2010 and 2012 Protein Folding Dynamics Gordon Research Conference and Graduate Re

描述(由申请人提供)：本提案的目的是申请资金支持第五届和第六届戈登蛋白质折叠动力学研究会议(GRC)和随之而来的蛋白质折叠动力学研究生研究研讨会(GRS)，这是一个针对研究生和博士后的研讨会，讨论蛋白质折叠的方法和模型。2010年会议将于2010年1月9日至10日(GRS)和1月10日(GRC)在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。下一次会议定于2012年1月举行。会议的广泛和长期目标是将实验和理论结合在一起；它是实验生物物理学专家和理论和计算机模拟专家之间讨论的论坛。这次会议将成为一个讨论基本问题的论坛，从多肽能量学和动力学；到伴侣辅助折叠以及蛋白质错误折叠与疾病之间的关系。蛋白质折叠动力学研究生研究研讨会的具体目的是为研究生和博士后科学家提供一个场所，让他们i)发展当前技术、理论和模型的背景，为蛋白质折叠动力学GRC做准备，ii)分享他们关于蛋白质折叠方法和技术的知识，以及iii)彼此见面并讨论他们自己的研究。这一应用的意义在于，年轻和发展中的科学家参与和纳入蛋白质折叠动力学研究生研究研讨会代表了我们愿景的一个关键目标，即为这一充满活力的多学科研究领域提供科学家，他们在实验蛋白质折叠方法以及为解释该领域实验提供基础的模型和理论方面具有广泛的基础。 公共卫生相关性：该应用程序的健康相关性是多方面的。目前该领域研究的讨论将直接应用于我们对许多错误折叠疾病的理解和治疗，以及由于蛋白平衡丧失而导致的许多病理和衰老问题。在更广泛的意义上，会议和研讨会将对对人类基因组变异的机械性理解产生影响，因为基因组中的大多数非同义变异会导致蛋白质动力学和能量学的微妙变化。

DESCRIPTION (provided by applicant): The purpose of this proposal is to request funding to support the 5th and 6th Gordon Research Conference (GRC) on Protein Folding Dynamics and the accompanying Graduate Research Seminar (GRS) in Protein Folding Dynamics, which is a workshop for graduate students and post docs addressing the methods and models of protein folding. The 2010 meetings will take place at the Ventura Beach Marriott, Ventura, California from January 9-10 (GRS) and January 10-15 (GRC), 2010. The subsequent meeting will be scheduled for January 2012. The broad and long term goal of the conference is to bring together experiment and theory; it is a forum for discussion between experts in experimental biophysics and experts in theory and computer simulation. The conference will serve as a forum to discuss fundamental problems from polypeptide energetics and dynamics; to chaperone assisted folding and the relationship between protein misfolding and disease. The specific aims of the Graduate Research Seminar in Protein Folding Dynamics is to serve as a venue for graduate students and postdoctoral scientists to i) develop background on current techniques, theories and models in preparation for the GRC in Protein Folding Dynamics, ii) share their knowledge of protein folding methodologies and techniques and iii) meet each other and discuss their own research. The significance of this application is that the Graduate Research Seminar in Protein Folding Dynamics involvement and inclusion of young and developing scientists represents a key objective in our vision to provide this vibrant multi-disciplinary research area with scientists who are broadly based in both experimental protein folding methodologies and the models and theories that provide a basis for the interpretation of experiment in this field. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is multifaceted. The discussions of current research in the field will directly apply to our understanding and treatment of the many misfolding diseases and the many pathologies and problems of aging that result from a loss of proteostasis. In a broader sense, the conference and workshop will have an impact on a mechanistic understanding to the variation in the human genome as most of the non-synonymous variation in the genome result in subtle changes in protein dynamics and energetics.