GEORGETOWN-HOWARD UNIVERSITIES CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (GH

乔治敦-霍华德大学临床与转化科学中心 (GH

• 批准号: 8173900
• 负责人: JOSEPH G VERBALIS
• 金额: $ 177.42万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173900
• 关键词: Clinical; Translational Research; Universities

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a primary partnership of Georgetown University (GU) and Howard University (HU), with 3 affiliated hospital systems and research institutes: MedStar Health and Research Institute (MSH/MRI), Oak Ridge National Laboratory (ORNL), and the Washington, DC Veteran's Affairs Medical Center (WVAMC). This application is a resubmission of a revised previous application from 2008. The specific aims of GHUCCTS are: 1) To speed improvements in human health by stimulating innovative, multidisciplinary, and cross-institutional research among the GHUCCTS investigators; 2) To support the careers of clinical and translational investigators through a wide variety of didactic educational programs coupled with focused mentorship; and 3) To enhance clinical and translational research on underserved populations, both in the Washington DC region and nationally, prominently including minorities, the aged, and the disabled. To accomplish these aims, we will integrate our existing NCRR-funded programs, including two existing MOI-funded GCRCs at GU and HU and our successful multi-institutional K30 program, with a new and innovative hospital, practice- based, laboratory-based, and community-based research infrastructure for clinical and translational science. The new capabilities that we will build as part of GHUCCTS include a coordinated multi-institutional biomedical informatics infrastructure, an expanded clinical research operation that will create new community-based clinical research units, a new community engagement resource component to support and enhance community-based research, expanded resources in regulatory knowledge and support that will be intimately integrated with ethics, and new funded research projects in the development of novel translational methodologies in collaboration with the supercomputing and systems genetics translational capabilities of ORNL. The integration of these clinical and translational resources across the GHUCCTS institutions will be accompanied by a strong research education, training, and career development program that will train a new generation of researchers, including a new Clinical and Translational Scholars K12 program and a new Masters degree program in clinical and translational science. Our innovative approach to collaboration and multi-disciplinary research involving multiple major research-intensive institutions of our region, in collaboration with the national CTSA network, will help our institutions and our community in the Washington, DC area benefit from the generation and application of new discoveries in clinical and translational science.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 乔治敦-霍华德大学临床和翻译科学中心(GHUCCTS)是乔治敦大学(GU)和霍华德大学(HU)的主要合作伙伴，拥有3个附属医院系统和研究机构：MedStar健康与研究院(MSH/MRI)、橡树岭国家实验室(ORNL)和华盛顿特区退伍军人事务医疗中心(WVAMC)。这份申请是对2008年修订后的前一份申请的重新提交。GHUCCTS的具体目标是：1)通过鼓励GHUCCTS研究人员进行创新的、多学科的和跨机构的研究，加快人类健康的改善；2)通过各种教学计划和重点指导，支持临床和翻译研究人员的职业生涯；以及3)加强对华盛顿特区地区和全国范围内未得到充分服务的人群(主要包括少数族裔、老年人和残疾人)的临床和翻译研究。为了实现这些目标，我们将整合我们现有的NCRR资助的项目，包括州立大学和HU现有的两个MOI资助的GCRC，以及我们成功的多机构K30项目，以及一个新的、创新的医院、实践、实验室和社区基础研究基础设施，用于临床和转化科学。作为GHUCCTS的一部分，我们将建设的新能力包括协调的多机构生物医学信息学基础设施、将创建新的基于社区的临床研究单位的扩大的临床研究业务、支持和增强基于社区的研究的新的社区参与资源部分、将与伦理紧密结合的监管知识和支持方面的扩展资源、以及与ORNL的超级计算和系统遗传学翻译能力合作开发新型翻译方法的新资助研究项目。GHUCCTS机构的这些临床和翻译资源的整合将伴随着强大的研究教育、培训和职业发展计划，该计划将培训新一代研究人员，包括新的临床和翻译学者K12计划和新的临床和翻译科学硕士学位计划。我们以创新的方式开展协作和多学科研究，涉及本地区多个主要研究密集型机构，与国家CTSA网络合作，将帮助我们的机构和华盛顿特区地区的社区从临床和转化科学新发现的产生和应用中受益。