CTSA INFRASTRUCTURE FOR AIDS RESEARCH

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 我们已经建立了圣地亚哥临床和转化研究所（圣地亚哥CTRI），其中心位于加州大学圣地亚哥分校（UCSD）。该区域中心包括两所大学（加州大学圣地亚哥分校和圣地亚哥州立大学），4个生物医学研究所（索尔克研究所，伯纳姆研究所，J.克雷格文特尔研究所，和拉霍亚研究所，过敏和免疫学），和3个学术医院（加州大学圣地亚哥分校医疗中心，VA医院和拉迪儿童医院），一个社区卫生服务（帕洛玛Pomerado健康）和2个专业资源-圣地亚哥超级计算机中心和加州研究所，电信和信息技术。CTSA计划包括3个健康科学专业学校（医学，药学，护理），9个临床研究博士课程和一个高级临床研究硕士课程。该方案的目标是：1）为临床和转化科学学科提供学术家园; 2）建立一个综合的教育管道，以培训和支持临床和转化科学家; 3）开发一个强大的临床研究基础设施，以综合研究取代孤岛; 4）提高生物信息学能力，利用独特的UCSD资源; 5）开发新技术，以改善生物标志物和成像等研究; 6）与研究机构和行业建立转化研究联盟; 7）与社区医生和公众建立社区联盟，将科学发现转化为最佳实践，增加对医疗保健差异的研究，并让公众参与生物医学科学。CTSA计划将提供资源，以发展临床和转化研究的学科。通过圣地亚哥CTRI，培养下一代临床和转化科学家的教育管道将得到加强。一个新的K12计划，一个扩大的K30计划，以及新的博士研究生课程在临床研究中的整合突出了拟议的教育计划。CTRI将通过协调不同的项目来改变临床和转化科学的教育，提供从高中到博士前学生的广泛教育，并为博士后研究员和教师提供培训。该研究所还将通过从最初规划到数据分析和共享提供指导和支持，改变临床研究的开展方式。新架构将促进新技术的发展，以促进临床研究，并为进行临床研究所需的服务和资源提供支持。我们将特别强调几个优势领域，如成像，生物标志物，社区推广，以及基础科学发现到临床科学的翻译。相关性（参见说明）：圣地亚哥临床转化研究所将通过从初始规划到数据分析和共享提供指导和支持来改变临床研究。它将提供一个教育管道，以培养下一代临床和转化科学家，并让社区参与制定该组织的方向和优先事项。该研究所将促进新技术的开发，促进临床研究，并为开展临床研究和改善健康所需的服务提供支持。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have established the San Diego Clinical and Translational Research Institute (San Diego CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center contains two universities (UCSD and San Diego State University), 4 biomedical research institutes (Salk Inst., Burnham Inst., J. Craig Venter Inst., and La Jolla Inst, for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA Hospital and Rady Children's Hospital), one community health sen/ice (Palomar Pomerado Health) and 2 specialized resources~the San Diego Supercomputer Center and the California Inst, for Telecommunications and Information Technology. The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, Nursing), nine clinical research PhD programs, and a Masters program in Advanced Clinical Studies. The program goals are to: 1) Provide an academic home for the discipline of clinical and translational science; 2) Establish an integrated educational pipeline to train and support clinical and translational scientists; 3) Develop a robust clinical research infrastructure that replaces silos with integrated research; 4) Enhance bioinformatics capabilities that leverage unique UCSD resources; 5) Develop novel technologies to improve research such as biomarker and imaging; 6) Form a Translational Research Alliance with research institutes and industry; 7) Form a Community Alliance with community physicians and the general public to translate scientific discoveries into best practices, increase research into health care disparities, and involve the general public in biomedical science. The CTSA program will provide the resources to develop the discipline of clinical and translational research. Through the San Diego CTRI, the educational pipeline to train the next generation of clinical and translational scientists will be enhanced. A new K12 program, an expanded K30 program, and the integration of new PhD graduate programs in clinical research highlight the proposed educational plan. The CTRI will transform education in clinical and translational science by coordinating disparate programs, providing breadth of education from high school through pre-doctoral students and providing training to post-doctoral fellows and faculty. The Institute will also transform the conduct of clinical research by providing guidance and support from initial planning through data analysis and sharing. The new structure will foster development of novel technologies to facilitate clinical research and provide support for the services and resources necessary to conduct clinical investigation. We will place special emphasis on several areas of strength such as imaging, biomarkers, community outreach, and the translation of basic science discoveries to clinical science. RELEVANCE (See instructions): The San Diego Clinical Translational Research Institute will transform the clinical research by providing guidance and support from initial planning through data analysis and sharing. It will provide an educational pipeline to train the next generation of clinical and translational scientists and involve the community in setting the direction and priorities of the organization. The Institute will foster development of novel technologies that facilitate clinical research, and provide support for the services needed to conduct clinical investigation and improve health.