Development and Use of rtfMRI for Self-control of Nicotine Craving

rtfMRI 的开发和使用用于自我控制尼古丁渴望

• 批准号: 8104244
• 负责人: Mark K Greenwald
• 金额: $ 55.09万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8104244
• 关键词: Accounting; Algorithms; Anterior; Area; Auditory area; Biological; Brain; Brain region; Cerebrovascular Circulation; Characteristics; Chronic Disease; Cigarette; Classification; Clinical; Cocaine; Computer software; Data; Data Set; Development; Disease; Drug Addiction; Elements; Evaluation; Feedback; Functional Magnetic Resonance Imaging; Future; General Population; Goals; Individual; Individual Differences; Instruction; Insula of Reil; Investigation; Knowledge; Lead; Learning; Location; Machine Learning; Measurement; Measures; Methodology; Methods; Modeling; Nicotine; Nicotine Dependence; Opiates; Outcome; Pain; Patients; Pattern; Performance; Pharmaceutical Preparations; Placebo Control; Placebo Effect; Placebos; Prevalence; Procedures; Process; Public Health; Real-Time Systems; Recurrence; Regression Analysis; Reproducibility; Sampling; Self-control as a personality trait; Signal Transduction; Solutions; Spin Labels; Substance Use Disorder; Substance of Abuse; Techniques; Testing; Therapeutic; Time; Training; Training Technics; Treatment outcome; Variant; addiction; alternative treatment; base; blood flow measurement; blood oxygen level dependent; cingulate cortex; craving; expectation; experience; hemodynamics; heuristics; improved; interest; mathematical model; multidisciplinary; neurofeedback; nicotine craving; public health relevance; reconstruction; relating to nervous system; research study; response; substance abuse treatment; vector; visual feedback; visual motor; volunteer

DESCRIPTION (provided by applicant): This application aims to study the application of functional magnetic resonance imaging in real time (rtfMRI) as an operant training feedback mechanism for treating substance use disorders. Recent data suggest that individuals can reduce activity in some brain regions (e.g. anterior cingulate cortex, anterior insula, auditory cortex when they are presented with information about activation in that brain region. Experimental and clinical pain have been reduced with rtfMRI signal feedback from the rostral anterior cingulate in a manner proportional to reductions in the blood oxygenation level dependent (BOLD) signal from that region. These regions overlap with those involved in the effects of substances of abuse and the development of substance use disorders (SUDs). The initial information opens the possibility of applying neurofeedback to improve treatment outcomes in patient samples. The present application seeks to expand the investigation of these processes and validate their applicability to substance dependent volunteers. In initial studies we will examine the capacity of nicotine dependent volunteers to reduce their craving for cigarettes. This substance was selected for its high retention rates and prevalence and public health burden in the general population, but it is expected that future studies would explore other forms of addiction (e.g. cocaine, opiates). Our multidisciplinary team proposes to advance current knowledge in this area by: (1) using data not from a single brain region, but from networks involved in nicotine craving and dependence, thereby accounting for inter- individual differences in brain regional activation patterns during nicotine craving; (2) developing a quantifiable method by using arterial spin labeling (ASL); and (3) determining the influence of individual expectations on these processes (e.g. assessing the degree to which these effects are attributable to placebo-related responding). The developmental and experimental elements of this application will lead to new avenues for treatment that would be readily generalizable to other forms of drug addiction besides nicotine, and potentially impacting on the outcomes of the substantial numbers of individuals seeking substance abuse treatment. PUBLIC HEALTH RELEVANCE: The development of new methodology for the treatment of patients with substance use disorders would represent a significant advance in the therapeutics of these disorders. The studies proposed offer a new treatment alternative for these otherwise highly recurrent and chronic illnesses.

描述（由申请人提供）：本申请旨在实时研究功能磁共振成像（RTFMRI）作为治疗药物使用障碍的操作培训反馈机制。最近的数据表明，当个体可以减少某些大脑区域的活动（例如，在向该大脑区域的激活中提供有关激活的信息时，前扣带回皮层，前岛，前岛，听觉皮层。实验和临床疼痛已通过ROSTRAL信号反馈减少了rostral前部的信号反馈。涉及滥用的物质和物质使用障碍的影响（SUD）。它的高保留率，普遍性和公共卫生负担在普通人群中，但预计未来的研究将探索其他形式的成瘾形式（例如，可卡因，阿片类药物）。渴望（2）使用动脉自旋标记（ASL）开发可量化的方法；寻求药物滥用治疗的个人的结果。 公共卫生相关性：开发用于治疗药物使用障碍患者的新方法将代表这些疾病的治疗疗法的重大进步。拟议的研究为这些原本高度复发和慢性病提供了一种新的治疗方法。