborate with Dr. Patrick Martin, Assistant Professor of Biology at NC A&T on a project to understand the role of transcription factor Fral in glioblastoma cell mobility and resistance to therapeutics.. To achieve the second objective: (1) Selected RISE, MARC, and BLEND program undergraduates at NC A&T will participate in wet laboratory, computational biology, or health disparity outreach projects mentored by WFUCCC faculty; (2) Each pilot project team will select at least one NC A&T Master's degree student to participate in the project. The students will be offered the option of continued participation in the projects as PhD students in Cancer Biology at WFU; (3) WFUCCC and NC A&T faculty will collaborate to develop didactic teaching modules in cancer genomics and animal models of cancer for currently ongoing coursework at NC A&T. By the conclusion of the P20 it is expected that: (1) Drs. Franks and Martin and their WFUCCC collaborators will be writing joint ROls; (2) The WFUCCC and NC A&T will be writing an R25 bridge application to support enrollment of NC A&T students in the PhD program in Cancer Biology at WFU.

该P20提案提出了Wake Forest University之间的研究和教育伙伴关系 综合癌症中心（WFUCCC）以及北卡罗来纳州生物学和化学部门 农业技术大学（NC A＆T）。合作伙伴关系的目标是：（1）促进癌症 WFUCCC和NC A＆T之间的研究合作，尤其是针对癌症差异的研究和 通过与和 WFUCCC提供的指导； （2）促进少数群体中癌症生物学博士学位的兴趣 NC A＆T的本科生和硕士学位学生。为了实现第一个目标，P20将提供飞行员 两个协作研究项目的资金：（1）Drs。 WFUCCC的Suzy Torti和Yong Chen将指导和 NC A＆T化学助理教授Marion Franks博士在合成和合成的项目中 评估新颖的苄基烯作为前列腺癌化学预防剂； （2）Waldemar Debinski博士 WFUCCC的脑肿瘤中心将指导和与助理教授帕特里克·马丁博士合作 NC A＆T在一个项目上的生物学，以了解转录因子弗拉尔在胶质母细胞瘤细胞中的作用 移动性和对治疗学的抵抗力。 NC A＆T的课程本科生将参加湿实验室，计算生物学或健康差异 WFUCCC教师指导的外展项目； （2）每个飞行员项目团队将至少选择一个NC A＆T 硕士学位学生参加该项目。将向学生提供继续的选择 作为WFU的癌症生物学博士学位学生参加这些项目； （3）WFUCCC和NC A＆T教师将 合作开发癌症基因组学和动物模型的教学模块，目前 NC A＆T正在进行的课程。根据P20的结论，可以预期：（1）Drs。弗兰克斯和马丁和 他们的WFUCCC合作者将撰写联合ROL； （2）WFUCCC和NC A＆T将编写R25 支持NC A＆T学生在WFU的癌症生物学博士学位计划中的桥梁应用。