Information Engineering

信息工程核心B将开发一个生物信息学基础设施，以实现合作， 研究项目和更广泛的癌症研究社区之间的数据共享。的信息 工程核心B将开发数据库和分析工具，以便于生成可测试的 假设该基础设施包括：（1）一个数据库，用于存储注释的基因表达签名， 模式和集合，以及一套相互比较的工具套件，和（2）体细胞突变数据库和功能 分析工具，整合蛋白质家族成员之间现有的突变数据。这种基础设施将 允许P01研究人员更好地利用已发表的基因表达特征和体细胞突变数据， 以及协作和共享数据。这将允许他们相互比较他们的基因签名， 他们发表和功能相关的基因签名，模式，和集。此外，它将允许 他们将特定的突变与独特的基因表达和蛋白质组特征联系起来， 蛋白质家族和功能域的谱。广泛的生物信息学，计算， 数学和统计技术将被应用于创建这一基础设施。这个核心将提供 生物信息学和数据管理资源，以个别研究项目和分子分析和 病理学和管理与分析核心。

The Information Engineering Core B will develop a bioinformatics infrastructure to enable collaboration and data sharing among research projects and the wider cancer research community. The Information Engineering Core B will develop databases and analysis tools to facilitate the generation of testable hypotheses. This infrastructure includes: (1) a databaseto store annotated gene expression signatures, patterns and sets, and a set intercomparison tools suite, and (2) a somatic mutation database and functional analysis tool that integrates existing mutation data amongst protein family members. This infrastructure will allow P01 investigators to better utilize published gene expression signatures and somatic mutation data, as well as to collaborate and share data. It will permit them to intercompare their gene signatures and compare them to published and functionally-associatedgene signatures, patterns, and sets. Further, it will allow them to associate specific mutations to unique gene expression and proteomic signatures across a spectrum of protein families and functional domains. A broad range of bioinformatics, computational, mathematical, and statistical techniques will be applied to create this infrastructure. This core will provide bioinformatics and data management resources to individual research projects and the Molecular Profiling & Pathology and Administration & Analysis cores.