Information Engineering

信息工程核心B将开发生物信息学基础设施，以实现协作和 研究项目和更广泛的癌症研究社区之间的数据共享。信息 工程核心B将开发数据库和分析工具，以促进可测试的生成 假设。该基础设施包括：(1)存储带注释的基因表达签名的数据库， 模式和集合，以及一组相互比较工具套件，以及(2)体细胞突变数据库和功能 整合蛋白质家族成员中现有突变数据的分析工具。这一基础设施将 允许P01调查人员更好地利用已公布的基因表达签名和体细胞突变数据，如 以及协作和共享数据。这将允许他们相互比较他们的基因签名并进行比较 它们与已发表的和功能相关的基因签名、模式和集合有关。此外，它将允许 它们将特定的突变与独特的基因表达和蛋白质组签名相关联 蛋白质家族和功能结构域的谱。广泛的生物信息学，计算， 将应用数学和统计技术来创建这一基础设施。这个核心将提供 为个人研究项目提供生物信息学和数据管理资源，以及 病理学与管理与分析核心。

The Information Engineering Core B will develop a bioinformatics infrastructure to enable collaboration and data sharing among research projects and the wider cancer research community. The Information Engineering Core B will develop databases and analysis tools to facilitate the generation of testable hypotheses. This infrastructure includes: (1) a databaseto store annotated gene expression signatures, patterns and sets, and a set intercomparison tools suite, and (2) a somatic mutation database and functional analysis tool that integrates existing mutation data amongst protein family members. This infrastructure will allow P01 investigators to better utilize published gene expression signatures and somatic mutation data, as well as to collaborate and share data. It will permit them to intercompare their gene signatures and compare them to published and functionally-associatedgene signatures, patterns, and sets. Further, it will allow them to associate specific mutations to unique gene expression and proteomic signatures across a spectrum of protein families and functional domains. A broad range of bioinformatics, computational, mathematical, and statistical techniques will be applied to create this infrastructure. This core will provide bioinformatics and data management resources to individual research projects and the Molecular Profiling & Pathology and Administration & Analysis cores.