CTSA Supplement

CTSA 补充

基本信息

  • 批准号:
    9250940
  • 负责人:
  • 金额:
    $ 11.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-18 至 2020-03-31
  • 项目状态:
    已结题

项目摘要

Contact PD/PI: Brasier, Allan R. The CTSA at the University of Texas Medical Branch (UTMB) is located within the Institute for Translational Science (ITS), one of three free-standing UTMB institutes, established in 2007. In its role as the home for clinical and translational research, the ITS provides primary tenure-earning faculty appointments to 7 early- career translational scientists. Over the past 5½ years, we have transformed UTMB's research culture, growing from an institution that solely valued individual laboratory-oriented research to one that embraces multidisciplinary translational team (MTT) approaches to addressing significant health problems. We have developed novel educational curricula, significant clinical research programs in special populations with multi- site clinical trials (CTs), and provided leadership in the Texas Regional CTSA consortium (TRCC) and nationally. The mission of the UTMB CTSA hub is to support the health goals of the nation by generating, testing and disseminating integrative team science, education and best practices through stakeholder involvement at all stages. Managed by a continuous improvement model using an Innovation Scorecard, the UTMB CTSA will address four specific aims, to: 1) Train a diverse workforce in the authentic skills needed to advance all phases of translational research. We have used the team environment as an educational framework to support the training of diverse learning communities. Our innovation, entrepreneurship, and team leadership curricula will be used to instill focused, career stage-appropriate competencies in our trainees. We have led in sharing and disseminating innovative educational content in entrepreneurship and team science throughout the consortium. 2). Engage stakeholders across all phases of translational research and CTs. We will extend our substantial bidirectional interactions with stakeholders from the community, patient advocacy groups, healthcare providers and our Health System to assess health needs, set CTSA priorities and disseminate competencies. 3). Integrate quality systems through all types of translational research, including CTs in special populations. We have provided leadership to a university-wide plan for sustainable support for high-quality CTs through the Office of Clinical Research, supported by an experienced director, an interoperable Clinical Trial Management System and staff to provide streamlined support for all phases of CT start-up, quality assurance monitoring, study management and GCP training. 4). Advance the conduct of translational research through MTT-based innovation. The UTMB CTSA hub is unique in the national consortium in its systematic application of a hybrid industry-academic MTT model, and have developed an evidence base on the formation, evaluation, impact and trajectories of successful MTTs. We will stimulate MTT innovation by promoting team development, leadership development by a unique Leadership Development Academy, and advancement of therapeutics and devices into Phase I/II CTs in our “Innovations in Molecular Therapeutics and Devices” Optional Module. Project Summary/Abstract Page 308 Contact PD/PI: Brasier, Allan R. Narrative The UTMB CTSA hub will support bidirectional translational research, moving discoveries from the bench to the bedside, by training a capable workforce using our unique multidisciplinary translational teams and innovative educational programs that build real-world skills. Our hub will serve to foster high-quality clinical research, develop best practices in team-based translations, participate in inter-institutional data-sharing, and function as an efficient site for multi-site clinical trials in understudied populations. In this manner, the UTMB CTSA hub will be an important contributor to achieving the goals of the national consortium.
联系PD/PI: Brasier, Allan R。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Allan R. Brasier其他文献

