Phosphorylation and G Protein Signaling Networks Gordon Conferences

描述（由申请人提供）：自1970年以来，关于磷酸化和G蛋白信号网络的年度戈登研究会议（GRC），以前称为“第二信使和蛋白质磷酸化”，一直是展示信号转导研究新发现的主要场所。本提案要求为2009年、2010年和2011年举行的会议提供部分资金支持。从一开始就发起并参加会议的研究人员是建立细胞信号研究领域的关键领导者，其中许多人因其贡献而获得诺贝尔奖。本GRC主要关注激素、神经递质、生长因子以及炎症和感觉刺激作用下的信号网络。经典的主题开始并仍然包括蛋白质磷酸化和G蛋白依赖的信号。然而，会议还包括新的信号通路，新机制，细胞和生理功能的讨论。这些知识具有根本性和临床重要性，因为这些途径的故障会导致影响全世界数百万人的健康问题，并且针对相同的途径是当前大部分药物治疗的基础。会议旨在促进这一重要且快速发展的研究领域的持续发展。它还促进参与者之间的多学科思维和互动，强调分享新颖的实验方法。2005年，新英格兰大学成为本次会议的新址，并提供了一个理想的乡村和残疾人无障碍场所，以促进与会者之间的开放互动。2009年会议将于6月7日星期日晚上至6月12日星期四晚上举行。由Brian Kobilka主讲的G蛋白偶联受体（GPCR）的结构和功能将为会议奠定基础。由30多位受邀演讲者组成的杰出小组将讨论生化、结构、细胞生物学、基因组学、生理学和临床方法，这些方法共同提供了细胞信号传导机制及其与人类疾病和潜在治疗干预的关系的前沿领域。8个不同的会议，包括一名讨论主持人和3-5名演讲者，将重点关注GPCR的调节，GPCR的G蛋白独立信号传导，G蛋白调节蛋白，信号蛋白的亚细胞靶向，下游效应物和信号网络，GPCR促进的信号传导进入ras调节网络，G蛋白信号传导的结构基础，以及药物发现。联合主席将从申请者中选出135名参与者，其中包括工业界和学术界的代表、资深科学家、博士后和研究生。将作出特别努力，通过直接邮寄方式招募少数民族参与者和工业科学家。所有参与者将被鼓励在每天下午举行的两个小时的会议上展示海报。会议为年轻的研究人员提供了一个重要的论坛，以观察基础科学探究、发现和在人类疾病有效干预措施的最终设计中的应用之间的联系。为了给年轻科学家提供接触和经验，将选择8-10篇摘要进行口头报告。

DESCRIPTION (provided by applicant): The annual Gordon Research Conference (GRC) on Phosphorylation and G Protein Signaling Networks, formerly known as "Second Messengers and Protein Phosphorylation", has been a premier venue for presentation of new discoveries in signal transduction research since 1970. This proposal requests partial funding for support of the meetings to be held in 2009, 2010, and 2011. Investigators who initiated and attended the meeting from its inception are key leaders who established the field of cell signaling research, including many who received Nobel Prizes for their contributions. This GRC focuses on signaling networks underlying the action of hormones, neurotransmitters, and growth factors, as well as inflammatory and sensory stimuli. The classic themes began with and still include protein phosphorylation and G protein- dependent signaling. However, the meeting also incorporates discussions of new signaling pathways, novel mechanisms, and cellular and physiological functions. This knowledge is fundamentally and clinically important since malfunctions in these pathways contribute to health problems that affect millions worldwide and targeting the same pathways underlies much of current pharmacotherapy. The meeting is designed to foster continued growth of this important and rapidly evolving field of research. It also promotes multidisciplinary thinking and interaction among participants with an emphasis on sharing novel experimental approaches. The University of New England became the new site for this meeting in 2005, and provides an ideal rustic and handicapped-accessible venue to promote open interactions among attendees. The 2009 meeting will be held from Sunday evening, June 7 through Thursday evening, June 12. A keynote lecture by Brian Kobilka on the structure and function of G protein-coupled receptors (GPCR) will set the stage for the conference. An outstanding group of more than thirty invited speakers will discuss biochemical, structural, cell biological, genomic, physiological, and clinical approaches that together provide a front of the field view of mechanisms of cell signaling and their relationships to human disease and potential therapeutic interventions. Eight different sessions that include a discussion leader and 3-5 speakers will focus on regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, downstream effectors and signaling networks, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery. The co- chairs will select 135 participants from applicants including representatives from industry and academia, senior scientists, and postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and industrial scientists by direct mailing. All participants will be encouraged to present posters in two hour sessions held each afternoon. The conference provides an important forum for young investigators to observe the connection between fundamental scientific inquiry, discovery, and application in the ultimate design of efficacious interventions of human disease. To provide exposure and experience for junior scientists, 8-10 abstracts will be chosen for oral presentations. Public Health Relevance: Intricate cell signaling pathways provide the lines of communication from stimuli (hormones, transmitters released from nerves, molecules that regulate cell growth, and stimuli detected as light, taste, and smell) acting on the exterior of cells to changes in cell function. Understanding these signaling pathways at the molecular level is highly relevant to understanding human physiology in health and disease. The Gordon Research Conference on Phosphorylation and G Protein Signaling Networks brings together both established and beginning investigators in this field of research in an optimum format that fosters growth and depth of knowledge at the very forefront of current and anticipated drug therapies for diseases that affect millions worldwide.