HUMORAL AND CELLULAR IMMUNE RESPONSES TO TUMOR ASSOCIATED ANTIGENS (TAA) PATIENT

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心赠款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 脑肿瘤是儿童癌症死亡的主要原因，也是成人癌症死亡的重要原因。尽管在治疗其他类型的恶性肿瘤方面取得了重大进展，但治疗脑肿瘤的进展一直非常缓慢。此外，那些确实存活下来的患者经常面临疾病和治疗方法带来的重大长期并发症。这些并发症可能包括神经心理和智力功能的进行性下降，继发性恶性肿瘤的发展，神经内分泌异常和永久性听力损失。德克萨斯州儿童癌症中心（TCCC）的脑肿瘤研究计划专注于确定比目前可用的治疗方法更有效，毒性更低的脑肿瘤新治疗方法。在这项提案中，我们寻求对一个新项目的支持，该项目旨在为所有脑肿瘤中最具破坏性的恶性胶质瘤开发一种创新的免疫治疗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Brain tumors are the leading cause of mortality in children with cancer and are a significant cause of cancer mortality in adults as well. Despite significant advances in the treatment of other types of malignancies, progress in treating brain tumors has been painfully slow. Moreover, those patients who do survive frequently face major, long-term complications from their disease and the therapies used to treat them. These complications may include progressive decline in neuropsychological and intellectual functioning, the development of secondary malignancies, neuro-endocrine abnormalities, and permanent hearing loss. The Texas Childrens Cancer Centers (TCCC) brain tumor research programs is focused on identifying new treatment approaches for brain tumors that are more effective and less toxic than currently available treatments. In this proposal we seek support for a novel project aimed at developing an innovative immunotherapeutic treatment strategy for the most devastating of all brain tumors known as malignant gliomas.