Building Biomedical Research Center at VSU

描述(由申请人提供)：NCMHD-RIMI计划的目标是通过向培养大量生物医学科学少数族裔学生和教师的机构提供资源来减少健康差距。基于这些目标，弗吉尼亚州立大学(VSU)提出了一项RIMI计划，旨在增强和加强VSU进行基础生物医学研究的基础设施和能力，以解决并最终消除健康差距。该计划将发展基础设施，以加强VSU的研究，向学生和教职员工灌输创新的教育经验，让教职员工和学生接触尖端生物医学研究，并通过合作加强少数族裔教职员工/学生对生物医学研究的参与。 VSU-RIMI计划的目标是：i)在VSU建立生物医学研究的研究能力，ii)促进教职员工和学生参与生物医学和行为研究，iii)加强生物医学科学和健康差距方面的学术计划。VSU-RIMI计划提出了四大核心：行政核心、共享资源/基础设施核心、教师发展研究核心和学术提升核心。这四个核心提出了具体目标，包括NCMHD-RIMI计划的所有主要目标。在学院的研究核心中，我们提出了三个涉及健康差距和人类健康问题的研究项目。这些子项目是：1)寻找遗传性人类疾病-糖尿病的易感成分的比较基因组学策略，2)早老素突变和淀粉样蛋白在阿尔茨海默病发展中相互作用的研究，以及3)宿主对内部寄生虫感染的易感性或抵抗力和免疫反应的比较和功能基因组学方法。 我们提议的RIMI项目将包括一个由项目主管、布朗博士、一名项目协调员、一名研究助理和三名教职员工担任联合绩效指标的人员团队。管理团队将由一个机构咨询委员会提供建议，整个RIMI项目将对外部咨询委员会进行监督。该项目包括弗吉尼亚大学、路易斯安那州立大学、犹他州立大学和威廉与玛丽学院作为合作机构，这些机构都是研究密集型机构。RIMI计划将由一名外部顾问每年进行评估，并将评估拟议的和实际取得的成果，并向外部咨询委员会和RIMI项目主任提供报告。通过拟议的计划良好的RIMI计划，在项目期的五年内，我们预计可以通过发表论文的数量、资助的提案、进入研究生院的学生数量和参与生物医学研究的教师总数来衡量研究效率翻一番。

DESCRIPTION (provided by applicant): The aims of the NCMHD-RIMI program are to reduce health disparities by providing resources to institutions that prepare significant number of minority students and faculty in biomedical sciences. Based on these aims, Virginia State University (VSU) proposes a RIMI program that is aimed to augment and strengthen the infrastructure and capacity of VSU to conduct basic biomedical research which will address and ultimately eliminate health disparities. The program will develop infrastructure to enhance research at VSU, infuse innovative educational experiences to students and faculty, expose faculty and students to cutting-edge biomedical research, and through collaborations enhance minority faculty/student participation in biomedical research. VSU-RIMI program objectives are: I) to build research capacity for biomedical research at VSU, ii) to promote the participation of faculty and students in biomedical and behavioral research, and iii) to enhance academic programs in biomedical sciences and health disparities. VSU-RIMI program proposes four major cores: administrative core, shared resources/infrastructure core, faculty developmental research core, and academic enhancement core. These four cores with the proposed specific aims consist of all major aims which are goals of NCMHD-RIMI program. Within the faculty research core, we propose three research projects which deal with health disparities and human health issues. These subprojects are: 1) Comparative Genomics Strategies for Finding Susceptibility Components for Inherited Human Disease-Diabetes, 2) Study of interaction between presenilin mutations and amyloid protein in development of Alzheimer's disease, and 3) A Comparative and Functional Genomic Approach to Host Susceptibility or Resistance and Immune Responses to Internal Parasite Infections. Our proposed RIMI program will include a team of personnel that will be headed by project director, Dr. Brown, a program coordinator, a research associate and three faculty members serving as co-PIs. Management team will be advised by an institutional advisory committee and overall RIMI program will have an oversight of an external advisory committee. The program includes University of Virginia, Louisiana State University, Utah State University, and College of William and Mary as collaborating institutions which are research intensive institutions. The RIMI program will be evaluated annually by an external consultant and proposed and actual accomplishments will be evaluated and a report will be provided to the external advisory committee and the RIMI program director. With the proposed well-planned RIMI program, within the five year of the project period, we anticipate to double the research productivity which could be measured in the number of publications, funded proposals, number of students entering graduate school and total number of faculty participating in biomedical research.