Training Program in Cancer Biology

描述（由申请人提供）：癌症生物学培训计划是一个针对博士后和博士后的培训计划，旨在培养研究人员，他们将在他们的研究生涯中专注于与癌症问题相关的生物和化学问题。本课程旨在让学员了解人类癌症的基础科学问题与临床问题之间的关系。该项目位于维克森林大学综合癌症中心的癌症生物系；所有培训教员要么是癌症生物学系的主要成员，要么是癌症生物学系的交叉任命教员。交叉任命的人员来自生物化学、化学、皮肤病学、基因组学、微生物学、病理学、放射生物学和外科等部门。受训者包括希望补充其癌症研究训练的博士研究生和博士或医学博士博士后。所有博士预科生都是维克森林大学研究生院授予的癌症生物学博士学位的候选人。Pre- and - postdoctoral training结合了研究，研讨会/专题讨论会的参与和教学课程，涵盖DNA损伤和修复，癌细胞生物学，信号转导，细胞周期控制，生化药理学，肿瘤免疫学，基因治疗生物信息学，以及人类癌症临床和流行病学问题的概述。研究由院系教师导师指导；具体任务由项目执行委员会作出。培训计划的主要特点包括广泛的指导和评估过程，以及具有活跃的临床和基础科学研究项目的培训教师。该培训计划通过以下方式实现了美国国家癌症研究所的目标：(1)培养研究人员，使他们能够在研究生涯中专注于癌症问题；(2)提供跨越化学-生物界面的教育；(3)强调基础科学与人类癌症临床问题之间的联系。培训项目在最初的资助周期中取得了一些显著的成功，这些成功将延续到当前的资助周期，包括：(1)显著增加少数族裔学员的入学率；（二）毕业后进入学术机构担任教职的博士后；(3)为2名博士后化学家提供生物学培训，为2名癌症生物学博士生提供化学培训。

DESCRIPTION (provided by applicant): The Training Program in Cancer Biology is a program for pre- and postdoctoral trainees designed to train investigators who will focus on biological and chemical issues specifically related to the problem of cancer during their research careers. This program imparts to trainees an understanding of the relationships between the basic scientific problems and clinical issues of human cancer. The Program is anchored in the Department of Cancer Biology of the Wake Forest University Comprehensive Cancer Center; all training faculty are either primary Cancer Biology Department members or are cross-appointed in Cancer Biology. Cross appointees come from the Departments of Biochemistry, Chemistry, Dermatology, Genomics, Microbiology, Pathology, Radiation Biology, and Surgery. Trainees include pre-doctoral Ph.D. candidates and Ph.D. or M.D. postdoctoral fellows who wish to supplement their training in cancer research. All pre-doctoral trainees are candidates for a Ph.D. in Cancer Biology conferred by the Graduate School of Wake Forest University. Pre- and postdoctoral traineeships combine research, seminar/symposia participation plus didactic coursework covering DNA damage and repair, cancer cell biology, signal transduction, cell cycle control, biochemical pharmacology, tumor immunology, gene therapy bioinformatics, and an overview of clinical and epidemiologic issues in human cancer. Research is supervised by Departmental faculty mentors; specific assignments are made by the Program executive committee. Key features of the Training Program include an extensive mentoring and evaluation process and a training faculty with active research programs that mesh clinical and basic science. This training program addresses the goals of the National Cancer Institute by: (1) producing investigators equipped to focus on the cancer problem in their research careers; (2) providing education spanning the chemical-biological interface; (3) emphasizing links between basic science and the clinical problems of human cancer. The Training Program achieved some notable successes during its initial funding cycle that will be carried forth into the current funding cycle, including: (1) markedly increasing the enrollment of under-represented minority trainees; (2) graduating postdoctoral trainees who have gone on to faculty positions at academic institutions; (3) providing biological training for two postdoctoral chemists and training in chemistry for two predoctoral Cancer Biology trainees.