CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8364987
• 负责人: Allan R. Brasier
• 金额: $ 12.13万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364987
• 关键词: Acquired Immunodeficiency Syndrome; Award; Clinical Sciences; Research; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application is for an ICTSA to be established at the University of Texas Medical Branch at Galveston (UTMB). Our rationale is that UTMB brings depth to the CTSA consortium, because: we are the only academic health center with both an NIAID-funded Regional Center for Excellence in Biodefense and a National Biocontainment Laboratory; we are the only center with two NIH-funded translationally oriented proteomics centers in biomarker research; we have developed translational research programs with three national laboratories (the Galveston and Sandia National Laboratories and NASA); we have trained more underrepresented minority MDs than any non-historically Black institution in the US; we have the only approved PhD-awarding Clinical Science Training program in a public university in Texas; and we have the largest telemedicine operation in the world. In response to Hurricane Ike, we have established a richer outpatient clinical research network in South East Texas. Our ICTSA are to: 1. Facilitate translational research as a rigorous discipline; 2. Develop translational research training programs at all levels in the graduate continuum; 3. Effectively conduct and bridge step 1 translational research (Tl) to steps 2 (T2) and -3 (T3); and 4. Interface productively with the national CTSA Consortium. To accomplish these goals, we have organized our ICTSA into 12 "Key Resources" ~ combinations of university core laboratories and intellectual resources, integrated by a single point of investigator/trainee contact. This structure will make us more rapidly responsive to the needs of our investigators and trainees. In this application, our Key Resources are assembled to support the translational goals of exemplar multidisciplinary translational teams (MTTs), generally organized around our successful NIH- funded interdisciplinary research centers. Three overlying principles will guide our ICTSA's operations, to: 1. Employ proactive mechanisms in identifying new team-oriented research opportunities; 2. Prioritize trainee involvement in a team-based culture; and 3. Integrate systems biological approaches into translational research. UTMB's senior leadership is providing significant new institutional resources, including establishing the Institute for Translational Sciences (ITS), our new home for translational research; new commitments of pilot grant support; administrative support; and support for a significant expansion of bioinformatics faculty. The ITS Director reports directly to UTMB's Provost, who is responsible for integration of research and education university-wide. We are thus well-positioned to achieve our goals, significantly transform clinical and translational research at UTMB, and contribute to the national CTSA Consortium. RELEVANCE (See instructions): The ICTSA will allow our researchers to more quickly and effectively translate basic science discoveries into improvements in human health. In particular this award will allow us to build teams of researchers with diverse skills who can work effectively towards a health outcome-related goal. In this way the ICTSA will break down communication, technology and regulatory barriers and transform how our university conducts patient-oriented research.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 本申请是关于在德克萨斯大学加尔维斯顿分校(UTMB)建立ICTSA的申请。我们的理由是UTMB为CTSA财团带来了深度，因为：我们是唯一同时拥有NIAID资助的区域生物防御卓越中心和国家生物遏制实验室的学术卫生中心；我们是唯一拥有NIH资助的生物标记物研究方面两个面向翻译的蛋白质组学中心的中心；我们与三个国家实验室(加尔维斯顿和桑迪亚国家实验室和NASA)共同开发了翻译研究计划；我们培养的少数族裔医生比美国任何非黑人机构都多；我们拥有得克萨斯州唯一获得批准的授予博士学位的临床科学培训项目；我们拥有世界上最大的远程医疗业务。为了应对飓风艾克，我们在德克萨斯州东南部建立了一个更丰富的门诊临床研究网络。我们的ICTSA是为了：1.促进翻译研究作为一门严格的学科；2.在研究生阶段的所有级别发展翻译研究培训计划；3.有效地开展和衔接第一步翻译研究(TL)与第二步(T2)和第三步(T3)；以及4.与全国CTSA联盟进行富有成效的接口。为了实现这些目标，我们将我们的ICTSA组织成12个“关键资源”--大学核心实验室和智力资源的组合，通过单一的研究人员/受训人员联系人进行整合。这一结构将使我们对我们的调查人员和受训人员的需求作出更迅速的反应。在这一应用中，我们的关键资源是为了支持模范多学科翻译团队(MTT)的翻译目标，这些团队通常围绕我们成功的NIH资助的跨学科研究中心组织。三个首要原则将指导我们ICTSA的运作：1.采用积极主动的机制来确定新的以团队为导向的研究机会；2.优先考虑学员参与以团队为基础的文化；以及3.将系统生物学方法整合到翻译研究中。UTMB的高级领导层正在提供重要的新机构资源，包括建立翻译科学研究所(ITS)，这是我们翻译研究的新基地；新的试点赠款支持承诺；行政支持；以及支持显著扩大生物信息学教师队伍。ITS主任直接向UTMB教务长报告，教务长负责整个大学范围内的研究和教育整合。因此，我们处于有利地位，能够实现我们的目标，显著改变UTMB的临床和翻译研究，并为国家CTSA联盟做出贡献。相关性(参见说明)：ICTSA将允许我们的研究人员更快、更有效地将基础科学发现转化为人类健康的改善。特别是，这一奖项将使我们能够建立具有不同技能的研究人员团队，他们能够有效地实现与健康结果有关的目标。通过这种方式，ICTSA将打破沟通、技术和监管障碍，并改变我们大学开展以患者为导向的研究的方式。