Psychological Intervention Research in Pediatric Oncology

描述（由申请人提供）：项目概述：这是一份为Anne E. Kazak博士申请癌症预防与控制既定研究者奖（K05; PAR-05-145）的申请，她是宾夕法尼亚大学儿科学系教授，位于费城儿童医院肿瘤科。Kazak博士是一位知名的癌症研究者，自1991年以来一直得到联邦政府的资助。她曾担任许多多学科培训生、研究员和初级教师的研究导师，其中大多数人现在都有学术职位和联邦资助的工作。Kazak博士的工作利用社会生态框架来了解患有癌症的儿童及其家庭的适应情况，特别关注儿童癌症幸存者。她目前的研究重点是为患有癌症的儿童及其家庭开发基于证据的社会心理干预措施，使用她开发的两个模型：1)创伤后应激模型，将癌症的诊断和治疗视为潜在的创伤和持续的加班；2)儿童预防性心理社会健康模型（PPPHM），一个以预防公共卫生为导向的模型，用于指导儿童恶性肿瘤患儿及其家庭的干预措施。哈萨克博士追求这个奖项是为了把精力集中在指导和研究上。描述了一项扩大指导的计划，其中包括多学科的指导和开发小型课程，以吸引和培训更多的人从事儿童癌症（和其他严重儿童疾病）的心理社会研究和干预。该申请概述了两项拟议的研究。项目1调查正在进行的关于年轻成年幸存者创伤后应激与幸存者治疗建议依从性之间的联系。项目2扩展了Kazak博士在针对新诊断癌症患者家庭的干预措施开发方面的工作，要求为现有治疗模式的试点调整提供资金，重点是更广泛地传播这项工作。总而言之，该提案旨在增加从事癌症心理社会方面研究的研究人员队伍，并有助于Kazak博士在儿科肿瘤学中加强心理社会干预的广泛职业目标。

DESCRIPTION (provided by applicant): Project Summary: This is an application for an Established Investigator Award in Cancer Prevention and Control (K05; PAR-05-145) for Anne E. Kazak, Ph.D., Professor, Department of Pediatrics at the University of Pennsylvania, based in the Division of Oncology at The Children's Hospital of Philadelphia. Dr. Kazak is a well established cancer investigator, with continuous federal funding since 1991. She has served as a research mentor to many multidisciplinary trainees, fellows and junior faculty, the majority now with academic positions and federally funded work. Dr. Kazak's work utilizes a social ecological framework to understand the adaptation of children with cancer and their families, with a particular focus on pediatric cancer survivorship. Her current research is focused on the development of evidence-based psychosocial interventions for children with cancer and their families, using two models that she has developed: 1) A posttraumatic stress model, viewing the diagnosis and treatment of cancer as potentially traumatic and persistent overtime; and 2) The Pediatric Preventative Psychosocial Health Model (PPPHM), a preventative public health oriented model to guide interventions for children with pediatric malignancies and their families. Dr. Kazak is pursuing this award in order to focus her efforts on mentoring and research. A plan for expanded mentoring is described, with multidisciplinary mentees and the development of mini-courses to attract and train more individuals in psychosocial research and interventions in pediatric cancer (and other serious pediatric illnesses). The application outlines two proposed studies. Project 1 investigates linkages between ongoing research on posttraumatic stress in young adult survivors and adherence to survivorship treatment recommendations. Project 2 extends Dr. Kazak's work on intervention development for families of patients newly diagnosed with cancer, requesting funds to pilot adaptations of the existing treatment model, with an emphasis on broader dissemination of this work. In sum, the proposal aims to increase the cadre of investigators conducting research on psychosocial aspects of cancer and contribute to Dr. Kazak's broad career goals of enhancing psychosocial intervention in pediatric oncology. Lay Summary: Dr. Kazak is an established investigator who studies psychological adjustment of children with cancer and their families. She has mentored many multidisciplinary trainees and junior faculty. In this application she presents a plan for expanded mentoring and two research projects related to her work on intervention development and dissemination.