Integrated Family-Based Treatment of Co-Occurring Adolescent SUD and ADHD

对同时发生的青少年 SUD 和 ADHD 的综合家庭治疗

基本信息

  • 批准号:
    8019456
  • 负责人:
  • 金额:
    $ 12.24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-02-01 至 2015-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): For adolescents with comorbid SUD and ADHD, integrated treatment models that combine behavioral and pharmacological interventions are urgently needed to achieve lasting clinical gains for both conditions. Dr. Hogue's expertise in family-based treatment for adolescent SUDs makes him an excellent candidate to become a productive investigator in this area. The objective of this amended K02 application is to provide Dr. Hogue with training and collaborative research experiences in three core areas: (1) Behavioral Intervention Core: training in developmental psychopathology and behavioral treatment for adolescent ADHD that includes treatment planning for school and learning problems; (2) Psychopharmacology Core: training in medication intervention and compliance issues for adolescent ADHD and other co-occurring disorders, and in the conduct of medication trials for adolescent disorders; (3) Neurodevelopment Core: training in neurodevelopmental risk factors associated with ASU and ADHD and in neuroimaging (fMRI) techniques for investigating brain processes and treatment response in adolescents with SUD/ADHD. Training in these core areas will lead to development of a new treatment for ASU/ADHD, Functional Family Therapy - Integrated Model (FFT-IM), an adapted version of an empirically based model for ASU that incorporates neuropsychological assessment and an evidence-based psychostimulant medication protocol for ADHD. Training activities will culminate in a Stage I pilot study of FFT-IM involving N = 20 adolescents with SUD/ADHD. This Stage Ia pilot study of FFT-IM is designed to yield proof-of-concept data with regard to feasibility and acceptability, treatment fidelity, and effect size estimates for behavioral, developmental, and family outcomes. The quasi-experimental design will compare service utilization effects and posttreatment outcomes in 20 FFT-IM cases versus 20 TAU matched comparison cases drawn from the same geographic area who receive routine services in community clinics. Observational fidelity tools will be developed for newly developed FFT-IM components and used to evaluate adherence and competence in the pilot cases. If promising, study results would set the foundation for a randomized efficacy trial of FFT-IM. PUBLIC HEALTH RELEVANCE: ADHD is common co-occurring condition for ASU that presents a significant challenge to successful ASU treatment and maintenance of treatment gains. The career development goals described in this K02 application will lead to development of an integrated behavioral/pharmacological treatment for ASU/ADHD and prepare the Principal Investigator for an independent research career focused on developing and testing integrated models for a variety of co-occurring disorders in adolescence.
描述(由申请人提供):对于患有 SUD 和 ADHD 共病的青少年,迫切需要结合行为和药物干预的综合治疗模型,以实现这两种疾病的持久临床获益。 Hogue 博士在青少年 SUD 家庭治疗方面的专业知识使他成为该领域富有成效的研究者的优秀候选人。修订后的 K02 申请的目的是为霍格博士提供三个核心领域的培训和合作研究经验:(1)行为干预核心:针对青少年 ADHD 的发展精神病理学和行为治疗培训,包括学校和学习问题的治疗计划; (2) 精神药理学核心:针对青少年多动症和其他并发疾病的药物干预和依从性问题的培训,以及针对青少年疾病进行药物试验的培训; (3) 神经发育核心:与 ASU 和 ADHD 相关的神经发育危险因素以及用于研究 SUD/ADHD 青少年的大脑过程和治疗反应的神经影像 (fMRI) 技术的培训。这些核心领域的培训将导致针对 ASU/ADHD 的新治疗方法的开发,即功能家庭治疗 - 综合模型 (FFT-IM),这是 ASU 基于经验的模型的改编版本,其中结合了神经心理学评估和针对 ADHD 的循证精神兴奋药物方案。培训活动将在 FFT-IM 第一阶段试点研究中达到高潮,该研究涉及 N = 20 名患有 SUD/ADHD 的青少年。 FFT-IM 的 Ia 阶段试点研究旨在产生有关可行性和可接受性、治疗保真度以及行为、发育和家庭结果的效应大小估计的概念验证数据。准实验设计将比较 20 个 FFT-IM 病例与来自同一地理区域、在社区诊所接受常规服务的 20 个 TAU 匹配对照病例的服务利用效果和治疗后结果。将为新开发的 FFT-IM 组件开发观察保真度工具,并用于评估试点案例中的依从性和能力。如果有希望,研究结果将为 FFT-IM 的随机疗效试验奠定基础。 公共卫生相关性:ADHD 是 ASU 常见的并发疾病,对 ASU 的成功治疗和维持治疗效果提出了重大挑战。本 K02 申请中描述的职业发展目标将导致针对 ASU/ADHD 的综合行为/药物治疗的开发,并为首席研究员做好独立研究职业的准备,该职业专注于开发和测试青春期各种并发疾病的综合模型。

