North Carolina A&T University-Wake Forest Cancer Center partnership (2 of 2)

描述(由申请人提供)：这份P20提案是维克森林大学综合癌症中心(WFUCCC)和北卡罗来纳农业技术大学(NC A&T)生物和化学系之间的研究和教育合作伙伴关系。该伙伴关系的目标是：(1)促进WFUCCC与NC A&T之间的癌症研究合作，特别是专注于癌症差异的研究，并通过与WFUCCC的合作和提供的指导，促进NC A&T少数族裔癌症研究教师的职业发展；(2)为了培养少数族裔本科生和硕士研究生在北卡罗来纳大学获得癌症生物学博士学位的兴趣。为了实现第一个目标，P20将为两个合作研究项目提供试点资金：(1)WFUCCC的Suzy Torti博士和Yong Chen博士将指导并与NCA&T化学助理教授Marion Franks博士合作进行一个项目，合成和评估作为前列腺癌化学预防药物的新型亚甲基化合物；(2)WFUCCC脑瘤中心主任Waldemar Debinski博士将指导NC A&T生物学助理教授Patrick Martin博士开展一个项目，了解转录因子Fra1在胶质母细胞瘤细胞流动性和治疗耐药性中的作用。为了实现第二个目标：(1)被选中的北卡罗来纳大学RISE、MARC和BRAND项目的本科生将参加由WFUCCC教员指导的湿实验室、计算生物学或健康差距拓展项目；(2)每个试点项目团队将选择至少一名北卡罗来纳农工大学硕士学位学生参与该项目。这些学生将被允许作为WFUCCC癌症生物学博士生继续参与这些项目；(3)WFUCCC和NC A&T教职员工将合作开发癌症基因组学和癌症动物模型的教学模块，用于NC A&T目前正在进行的课程工作。在P20结束时，预计：(1)Franks和Martin博士及其合作者将联合撰写RO1；(2)WFUCCC和NC A&T将编写一份R25桥梁申请，以支持NC A&T学生进入WFUU癌症生物学博士项目。

DESCRIPTION (provided by applicant): This P20 proposal presents a research and educational partnership between the Wake Forest University Comprehensive Cancer Center (WFUCCC) and the Departments of Biology and Chemistry of North Carolina Agricultural and Technical University (NC A&T). The objectives of the partnership are: (1) to foster cancer research collaborations between WFUCCC and NC A&T, especially research focused on cancer disparities and to facilitate the career development of minority cancer research faculty at NC A&T through collaborations with and mentoring provided by the WFUCCC; (2) to foster interest in obtaining a PhD in cancer biology among minority undergraduate and Master's degree students at NC A&T. To achieve the first objective, the P20 will provide pilot funds for two collaborative research projects: (1) Drs. Suzy Torti and Yong Chen of the WFUCCC will mentor and collaborate with Dr. Marion Franks, Assistant Professor of Chemistry at NC A&T, on a project to synthesize and evaluate novel benzylidenes as prostate cancer chemopreventive agents; (2) Dr. Waldemar Debinski, Director of the Brain Tumor Center of the WFUCCC, will mentor and collaborate with Dr. Patrick Martin, Assistant Professor of Biology at NC A&T on a project to understand the role of transcription factor Fra1 in glioblastoma cell mobility and resistance to therapeutics. To achieve the second objective: (1) Selected RISE, MARC, and BLEND program undergraduates at NC A&T will participate in wet laboratory, computational biology, or health disparity outreach projects mentored by WFUCCC faculty; (2) Each pilot project team will select at least one NC A&T Master's degree student to ; participate in the project. The students will be offered the option of continued participation in the projects as PhD students in Cancer Biology at WFU; (3) WFUCCC and NC A&T faculty will collaborate to develop didactic teaching modules in cancer genomics and animal models of cancer for currently ongoing coursework at NC A&T. By the conclusion of the P20 it is expected that: (1) Drs. Franks and Martin and their WFUCCC collaborators will be writing joint RO1s; (2) The WFUCCC and NC A&T will be writing an R25 bridge application to support enrollment of NC A&T students in the PhD program in Cancer Biology at WFU.