Quantifying and modeling influenza viral dynamics and host responses

流感病毒动态和宿主反应的量化和建模

• 批准号: 8321729
• 负责人: Paul G. Thomas
• 金额: $ 64.81万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321729
• 关键词: Address; Antiviral Response; Area; Biology; Calculi; Cell Communication; Cells; Cellular Structures; Characteristics; Chickens; Complex; Computer Simulation; Data; Ducks; Employee Strikes; Equation; Experimental Models; Family suidae; Ferrets; Focal Infection; Genes; Genetic; Growth; Health; Human; Image; Imaging Techniques; Immune response; Immunofluorescence Immunologic; In Vitro; Individual; Infection; Influenza; Influenza A virus; Integration Host Factors; Investigation; Kinetics; Knowledge; Lead; Light; Location; Measurement; Measures; Modeling; Morbidity - disease rate; Mus; Nature; Outcome; Phenotype; Population; Property; Role; Series; System; Time; Variant; Viral; Virulence Factors; Virus; Virus Diseases; base; computerized tools; design; flu; improved; in vivo; influenzavirus; insight; laser capture microdissection; mathematical model; mortality; novel; pathogen; programs; research study; response; simulation; trait; treatment strategy; virus host interaction

项目成果

Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers.

• DOI: 10.1128/mbio.02107-14
• 发表时间: 2014-12-09
• 期刊: mBio
• 影响因子: 6.4
• 作者: Oshansky CM;Wong SS;Jeevan T;Smallwood HS;Webby RJ;Shafir SC;Thomas PG
• 通讯作者: Thomas PG

Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia.

• DOI: 10.1016/j.bbmt.2014.09.027
• 发表时间: 2015-01
• 期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
• 影响因子: 4.3
• 作者: Perko, Ross;Kang, Guolian;Sunkara, Anusha;Leung, Wing;Thomas, Paul G.;Dallas, Mari H.
• 通讯作者: Dallas, Mari H.

The two faces of heterologous immunity: protection or immunopathology.

异源免疫的两个方面：保护或免疫病理学。

• DOI: 10.1189/jlb.0713386
• 发表时间: 2014
• 期刊: Journal of leukocyte biology
• 影响因子: 5.5
• 作者: Sharma,Shalini;Thomas,PaulG
• 通讯作者: Thomas,PaulG

Interrogating the relationship between naïve and immune antiviral T cell repertoires.

• DOI: 10.1016/j.coviro.2013.06.011
• 发表时间: 2013-08
• 期刊: CURRENT OPINION IN VIROLOGY
• 影响因子: 5.9
• 作者: La Gruta, Nicole L.;Thomas, Paul G.
• 通讯作者: Thomas, Paul G.