THE EFFECT OF LEPTIN THERAPY ON LIPID METABOLISM IN HIV-LIPODYSTROPHY

瘦素治疗对 HIV 脂肪代谢障碍患者脂质代谢的影响

• 批准号: 8356763
• 负责人: ASHOK BALASUBRAMANYAM
• 金额: $ 0.7万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356763
• 关键词: Adipocytes; Carbohydrates; Clinical Research; Esterification; Fatty acid glycerol esters; Funding; Grant; HIV; HIV-Associated Lipodystrophy Syndrome; Hepatic; Hypertriglyceridemia; Kinetics; Leptin; Lipids; Lipodystrophy; Lipolysis; National Center for Research Resources; Nonesterified Fatty Acids; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Very low density lipoprotein; apolipoprotein B-100; cost; fatty acid oxidation; improved; lipid metabolism; oxidation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 1. HIV Lipodystrophy Syndrome (HLS) is associated with: a) accelerated whole-body lipid kinetics with an increase in total and net lipolysis. b) absence of a proportional increase in fatty acid oxidation. c) increased intra- adipocyte and intra-hepatic re-esterification. d) increased turnover rate of apoB-100. 2. Leptin therapy in HLS will stimulate fat oxidation and shift fuel selection for energy requirements from carbohydrate to lipid. Free fatty acids released as a result of lipolysis will be shunted away from intra-hepatic re-esterification, and VLDL apoB-100 synthesis towards oxidative disposal, thus improving hypertriglyceridemia.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 1. HIV脂肪营养不良综合征（HLS）与以下相关：a）加速的全身脂质动力学，伴随总脂解和净脂解的增加。B）脂肪酸氧化不成比例增加。 c）增加的脂肪细胞内和肝内再酯化。 d）增加apoB-100的周转率。 2. HLS中的瘦素治疗将刺激脂肪氧化并将能量需求的燃料选择从碳水化合物转移到脂质。由于脂解释放的游离脂肪酸将从肝内再酯化和VLDL apoB-100合成转向氧化处理，从而改善高脂血症。