Phosphorylation and G Protein Signaling Networks Gordon Conferences

磷酸化和 G 蛋白信号转导网络 Gordon Conferences

• 批准号: 8076873
• 负责人: John Tesmer
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076873
• 关键词: Academia; Affect; Biochemical; Biological; Cell physiology; Cells; Clinical; Communication; Disabled Persons; Disease; Fostering; Funding; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-substrate; GTP-Binding Proteins; Genomics; Growth; Growth Factor; Health; Hormones; Hour; Human; Industry; Inflammatory; Intervention; Knowledge; Light; Mails; Minority; Molecular; Nerve; Neurotransmitters; New England; Nobel Prize; Oral; Participant; Pathway interactions; Pharmacotherapy; Phosphorylation; Physiological; Physiology; Postdoctoral Fellow; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Scientist; Second Messenger Systems; Senior Scientist; Signal Pathway; Signal Transduction; Signaling Protein; Site; Smell Perception; Staging; Stimulus; Structure; Taste Perception; Therapeutic Intervention; Thinking; Universities; abstracting; base; cell growth; design; drug discovery; experience; graduate student; handicapping condition; human disease; intracellular protein transport; lectures; meetings; multidisciplinary; novel; posters; public health relevance; second messenger; sensory stimulus; symposium

DESCRIPTION (provided by applicant): The annual Gordon Research Conference (GRC) on Phosphorylation and G Protein Signaling Networks, formerly known as "Second Messengers and Protein Phosphorylation", has been a premier venue for presentation of new discoveries in signal transduction research since 1970. This proposal requests partial funding for support of the meetings to be held in 2009, 2010, and 2011. Investigators who initiated and attended the meeting from its inception are key leaders who established the field of cell signaling research, including many who received Nobel Prizes for their contributions. This GRC focuses on signaling networks underlying the action of hormones, neurotransmitters, and growth factors, as well as inflammatory and sensory stimuli. The classic themes began with and still include protein phosphorylation and G protein- dependent signaling. However, the meeting also incorporates discussions of new signaling pathways, novel mechanisms, and cellular and physiological functions. This knowledge is fundamentally and clinically important since malfunctions in these pathways contribute to health problems that affect millions worldwide and targeting the same pathways underlies much of current pharmacotherapy. The meeting is designed to foster continued growth of this important and rapidly evolving field of research. It also promotes multidisciplinary thinking and interaction among participants with an emphasis on sharing novel experimental approaches. The University of New England became the new site for this meeting in 2005, and provides an ideal rustic and handicapped-accessible venue to promote open interactions among attendees. The 2009 meeting will be held from Sunday evening, June 7 through Thursday evening, June 12. A keynote lecture by Brian Kobilka on the structure and function of G protein-coupled receptors (GPCR) will set the stage for the conference. An outstanding group of more than thirty invited speakers will discuss biochemical, structural, cell biological, genomic, physiological, and clinical approaches that together provide a front of the field view of mechanisms of cell signaling and their relationships to human disease and potential therapeutic interventions. Eight different sessions that include a discussion leader and 3-5 speakers will focus on regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, downstream effectors and signaling networks, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery. The co- chairs will select 135 participants from applicants including representatives from industry and academia, senior scientists, and postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and industrial scientists by direct mailing. All participants will be encouraged to present posters in two hour sessions held each afternoon. The conference provides an important forum for young investigators to observe the connection between fundamental scientific inquiry, discovery, and application in the ultimate design of efficacious interventions of human disease. To provide exposure and experience for junior scientists, 8-10 abstracts will be chosen for oral presentations. Public Health Relevance: Intricate cell signaling pathways provide the lines of communication from stimuli (hormones, transmitters released from nerves, molecules that regulate cell growth, and stimuli detected as light, taste, and smell) acting on the exterior of cells to changes in cell function. Understanding these signaling pathways at the molecular level is highly relevant to understanding human physiology in health and disease. The Gordon Research Conference on Phosphorylation and G Protein Signaling Networks brings together both established and beginning investigators in this field of research in an optimum format that fosters growth and depth of knowledge at the very forefront of current and anticipated drug therapies for diseases that affect millions worldwide.

描述（由申请人提供）：关于磷酸化和G蛋白信号网络的年度戈登研究会议（GRC），以前被称为“第二使者和蛋白质磷酸化”，一直是自1970年以来向信号转导研究中新发现的最佳场所，自1970年以来，该提案要求对派生的群体进行部分资金。 Inception是建立细胞信号研究领域的主要领导者，其中包括许多因其贡献而获得诺贝尔奖的人。该GRC着重于激素，神经递质和生长因子以及炎症和感觉刺激的作用的信号网络。经典主题始于，仍然包括蛋白质磷酸化和G蛋白依赖性信号传导。但是，会议还结合了关于新信号通路，新机制以及细胞和生理功能的讨论。这些知识从根本和临床上很重要，因为这些途径的故障导致了影响全球数百万的健康问题，并且针对相同的途径是当前许多药物治疗的基础。该会议旨在促进这一重要且迅速发展的研究领域的持续增长。它还促进了参与者之间的多学科思维和互动，重点是共享新型的实验方法。新英格兰大学成为2005年这次会议的新网站，并提供了一个理想的质朴和残障的场地，以促进与会者之间的公开互动。 2009年的会议将于6月7日星期日至6月12日（星期四）举行。布莱恩·科比卡（Brian Kobilka）关于G蛋白偶联受体（GPCR）的结构和功能的主题演讲将为会议奠定舞台。由三十多名受邀演讲者组成的杰出群体将讨论生化，结构，细胞生物学，基因组，生理和临床方法，共同提供了细胞信号传导机制及其与人类疾病和潜在治疗干预措施的机制的领域视图。 Eight different sessions that include a discussion leader and 3-5 speakers will focus on regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, downstream effectors and signaling networks, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery.这些合作社将从申请人中选出135名参与者，包括工业和学术界的代表，高级科学家以及博士后研究员和研究生。通过直接邮寄将做出特别的努力，以招募少数群体和工业科学家。将鼓励所有参与者在每天下午举行的两个小时会议上介绍海报。该会议为年轻研究人员提供了一个重要的论坛，以观察基本科学探究，发现和应用之间在最终设计人类疾病干预措施中的联系。为了为初级科学家提供曝光和经验，将选择8-10个摘要进行口头演示。 公共卫生相关性：复杂的细胞信号传导途径提供了刺激（激素，神经释放的发射器，调节细胞生长的分子的发射器以及作用在细胞外部的光，味道和气味的刺激）到细胞功能变化的刺激。了解分子水平的这些信号通路与了解健康和疾病中的人类生理学高度相关。戈登磷酸化和G蛋白信号网络的戈登研究会议以最佳格式将建立和开始研究人员汇集在一起​​，从而在当前和预期的药物疗法的最前沿培养知识和知识深度，用于影响全球数百万的疾病。