Affective Instability and Features of Borderline Personality in Adolescent Girls

描述(由申请人提供)：这个研究职业发展奖(K01)的目标是提供一个为期五年的职业发展和研究培训计划，使候选人能够就情感不稳定(AI)在女孩童年和青春期发展中的作用进行研究。BPD是一种复杂的、令人衰弱的疾病，与频繁的自杀行为、强烈和长期的痛苦以及高治疗利用率有关。BPD通常在青壮年首次诊断，女性的诊断不成比例。BPD有四个主要特征：AI、人际功能障碍、行为失控和认同感障碍。主要理论表明，人工智能在BPD的发展中起着主要作用，父母对情感的反应在缓冲或增加AI水平高的女孩的风险方面尤为重要。然而，关于BPD发生发展过程的病因机制的纵向研究很少。为了满足这一需要，培训和研究计划在纵向框架内纳入了行为和心理生理学方法，以调查人工智能在青春期女孩BPD其他特征发展中的作用。候选人将在Paul Pilkonis博士、共同导师Greg Siegle以及包括Rolf Loeber博士和Ronald Dahl博士在内的专家团队的指导下，进行与青春期女孩相关的发展研究方法方面的培训，使用生态瞬时评估(EMA)评估自然环境中的影响，以及情感的心理生理学。这项拟议的研究将利用EMA、心理生理学(瞳孔测量)和问卷测量来检查AI和青春期女孩BPD的其他特征之间的关系。此外，还将研究父母的反应对BPD特征的影响。建议的研究目标将在一项关于女孩情绪和行为健康的纵向调查(匹兹堡女孩研究：PGS)的前瞻性子研究中实现。该项目将从PGS招募110名16岁的女孩，对所有AI严重性进行抽样。这些培训和研究活动将使候选人能够对BPD病因学中的社会和生物因素进行翻译研究。

DESCRIPTION (provided by applicant): The goal of this Research Career Development Award (K01) is to provide a five-year career development and research training program that will enable the candidate to conduct research on the role of affective instability (AI) in the development of Borderline Personality Disorder (BPD) during childhood and adolescence in girls. BPD is a complex and debilitating disorder associated with frequent suicidal behavior, intense and chronic misery, and high rates of treatment utilization. BPD is usually first diagnosed in young adulthood and is disproportionately diagnosed in women. There are four key features of BPD: AI, interpersonal dysfunction, behavioral undercontrol, and identity disturbance. Major theories suggest that AI plays a primary role in the development of BPD and that parental response to affect is especially important in buffering or conferring risk for those girls with high levels of AI. However, little longitudinal research has been conducted on etiological mechanisms underlying the developmental course of BPD. To address this need, the training and research plan incorporates both behavioral and psychophysiological approaches in a longitudinal framework to investigate the role of AI in the development of other features of BPD in adolescent girls. The candidate will pursue training in developmental research methodology pertinent to adolescent girls, assessment of affect in the natural environment using ecological momentary assessment (EMA), and the psychophysiology of emotion under the mentorship of Dr. Paul Pilkonis, co-mentor Greg Siegle, and an expert team of consultants, including Drs. Rolf Loeber and Ronald Dahl. The proposed research will utilize EMA, psychophysiological (pupillometry), and questionnaire measures to examine associations between AI and other features of BPD in adolescent girls over time. Additionally, the impact of parental response to affect on features of BPD will be examined. The proposed research goals will be achieved in a prospective substudy of a longitudinal investigation of girls' emotional and behavioral health (Pittsburgh Girls Study: PGS). This project will recruit 110 16 year-old girls from the PGS, sampling the full range of AI severity. These training and research activities will place the candidate in a position to conduct translational research on social and biological factors in the etiology of BPD.