2010 and 2012 Protein Folding Dynamics Gordon Research Conference and Graduate Re

描述（由申请人提供）：本提案的目的是申请资助，以支持第五和第六届蛋白质折叠动力学戈登研究会议（GRC）和随之而来的蛋白质折叠动力学研究生研究研讨会（GRS），这是一个针对蛋白质折叠方法和模型的研究生和博士后的研讨会。2010年会议将于2010年1月9日至10日（GRS）和1月10日至15日（GRC）在加州文图拉的文图拉海滩万豪酒店举行。下一次会议定于2012年1月举行。会议的广泛和长期目标是把实验和理论结合起来；它是实验生物物理学专家与理论和计算机模拟专家之间讨论的论坛。会议将作为一个论坛，讨论多肽能量学和动力学的基本问题；目的：探讨蛋白伴蛋白辅助折叠及其与疾病的关系。蛋白质折叠动力学研究生研究研讨会的具体目的是为研究生和博士后科学家提供一个场所，i)为蛋白质折叠动力学GRC的准备提供当前技术，理论和模型的背景，ii)分享他们对蛋白质折叠方法和技术的知识，iii)见面并讨论他们自己的研究。这项申请的意义在于，蛋白质折叠动力学研究生研究研讨会的参与和包括年轻和发展中的科学家代表了我们愿景中的一个关键目标，即为这个充满活力的多学科研究领域提供广泛基于实验蛋白质折叠方法和模型和理论的科学家，这些模型和理论为该领域的实验解释提供了基础。

DESCRIPTION (provided by applicant): The purpose of this proposal is to request funding to support the 5th and 6th Gordon Research Conference (GRC) on Protein Folding Dynamics and the accompanying Graduate Research Seminar (GRS) in Protein Folding Dynamics, which is a workshop for graduate students and post docs addressing the methods and models of protein folding. The 2010 meetings will take place at the Ventura Beach Marriott, Ventura, California from January 9-10 (GRS) and January 10-15 (GRC), 2010. The subsequent meeting will be scheduled for January 2012. The broad and long term goal of the conference is to bring together experiment and theory; it is a forum for discussion between experts in experimental biophysics and experts in theory and computer simulation. The conference will serve as a forum to discuss fundamental problems from polypeptide energetics and dynamics; to chaperone assisted folding and the relationship between protein misfolding and disease. The specific aims of the Graduate Research Seminar in Protein Folding Dynamics is to serve as a venue for graduate students and postdoctoral scientists to i) develop background on current techniques, theories and models in preparation for the GRC in Protein Folding Dynamics, ii) share their knowledge of protein folding methodologies and techniques and iii) meet each other and discuss their own research. The significance of this application is that the Graduate Research Seminar in Protein Folding Dynamics involvement and inclusion of young and developing scientists represents a key objective in our vision to provide this vibrant multi-disciplinary research area with scientists who are broadly based in both experimental protein folding methodologies and the models and theories that provide a basis for the interpretation of experiment in this field. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is multifaceted. The discussions of current research in the field will directly apply to our understanding and treatment of the many misfolding diseases and the many pathologies and problems of aging that result from a loss of proteostasis. In a broader sense, the conference and workshop will have an impact on a mechanistic understanding to the variation in the human genome as most of the non-synonymous variation in the genome result in subtle changes in protein dynamics and energetics.