CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 波士顿大学提议建立一个临床和翻译科学研究所，即BU-Bridge研究所，该研究所将整合、连接和扩展我们现有的研究和大学项目，从而为下一代临床和翻译研究人员提供学术和智力之家。该研究所将围绕五个部门组成：1)转化科学孵化器；2)信息学；3)临床研究增强；4)社区参与；5)研究教育和培训。这五个部门是专门为支持从实验室或床边开始的想法的双向开发和转化而设计的，这些想法可以无缝地来回移动，从而产生新的相关工具，以改善卫生保健和提供服务。BU-Bridge将实现五个具体目标：1)协调现有BU科学家之间的现有合作，并确定有可能发展为多学科翻译计划的新合作，并促进BU创造知识产权和翻译科学思想商业化的“一站式购物”计划；2)通过试点拨款网络，支持进一步开发和创建新的翻译计划和核心。3)提供新的和现有的临床和转译研究计划，扩大和丰富基于BU-Bridge的机构支持菜单，包括改进的、用户友好的医疗信息学系统(仓库)，将研究从我们的GCRC扩展到社区人群，为伦理、监管问题、研究设计、分析和卫生干预措施的实施提供综合方法4)为临床医生和临床和基础科学家之间的双向思想交流提供渠道，以更充分地让社区参与研究过程，包括设定调查优先事项、设计研究、确保进行伦理研究并根据研究结果实施最佳实践；5)作为培训下一代研究人员的中心，使用适当的工具将基础科学转化为临床研究。新的学院是跨大学的实体，取代了传统的系和学院。它包括多个关键的大学项目，包括国家新兴传染病实验室、弗雷明翰心脏研究、波士顿大学技术开发商业化组合办公室、生物医学工程和生物信息学系、萨金特联合卫生专业学院、波士顿医疗网络、波士顿医学中心和退伍军人医院，这些项目支持大学范围内建立翻译研究之家的承诺。CTSA奖将提供资源，通过利用现有优势创造一个环境，将新想法、教师、学员和大学项目联系起来，加快医学科学的创新。BU-Bridge的使命与公共卫生相关，因为它将促进地方和国家社区成员可用的医疗实践的发展。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Boston University proposes to create a Clinical and Translational Science Institute, the BU-BRIDGE Institute, that will integrate, connect and expand our current research and university programs and, thereby, provide an academic and intellectual home for the next generation of clinical and translational investigators. The Institute will be organized around five Divisions: 1} Translational Science Incubator; 2) Informatics; 3) Clinical Research Enhancements; 4) Community Engagements; and 5) Research Education and Training. These five divisions are specifically designed to support the bi-directional development and translation of ideas that begin in the laboratory or bedside move seamlessly back and forth to result in new relevant tools to improve health, health care and delivery. The BU-BRIDGE will accomplish five specific aims: 1) Coordinate existing and identify new collaborations among existing BU scientists with the potential to develop into multidisciplinary translational programs, and facilitate the BU "one stop shopping" program for creating intellectual property and commercialization of translational scientific ideas; 2) Support the further development of existing and the creation of new translational programs and cores through a network of pilot grants. 3) Provide new and existing Clinical and Translational research programs with an expanded and enriched menu of BU-BRIDGE-based institutional support, including an improved, user friendly medical informatics syslem (warehouse), expansion of research from our GCRC into community populations, provide an integrated approach to ethics, regulatory issues, study design, analysis and implementation of health interventions 4) Provide the conduit for bi- directional flow of ideas between clinicians and clinical and basic scientists to more fully engage the community in the research process including setting priorities for investigation, designing studies, ensuring ethical research conduct and implementing best practices based on study results; 5) Serve as the Center for training the next generation of investigators with the proper tools to translate basic science into clinical research. The new institute is cross University entity that supercedes traditional departments and schools. It encorporates multiple key university programs including the National Emerging Infectious Diseases Laboratory, Framingham Heart Study, Boston University Office of Technology Development Commercialization portfolio, Departments of Biomedical Engineering and Bioinformatics, Sargent College of Allied Heath Professionals, the Boston Health Net, Boston Medical Center and VA Hospitals that support the university wide commitment for a home for translational research. The CTSA award will provide the resources to transform the institute by leveraging existing strengths to create an environment that will link new ideas, faculty, trainees and university programs to speed innovations in medical science. The mission of the BU-BRIDGE is relevant to the public health as it will enhance the development of healthcare practices available to members of the local and national communities.