CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

CTSA 临床试验基础设施

• 批准号: 8365145
• 负责人: JOSEPH G VERBALIS
• 金额: $ 510.85万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365145
• 关键词: Clinical Sciences; Clinical Trials; Research Infrastructure; Translational Research; Universities

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a primary partnership of Georgetown University (GU) and Howard University (HU), with 3 affiliated hospital systems and research institutes: MedStar Health and Research Institute (MSH/MRI), Oak Ridge National Laboratory (ORNL), and the Washington, DC Veteran's Affairs Medical Center (WVAMC). This application is a resubmission of a revised previous application from 2008. The specific aims of GHUCCTS are: 1) To speed improvements in human health by stimulating innovative, multidisciplinary, and cross-institutional research among the GHUCCTS investigators; 2) To support the careers of clinical and translational investigators through a wide variety of didactic educational programs coupled with focused mentorship; and 3) To enhance clinical and translational research on underserved populations, both in the Washington DC region and nationally, prominently including minorities, the aged, and the disabled. To accomplish these aims, we will integrate our existing NCRR-funded programs, including two existing MOI-funded GCRCs at GU and HU and our successful multi-institutional K30 program, with a new and innovative hospital, practice- based, laboratory-based, and community-based research infrastructure for clinical and translational science. The new capabilities that we will build as part of GHUCCTS include a coordinated multi-institutional biomedical informatics infrastructure, an expanded clinical research operation that will create new community-based clinical research units, a new community engagement resource component to support and enhance community-based research, expanded resources in regulatory knowledge and support that will be intimately integrated with ethics, and new funded research projects in the development of novel translational methodologies in collaboration with the supercomputing and systems genetics translational capabilities of ORNL. The integration of these clinical and translational resources across the GHUCCTS institutions will be accompanied by a strong research education, training, and career development program that will train a new generation of researchers, including a new Clinical and Translational Scholars K12 program and a new Masters degree program in clinical and translational science. Our innovative approach to collaboration and multi-disciplinary research involving multiple major research-intensive institutions of our region, in collaboration with the national CTSA network, will help our institutions and our community in the Washington, DC area benefit from the generation and application of new discoveries in clinical and translational science.

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 乔治城-霍华德大学临床和转化科学中心（GHUCCTS）是乔治城大学（GU）和霍华德大学（HU）的主要合作伙伴，拥有3个附属医院系统和研究机构：MedStar健康和研究所（MSH/MRI），橡树岭国家实验室（ORNL）和华盛顿退伍军人事务医疗中心（WVAMC）。本申请是对2008年修订后的先前申请的重新提交。GHUCCTS的具体目标是：1）通过刺激GHUCCTS研究者之间的创新，多学科和跨机构研究来加速人类健康的改善; 2）通过各种各样的教学教育计划以及重点指导来支持临床和翻译研究者的职业生涯; 3）加强对华盛顿地区和全国服务不足人群的临床和转化研究，主要包括少数民族、老年人和残疾人。为了实现这些目标，我们将整合我们现有的NCRR资助的计划，包括两个现有的MOI资助的GCRC在GU和HU和我们成功的多机构K30计划，与一个新的和创新的医院，实践为基础的，以实验室为基础的，以社区为基础的临床和转化科学的研究基础设施。作为GHUCCTS的一部分，我们将建立的新能力包括协调的多机构生物医学信息学基础设施，扩大的临床研究操作，将创建新的基于社区的临床研究单位，新的社区参与资源组成部分，以支持和加强基于社区的研究，扩大监管知识和支持的资源，将与伦理学紧密结合，以及新资助的研究项目，与ORNL的超级计算和系统遗传学翻译能力合作开发新的翻译方法。这些临床和翻译资源在GHUCCTS机构的整合将伴随着强大的研究教育，培训和职业发展计划，将培养新一代的研究人员，包括新的临床和翻译学者K12计划和新的临床和翻译科学硕士学位课程。我们创新的合作和多学科研究方法涉及本地区多个主要研究密集型机构，与国家CTSA网络合作，将帮助我们在华盛顿特区的机构和社区受益于临床和转化科学新发现的产生和应用。