Program Administration and Data IVIanagement

在海洋和平方案内提出的研究是复杂的和多学科的，它们涉及多个领域。 研究者和研究中心、人类参与者队列以及临床和研究测定。至关重要的是，它们还涉及最先进的调查，以促进对原发性HIV-1感染的进一步了解，并提供推进最终阻止HIV-1感染和疾病进展的概念和方法所需的重要信息。这些复杂研究之间的逻辑支持、协调和协同作用对整个研究计划的成功至关重要。因此，Muliins博士和他的团队在Collier博士的协助下，与其他项目和核心的合作研究人员和工作人员合作，将投入大量的时间和精力。 除了标准的行政和财政管理职能外，该核心将负责汇集来自不同学科的有才华的科学家和临床医生，以开展多方面和独特的协同研究，并持续关注对疾病管理和疫苗开发最关键的原发性艾滋病毒感染方面。该核心还将负责开发一个数据库，以协调实验室数据采集和管理（目标3），与临床核心B和生物统计学核心D紧密联系。数据库和分析工具的设计和应用将通过与所有SeaPIP调查人员的互动来推动，并根据他们的具体数据采集，检索和分析需求量身定制。因此，核心的这个方面也将与其他项目和核心密切、持续地交互，以获取、访问和分析数据。为进一步加强调查人员的协同作用，将在数据库中建立一个简要报告功能，以提示感兴趣的调查人员访问每个项目和核心项目的详细进展情况，并提示新的或扩大调查的想法。

The studies proposed within the SeaPIP are complex and multidisciplinary, and they involve multiple investigators and sites, cohorts of human participants and clinical and investigational assays. Critically, they also involve state-of-the-art investigations to facilitate additional understanding of primary HIV-1 infection and to provide important information needed to advance concepts and methods for ultimately blocking the establishment of HIV-1 infection and disease progression. Logistical support, coordination, and synergism between such complex studies are crucial to the success of the overall research program. Hence, a significant amount of time and effort of Dr. Muliins and his team, assisted by Dr. Collier and working with collaborating investigators and staff in other Projects and Cores, will be devoted to this endeavor. In addition to standard administrative and fiscal management functions, this core will be responsible for bringing together talented scientists and clinicians from diverse disciplines in order to develop multifaceted and uniquely synergistic studies with continual focus on aspects of primary HIV infection most critical to disease management and vaccine development. This core will also be responsible for the development of a database to coordinate laboratory data acquisition and management (Aim 3), interfacing strongly with Clinical Core B and Biostatistics Core D. Design and application of the database and analytical tools will be driven through interaction with all SeaPIP investigators and tailored to their specific data acquisition, retrieval and analysis needs. Hence, this aspect of the core will also interact closely and continuously with each of the other projects and cores to acquire, access and analyze data. To further enhance investigator synergy, a summary-reporting feature will be built into the database to prompt interested investigators to access detailed progress within each Project and Core and prompt ideas for new or expanded investigations.