项目成果

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Aaron Hogue其他文献

Aaron Hogue的其他文献

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{{ truncateString('Aaron Hogue', 18)}}的其他基金

CoARS Administrative Supplement
CoARS 行政补充
  • 批准号:
    10535154
  • 财政年份:
    2022
  • 资助金额:
    $ 12.24万
  • 项目类别:
Family-based Recovery Support Service Network for Youth OUD
青少年 OUD 家庭康复支持服务网络
  • 批准号:
    10057199
  • 财政年份:
    2020
  • 资助金额:
    $ 12.24万
  • 项目类别:
Testing a System-level Implementation Intervention to Improve the Quality of Family-Based Services for Adolescent Substance Use
测试系统级实施干预措施,以提高针对青少年药物使用的家庭服务质量
  • 批准号:
    10403185
  • 财政年份:
    2017
  • 资助金额:
    $ 12.24万
  • 项目类别:
Testing a System-level Implementation Intervention to Improve the Quality of Family-Based Services for Adolescent Substance Use
测试系统级实施干预措施,以提高针对青少年药物使用的家庭服务质量
  • 批准号:
    9402180
  • 财政年份:
    2017
  • 资助金额:
    $ 12.24万
  • 项目类别:
Local Quality Assurance Tool for Family Therapy in Usual Care for Adolescent Substance Use
青少年药物使用日常护理家庭治疗的本地质量保证工具
  • 批准号:
    8818838
  • 财政年份:
    2015
  • 资助金额:
    $ 12.24万
  • 项目类别:
Local Quality Assurance Tool for Family Therapy in Usual Care for Adolescent Substance Use
青少年药物使用日常护理家庭治疗的本地质量保证工具
  • 批准号:
    9012070
  • 财政年份:
    2015
  • 资助金额:
    $ 12.24万
  • 项目类别:
Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADH
治疗合并症 ASU/ADH 的基于家庭的药物整合方案
  • 批准号:
    8301505
  • 财政年份:
    2011
  • 资助金额:
    $ 12.24万
  • 项目类别:
Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADH
治疗合并症 ASU/ADH 的基于家庭的药物整合方案
  • 批准号:
    8189686
  • 财政年份:
    2011
  • 资助金额:
    $ 12.24万
  • 项目类别:
Integrated Family-Based Treatment of Co-Occurring Adolescent SUD and ADHD
对同时发生的青少年 SUD 和 ADHD 的综合家庭治疗
  • 批准号:
    8233986
  • 财政年份:
    2010
  • 资助金额:
    $ 12.24万
  • 项目类别:
Integrated Family-Based Treatment of Co-Occurring Adolescent SUD and ADHD
对同时发生的青少年 SUD 和 ADHD 的综合家庭治疗
  • 批准号:
    8604380
  • 财政年份:
    2010
  • 资助金额:
    $ 12.24万
  • 项目类别:

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