The NF-κB regulatory network
  • DOI:
    10.1385/ct:6:2:111
  • 发表时间:
    2006-06-01
  • 期刊:
  • 影响因子:
    3.700
  • 作者:
    Allan R. Brasier
  • 通讯作者:
    Allan R. Brasier
11: BRD4-MK2 SIGNALING: TARGET FOR CROHN'S DISEASE-ASSOCIATED FIBROSIS.
  • DOI:
    10.1016/s0016-5085(22)60011-8
  • 发表时间:
    2022-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Marina Chulkina;Steven B. McAninch;Yi Li;Walter Koltun;Gregory S. Yochum;Bing Tian;Jia Zhou;Ellen J. Beswick;Allan R. Brasier;Iryna V. Pinchuk
  • 通讯作者:
    Iryna V. Pinchuk
33 NOVEL SMALL MOLECULE BRD4 INHIBITORS SUPPRESS COLONIC INFLAMMATION IN MOUSE MODELS OF INFLAMMATORY BOWEL DISEASE
  • DOI:
    10.1016/s0016-5085(21)00770-8
  • 发表时间:
    2021-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Zhiqing Liu;Gabriela Uribe;Yi Li;Pingyuan Wang;Haiying Chen;Yingzi Cong;Allan R. Brasier;Iryna V. Pinchuk;Jia Zhou;Bing Tian
  • 通讯作者:
    Bing Tian
Transcriptional regulation of angiotensinogen gene expression.
血管紧张素原基因表达的转录调控。
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Allan R. Brasier;Youqi Han;C. T. Sherman
  • 通讯作者:
    C. T. Sherman
Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
  • 作者:
    Leopoldo Aguilera-Aguirre;Wenging Hao;Lang Pan;Xiaoxue Li;Alfredo Saavedra-Molina;Attila Bacsi;Zsolt Radak;Sanjiv Sur;Allan R. Brasier;Xueqing Ba;Istvan Boldogh
  • 通讯作者:
    Istvan Boldogh

Allan R. Brasier的其他文献

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{{ truncateString('Allan R. Brasier', 18)}}的其他基金

Epigenetic Control of Mucosal IRF1/IFN-III Antiviral Response by Enhancer-like Promoter and its Coding lncRNA
增强子样启动子及其编码lncRNA对粘膜IRF1/IFN-III抗病毒反应的表观遗传控制
  • 批准号:
    10373575
  • 财政年份:
    2021
  • 资助金额:
    $ 11.63万
  • 项目类别:
Epigenetic Control of Mucosal IRF1/IFN-III Antiviral Response by Enhancer-like Promoter and its Coding lncRNA
增强子样启动子及其编码lncRNA对粘膜IRF1/IFN-III抗病毒反应的表观遗传控制
  • 批准号:
    10495267
  • 财政年份:
    2021
  • 资助金额:
    $ 11.63万
  • 项目类别:
Epigenetic Mechanism Reprogramming Mucosal Anti-viral Immunity in Allergic Asthma
过敏性哮喘粘膜抗病毒免疫的表观遗传机制重编程
  • 批准号:
    10553704
  • 财政年份:
    2019
  • 资助金额:
    $ 11.63万
  • 项目类别:
Epigenetic Mechanism Reprogramming Mucosal Anti-viral Immunity in Allergic Asthma
过敏性哮喘粘膜抗病毒免疫的表观遗传机制重编程
  • 批准号:
    10371977
  • 财政年份:
    2019
  • 资助金额:
    $ 11.63万
  • 项目类别:
UTMB Clinical and Translational Science Award
UTMB 临床和转化科学奖
  • 批准号:
    9128790
  • 财政年份:
    2015
  • 资助金额:
    $ 11.63万
  • 项目类别:
Transcriptional Elongation in NF-kB Mediated Inflammation
NF-kB 介导的炎症中的转录延伸
  • 批准号:
    8710493
  • 财政年份:
    2013
  • 资助金额:
    $ 11.63万
  • 项目类别:
UTMB CLINICAL AND TRANSLATIONAL SCIENCE AWARD
UTMB 临床和转化科学奖
  • 批准号:
    8364984
  • 财政年份:
    2011
  • 资助金额:
    $ 11.63万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8364988
  • 财政年份:
    2011
  • 资助金额:
    $ 11.63万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8364987
  • 财政年份:
    2011
  • 资助金额:
    $ 11.63万
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8364986
  • 财政年份:
    2011
  • 资助金额:
    $ 11.63万
  • 项目类别:

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