Management and Retrieval of Multidisciplinary HIV Research Data

描述（由申请人提供）：标题：多学科HIV研究数据的管理和检索摘要我们建议建立一个关系数据库和生物信息学工具包，为微生物病原体及其感染的人类宿主的临床、实验室和遗传数据的获取、保留和评估提供软件基础设施。为了发现致病机制和预防感染和疾病的方法，以及解决紧迫的公共卫生问题，我们将开发工具包，重点是艾滋病毒作为一种典型的病毒性传染病。为了确保互操作性和最大效用，该工具包将与著名的研究人员合作开发，这些研究人员共同负责当今艾滋病毒领域的大部分前沿数据采集和分析。数据库和配套工具将动态链接所有可用数据，以允许大量合作科学家轻松跟踪所有受试者和标本的临床历史、当前状态、实验结果和分析。它将作为一个完全可搜索的资源，用于最终形成数据的所有工作，并作为综合数据分析的来源。 公共卫生相关性：我们建议扩大和完善一个新的数据库和生物信息学工具包，其中将包括一个关系数据库和工具包，它们共同构成一个软件基础设施，用于获取、保留和评价来自微生物病原体及其受感染人类宿主的临床、实验室和遗传数据。为了发现疾病的致病机制和预防感染和疾病的方法，以及解决紧迫的公共卫生问题，我们将把重点放在艾滋病毒作为一种典型的病毒性传染病。

DESCRIPTION (provided by applicant): Title: Management and Retrieval of Multidisciplinary HIV Research Data Abstract We propose to build a relational database and bioinformatics toolkit to provide a software infrastructure for the acquisition, retention and evaluation of clinical, laboratory and genetic data derived from microbial pathogens and their infected human hosts. With the goal of discovering mechanisms of disease causation and means of preventing infection and disease, as well as addressing an urgent public health problem, we will develop the toolkit with a focus on HIV as a prototypical viral infectious disease. To assure interoperability and maximal util- ity, the toolkit will be developed in collaboration with prominent investigators who are together responsible for much of the leading edge data acquisition and analysis in the HIV field today. The database and accompany- ing tools will dynamically link all available data to allow a large array of collaborating scientists to easily track the clinical histories, current status, experimental results and analyses for all subjects and specimens. It will serve as a fully searchable resource for all work leading to the finalized data and as a source for integrated data analysis. PUBLIC HEALTH RELEVANCE: We propose to expand and refine a new database and bioinformatics toolkit that will include a relational database and toolkit that together comprise a software infrastructure to be used for the acquisition, retention and evaluation of clinical, laboratory and genetic data derived from microbial pathogens and their infected human hosts. With the goal of discovering mechanisms of disease causation and means of preventing infection and disease, as well as addressing an urgent public health problem, we will focus on HIV as a prototypical viral infectious disease.