Development and Use of rtfMRI for Self-control of Nicotine Craving

rtfMRI 的开发和使用用于自我控制尼古丁渴望

• 批准号: 8087596
• 负责人: Mark K Greenwald
• 金额: $ 56.27万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8087596
• 关键词: Accounting; Algorithms; Anterior; Area; Auditory area; Biological; Brain; Brain region; Cerebrovascular Circulation; Characteristics; Chronic Disease; Cigarette; Classification; Clinical; Cocaine; Computer software; Data; Data Set; Dependence; Development; Disease; Drug Addiction; Elements; Evaluation; Feedback; Functional Magnetic Resonance Imaging; Future; General Population; Goals; Individual; Individual Differences; Instruction; Insula of Reil; Investigation; Knowledge; Lead; Learning; Location; Machine Learning; Measurement; Measures; Methodology; Methods; Modeling; Nicotine; Opiates; Outcome; Pain; Patients; Pattern; Performance; Pharmaceutical Preparations; Placebo Control; Placebo Effect; Placebos; Prevalence; Procedures; Process; Public Health; Real-Time Systems; Recurrence; Regression Analysis; Reproducibility; Sampling; Self-control as a personality trait; Signal Transduction; Solutions; Spin Labels; Substance Use Disorder; Substance of Abuse; Techniques; Testing; Therapeutic; Time; Training; Training Technics; Treatment outcome; Variant; addiction; alternative treatment; base; blood flow measurement; blood oxygen level dependent; cingulate cortex; craving; expectation; experience; hemodynamics; heuristics; improved; interest; mathematical model; multidisciplinary; neurofeedback; nicotine craving; public health relevance; reconstruction; relating to nervous system; research study; response; substance abuse treatment; vector; visual feedback; visual motor; volunteer

DESCRIPTION (provided by applicant): This application aims to study the application of functional magnetic resonance imaging in real time (rtfMRI) as an operant training feedback mechanism for treating substance use disorders. Recent data suggest that individuals can reduce activity in some brain regions (e.g. anterior cingulate cortex, anterior insula, auditory cortex when they are presented with information about activation in that brain region. Experimental and clinical pain have been reduced with rtfMRI signal feedback from the rostral anterior cingulate in a manner proportional to reductions in the blood oxygenation level dependent (BOLD) signal from that region. These regions overlap with those involved in the effects of substances of abuse and the development of substance use disorders (SUDs). The initial information opens the possibility of applying neurofeedback to improve treatment outcomes in patient samples. The present application seeks to expand the investigation of these processes and validate their applicability to substance dependent volunteers. In initial studies we will examine the capacity of nicotine dependent volunteers to reduce their craving for cigarettes. This substance was selected for its high retention rates and prevalence and public health burden in the general population, but it is expected that future studies would explore other forms of addiction (e.g. cocaine, opiates). Our multidisciplinary team proposes to advance current knowledge in this area by: (1) using data not from a single brain region, but from networks involved in nicotine craving and dependence, thereby accounting for inter- individual differences in brain regional activation patterns during nicotine craving; (2) developing a quantifiable method by using arterial spin labeling (ASL); and (3) determining the influence of individual expectations on these processes (e.g. assessing the degree to which these effects are attributable to placebo-related responding). The developmental and experimental elements of this application will lead to new avenues for treatment that would be readily generalizable to other forms of drug addiction besides nicotine, and potentially impacting on the outcomes of the substantial numbers of individuals seeking substance abuse treatment. PUBLIC HEALTH RELEVANCE: The development of new methodology for the treatment of patients with substance use disorders would represent a significant advance in the therapeutics of these disorders. The studies proposed offer a new treatment alternative for these otherwise highly recurrent and chronic illnesses.

描述（由申请人提供）：本申请旨在研究实时功能磁共振成像（rtfMRI）作为治疗物质使用障碍的操作训练反馈机制的应用。最近的数据表明，当个体收到有关大脑区域激活的信息时，可以减少某些大脑区域（例如前扣带皮层、前岛叶、听觉皮层）的活动。通过来自前扣带皮层的 rtfMRI 信号反馈，实验和临床疼痛已减少，其方式与该区域血氧水平依赖 (BOLD) 信号的减少成比例。这些区域重叠 那些涉及滥用药物的影响和药物使用障碍（SUD）发展的人。初步信息开启了应用神经反馈改善患者样本治疗结果的可能性。本申请旨在扩大对这些过程的研究并验证它们对物质依赖志愿者的适用性。在初步研究中，我们将检查尼古丁依赖志愿者减少对香烟的渴望的能力。该物质被选为 其高保留率和流行率以及普通人群的公共健康负担，但预计未来的研究将探索其他形式的成瘾（例如可卡因、阿片类药物）。我们的多学科团队建议通过以下方式推进该领域的当前知识：（1）使用不是来自单个大脑区域的数据，而是来自涉及尼古丁渴望和依赖的网络的数据，从而解释尼古丁期间大脑区域激活模式的个体间差异 渴望； （2）利用动脉自旋标记（ASL）开发一种可量化的方法； (3)确定个人期望对这些过程的影响（例如评估这些影响在多大程度上归因于安慰剂相关的反应）。该应用的开发和实验要素将带来新的治疗途径，这些途径很容易推广到尼古丁以外的其他形式的药物成瘾，并可能影响 大量寻求药物滥用治疗的人的结果。 公共卫生相关性：治疗物质使用障碍患者的新方法的开发将代表这些疾病治疗的重大进步。拟议的研究为这些高度复发的慢性疾病提供了一种新的治疗替代方案。