Phosphorylation and G Protein Signaling Networks Gordon Conferences

描述(由申请者提供)：一年一度的戈登研究会议(GRC)关于磷酸化和G蛋白信号网络，以前被称为“第二信使和蛋白质磷酸化”，自1970年以来一直是展示信号转导研究新发现的主要场所。该提案要求为2009年、2010年和2011年举行的会议提供部分资金。从会议一开始就发起和参加会议的研究人员是建立细胞信号研究领域的关键领导人，包括许多因贡献而获得诺贝尔奖的人。这一GRC侧重于激素、神经递质、生长因子以及炎症和感官刺激作用下的信号网络。经典的主题开始于并仍然包括蛋白质磷酸化和G蛋白依赖的信号转导。然而，会议还包括对新的信号通路、新的机制以及细胞和生理功能的讨论。这一知识从根本上和临床上都很重要，因为这些通路中的故障会导致影响全球数百万人的健康问题，而针对同样的通路是当前药物治疗的主要基础。这次会议的目的是促进这一重要和快速发展的研究领域的持续增长。它还促进参与者之间的多学科思考和互动，重点是分享新颖的实验方法。新英格兰大学于2005年成为本次会议的新会址，为促进与会者之间的开放互动提供了一个理想的乡村和残障人士无障碍场所。2009年会议将于6月7日周日晚至6月12日周四晚举行。Brian Kobilka将发表关于G蛋白偶联受体(GPCR)结构和功能的主旨演讲，为会议奠定基础。一个由30多名受邀演讲者组成的杰出小组将讨论生化、结构、细胞生物学、基因组、生理和临床方法，这些方法共同提供细胞信号机制及其与人类疾病的关系和潜在治疗干预的领域观点的前沿。八个不同的会议，包括一位讨论领袖和3-5位发言者，将集中讨论GPCR的调控，G蛋白非依赖于G蛋白的信号转导，G蛋白调节蛋白，信号蛋白的亚细胞靶向，下游效应器和信号网络，GPCR促进的信号进入RAS调节的网络，G蛋白信号的结构基础，以及药物发现。联席主席将从申请者中挑选135名参与者，包括来自工业界和学术界的代表、资深科学家、博士后研究员和研究生。将特别努力通过直接邮寄的方式招募少数族裔参与者和工业科学家。所有参与者将被鼓励在每天下午举行的两个小时的会议中展示海报。会议为年轻的研究人员提供了一个重要的论坛，以观察在人类疾病有效干预的最终设计中基础科学探索、发现和应用之间的联系。为了给初级科学家提供机会和经验，8-10篇摘要将被选作口头报告。 与公共健康相关：错综复杂的细胞信号通路提供了从作用于细胞外部的刺激(激素、神经释放的递质、调节细胞生长的分子，以及检测到的光、味道和气味等刺激)到细胞功能变化的通信线路。在分子水平上了解这些信号通路对于理解人类健康和疾病的生理学具有重要意义。戈登的磷酸化和G蛋白信号网络研究会议以最佳的形式汇聚了这一研究领域的知名和初学者，促进了当前和预期的疾病药物治疗的前沿知识的增长和深度，这些疾病影响着全球数百万人。

DESCRIPTION (provided by applicant): The annual Gordon Research Conference (GRC) on Phosphorylation and G Protein Signaling Networks, formerly known as "Second Messengers and Protein Phosphorylation", has been a premier venue for presentation of new discoveries in signal transduction research since 1970. This proposal requests partial funding for support of the meetings to be held in 2009, 2010, and 2011. Investigators who initiated and attended the meeting from its inception are key leaders who established the field of cell signaling research, including many who received Nobel Prizes for their contributions. This GRC focuses on signaling networks underlying the action of hormones, neurotransmitters, and growth factors, as well as inflammatory and sensory stimuli. The classic themes began with and still include protein phosphorylation and G protein- dependent signaling. However, the meeting also incorporates discussions of new signaling pathways, novel mechanisms, and cellular and physiological functions. This knowledge is fundamentally and clinically important since malfunctions in these pathways contribute to health problems that affect millions worldwide and targeting the same pathways underlies much of current pharmacotherapy. The meeting is designed to foster continued growth of this important and rapidly evolving field of research. It also promotes multidisciplinary thinking and interaction among participants with an emphasis on sharing novel experimental approaches. The University of New England became the new site for this meeting in 2005, and provides an ideal rustic and handicapped-accessible venue to promote open interactions among attendees. The 2009 meeting will be held from Sunday evening, June 7 through Thursday evening, June 12. A keynote lecture by Brian Kobilka on the structure and function of G protein-coupled receptors (GPCR) will set the stage for the conference. An outstanding group of more than thirty invited speakers will discuss biochemical, structural, cell biological, genomic, physiological, and clinical approaches that together provide a front of the field view of mechanisms of cell signaling and their relationships to human disease and potential therapeutic interventions. Eight different sessions that include a discussion leader and 3-5 speakers will focus on regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, downstream effectors and signaling networks, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery. The co- chairs will select 135 participants from applicants including representatives from industry and academia, senior scientists, and postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and industrial scientists by direct mailing. All participants will be encouraged to present posters in two hour sessions held each afternoon. The conference provides an important forum for young investigators to observe the connection between fundamental scientific inquiry, discovery, and application in the ultimate design of efficacious interventions of human disease. To provide exposure and experience for junior scientists, 8-10 abstracts will be chosen for oral presentations. Public Health Relevance: Intricate cell signaling pathways provide the lines of communication from stimuli (hormones, transmitters released from nerves, molecules that regulate cell growth, and stimuli detected as light, taste, and smell) acting on the exterior of cells to changes in cell function. Understanding these signaling pathways at the molecular level is highly relevant to understanding human physiology in health and disease. The Gordon Research Conference on Phosphorylation and G Protein Signaling Networks brings together both established and beginning investigators in this field of research in an optimum format that fosters growth and depth of knowledge at the very forefront of current and anticipated drug therapies for diseases that affect millions worldwide.