Program Administration and Data IVIanagement

在SeaPIP内提出的研究是复杂的和多学科的，它们涉及多个 研究人员和地点、人类参与者队列以及临床和调查分析。至关重要的是，它们还涉及最先进的调查，以促进对艾滋病毒-1原发感染的进一步了解，并提供所需的重要信息，以推动最终阻止艾滋病毒-1感染和疾病进展的概念和方法。这些复杂研究之间的后勤支持、协调和协同作用对整个研究计划的成功至关重要。因此，穆林斯博士和他的团队将在科利尔博士的协助下，在其他项目和核心中与合作的调查人员和工作人员合作，投入大量时间和精力进行这项工作。 除了标准的行政和财政管理职能外，该核心还将负责将来自不同学科的有才华的科学家和临床医生聚集在一起，以开发多方面和独特的协同研究，继续侧重于对疾病管理和疫苗开发最关键的主要艾滋病毒感染方面。该核心还将负责开发一个数据库，以协调实验室数据采集和管理(目标3)，与临床核心B和生物统计核心D紧密对接。数据库和分析工具的设计和应用将通过与所有SeaPIP调查人员的互动推动，并根据其特定的数据采集、检索和分析需求进行调整。因此，核心的这一方面也将与每个其他项目和核心密切和持续地互动，以获取、访问和分析数据。为进一步加强调查员的协同作用，将在数据库中加入摘要报告功能，以促使感兴趣的调查人员查阅每个项目和核心项目的详细进展情况，并提示新的或扩大的调查的想法。

The studies proposed within the SeaPIP are complex and multidisciplinary, and they involve multiple investigators and sites, cohorts of human participants and clinical and investigational assays. Critically, they also involve state-of-the-art investigations to facilitate additional understanding of primary HIV-1 infection and to provide important information needed to advance concepts and methods for ultimately blocking the establishment of HIV-1 infection and disease progression. Logistical support, coordination, and synergism between such complex studies are crucial to the success of the overall research program. Hence, a significant amount of time and effort of Dr. Muliins and his team, assisted by Dr. Collier and working with collaborating investigators and staff in other Projects and Cores, will be devoted to this endeavor. In addition to standard administrative and fiscal management functions, this core will be responsible for bringing together talented scientists and clinicians from diverse disciplines in order to develop multifaceted and uniquely synergistic studies with continual focus on aspects of primary HIV infection most critical to disease management and vaccine development. This core will also be responsible for the development of a database to coordinate laboratory data acquisition and management (Aim 3), interfacing strongly with Clinical Core B and Biostatistics Core D. Design and application of the database and analytical tools will be driven through interaction with all SeaPIP investigators and tailored to their specific data acquisition, retrieval and analysis needs. Hence, this aspect of the core will also interact closely and continuously with each of the other projects and cores to acquire, access and analyze data. To further enhance investigator synergy, a summary-reporting feature will be built into the database to prompt interested investigators to access detailed progress within each Project and Core and prompt ideas for new or expanded investigations.