UTMB CLINICAL AND TRANSLATIONAL SCIENCE AWARD

UTMB 临床和转化科学奖

• 批准号: 8364984
• 负责人: Allan R. Brasier
• 金额: $ 540.75万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364984
• 关键词: Award; Clinical Sciences; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application is for an ICTSA to be established at the University of Texas Medical Branch at Galveston (UTMB). Our rationale is that UTMB brings depth to the CTSA consortium, because: we are the only academic health center with both an NIAID-funded Regional Center for Excellence in Biodefense and a National Biocontainment Laboratory; we are the only center with two NIH-funded translationally oriented proteomics centers in biomarker research; we have developed translational research programs with three national laboratories (the Galveston and Sandia National Laboratories and NASA); we have trained more underrepresented minority MDs than any non-historically Black institution in the US; we have the only approved PhD-awarding Clinical Science Training program in a public university in Texas; and we have the largest telemedicine operation in the world. In response to Hurricane Ike, we have established a richer outpatient clinical research network in South East Texas. Our ICTSA are to: 1. Facilitate translational research as a rigorous discipline; 2. Develop translational research training programs at all levels in the graduate continuum; 3. Effectively conduct and bridge step 1 translational research (Tl) to steps 2 (T2) and -3 (T3); and 4. Interface productively with the national CTSA Consortium. To accomplish these goals, we have organized our ICTSA into 12 "Key Resources" ~ combinations of university core laboratories and intellectual resources, integrated by a single point of investigator/trainee contact. This structure will make us more rapidly responsive to the needs of our investigators and trainees. In this application, our Key Resources are assembled to support the translational goals of exemplar multidisciplinary translational teams (MTTs), generally organized around our successful NIH- funded interdisciplinary research centers. Three overlying principles will guide our ICTSA's operations, to: 1. Employ proactive mechanisms in identifying new team-oriented research opportunities; 2. Prioritize trainee involvement in a team-based culture; and 3. Integrate systems biological approaches into translational research. UTMB's senior leadership is providing significant new institutional resources, including establishing the Institute for Translational Sciences (ITS), our new home for translational research; new commitments of pilot grant support; administrative support; and support for a significant expansion of bioinformatics faculty. The ITS Director reports directly to UTMB's Provost, who is responsible for integration of research and education university-wide. We are thus well-positioned to achieve our goals, significantly transform clinical and translational research at UTMB, and contribute to the national CTSA Consortium. RELEVANCE (See instructions): The ICTSA will allow our researchers to more quickly and effectively translate basic science discoveries into improvements in human health. In particular this award will allow us to build teams of researchers with diverse skills who can work effectively towards a health outcome-related goal. In this way the ICTSA will break down communication, technology and regulatory barriers and transform how our university conducts patient-oriented research.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 该申请是为了在德克萨斯大学医学分公司（UTMB）建立ICTSA。我们的理由是，UTMB为CTSA财团带来了深度，因为：我们是唯一一个拥有NIAID资助的生物融合区域卓越区域中心和国家生物培养实验室的学术保健中心；我们是唯一一个在生物标志物研究中具有两个NIH资助的以翻译为导向的蛋白质组学中心的中心。我们已经开发了三个国家实验室（加尔维斯顿和桑迪亚国家实验室和NASA）的转化研究计划；与美国任何非历史上的黑人机构相比，我们培训了代表性不足的少数族裔MD。我们拥有德克萨斯州一所公立大学唯一获得批准的博士学位临床科学培训计划；而且我们拥有世界上最大的远程医疗操作。为了回应艾克飓风，我们在德克萨斯州东南部建立了一个更丰富的门诊临床研究网络。我们的ICTSA是：1。促进翻译研究作为一门严格的学科； 2。在毕业生连续体的各个级别制定翻译研究培训计划； 3。有效地进行和桥接步骤1转化研究（TL）到步骤2（T2）和-3（T3）；和4。与国家CTSA财团有效的界面。为了实现这些目标，我们将ICTSA组织成12个“关键资源”〜大学核心实验室和智力资源的组合，由一个调查员/受训者联系的单点集成。这种结构将使我们对调查人员和学员的需求更快地响应。在此应用程序中，我们的关键资源是为了支持典范多学科翻译团队（MTTS）的翻译目标，该目标通常围绕我们成功的NIH资助的跨学科研究中心组织。三项横跨原则将指导我们的ICTSA的运作：1。采用积极主动的机制来确定新的面向团队的研究机会； 2。优先考虑学员参与基于团队的文化；和3。将系统生物学方法整合到转化研究中。 UTMB的高级领导层正在提供大量的新机构资源，包括建立转化科学研究所（ITS），这是我们的转化研究新家；试点赠款支持的新承诺；行政支持；并支持大量扩大生物信息学教师。它的董事直接向UTMB的教务长报告，后者负责整合大学范围内的研究和教育。因此，我们的位置良好以实现我们的目标，显着改变UTMB的临床和转化研究，并为国家CTSA联盟做出贡献。相关性（请参阅说明）：ICTSA将使我们的研究人员更快有效地将基础科学发现转化为人类健康的改进。特别是，该奖项将使我们能够建立具有多种技能的研究人员团队，他们可以有效地实现与健康结果相关的目标。这样，ICTSA将分解沟通，技术和监管障碍，并改变我们的大学以患者为导向的研究。