Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (U54)
非典型糖尿病个体识别和研究中心 (U54)
基本信息
- 批准号:10660916
- 负责人:
- 金额:$ 207.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-10 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAncillary StudyAutoimmuneAutoimmune DiabetesBiological Specimen BanksC-PeptideCategoriesCharacteristicsClassificationClinicClinicalClinical ProtocolsCluster AnalysisCollaborationsCollectionColoradoCommunicationComplexComplex MixturesComplicationCore FacilityDNADataData Storage and RetrievalDatabasesDevelopmentDiabetes MellitusDiagnosisDiseaseEnvironmental Risk FactorEpigenetic ProcessEtiologyEvaluationFamily StudyFloridaFoundationsFunctional disorderFutureGeneticGenotypeGoalsHeterogeneityImmunologyIndianaIndividualInstitutionInsulinInsulin-Dependent Diabetes MellitusInternationalInvestigationLongitudinal StudiesMedicalMedicineMetabolicMiningMissionMitochondriaMolecularMolecular DiagnosisMulticenter TrialsNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryNon-Insulin-Dependent Diabetes MellitusObesityParticipantPathologicPatient RecruitmentsPatientsPersonsPhenotypePhysiologyPopulationProinsulinRegistriesResearchResearch PersonnelResourcesSamplingScientistSecureSerumSingle Nucleotide PolymorphismSubgroupSurfaceSymptomsSyndromeSystemTherapeuticUniversitiesVariantWashingtonWorkYouthadiponectinbiobankbiomarker identificationcohortcollegedata sharingdatabase of Genotypes and Phenotypesdesigndiabetes pathogenesisdiverse dataexomefollow-upgenetic analysisgenetic informationgenetic registrygenetic variantgenome sequencingimprovedinsightislet cell antibodylearning strategymetabolomicsmitochondrial genomenovelnovel diagnosticsnovel therapeuticsoutreachparticipant enrollmentpatient registryphenotypic dataprospectiverecruittreatment responseunsupervised learningweb site
项目摘要
Diabetes is traditionally classified in two broad categories: autoimmune Type 1 and obesity-related Type 2.
Numerous phenotypically and etiologically distinct forms exist and are emerging, collectively termed “atypical
diabetes” (AD), that do not fit into either category. We hypothesize that AD comprises a spectrum that includes
numerous forms, both known (e.g, MODY/monogenic, Latent Autoimmune Diabetes of Adults, Ketosis-Prone
Diabetes) and unknown. We propose to establish the Center for Atypical Diabetes Research and Evaluation
(CADRE). The goals of CADRE are to (1) identify and define comprehensively the forms of AD; and (2) establish
an extensive database and repository of biosamples from AD patients. Defining the forms of AD is challenging
because the etiology of AD can range from a single gene variant to a highly complex mixture of genetics,
epigenetics and environmental factors. To identify patients with AD, and then to define the forms, we will use a
two-pronged approach. Approach (a) will use clustering analysis of genotypic and phenotypic data from diverse
groups of patients with diabetes. We have recruited 15 domestic and international population cohorts with data
on more than 33,000 patients with diabetes. Further, we have recruited six diabetes study clinics (Baylor College
of Medicine [BCM], University of Washington [UW], Indiana University [IU], Emory University, University of
Colorado, and SUNY Downstate) who will prospectively recruit patients. The Juvenile Diabetes Research
Foundation will facilitate recruitment from patient groups. The Administrative Core at BCM will work with cohorts
and clinics to obtain data. The University of South Florida (USF) will filter data for AD and separate patients into
phenotypically homogenous clusters that can be diagnosed based on genetic and clinical features unique to the
cluster. Approach (b) will identify monogenic, oligogenic and mitochondrial forms of AD from patients enrolled in
genetics registries (BCM) and a family study with genetic data (Botnia). The BCM registries include patients
referred to the Undiagnosed Disease Network. All patients will undergo whole-exome and mitochondrial genome
sequencing (Cores at BCM), single-nucleotide polymorphism variant analysis (Oxford), metabolomic analysis
(Duke) and phenotypic analysis of C-peptide, adiponectin, proinsulin, islet autoantibodies, and serum insulin
DNA levels (Cores at UW and IU). To establish the database and biorepository, we will invite patients with AD
to participate in sample donation and longitudinal follow-up via the cohorts and clinics. Data and samples will be
transferred to the Database and Biorepository Core at USF, with input and tracking implemented using the
successful framework developed by USF for large multicenter trials. Data will be made available through the
NIDDK and a CADRE website and samples will be made available through ancillary study application. Ongoing
patient recruitment to expand the database and biorepository will occur through the study clinics and clinician
referral through the CADRE website. Overall, CADRE will be built on a foundation of existing, successful core
facilities and computational systems to create a lasting resource that will substantially advance AD research.
传统上将糖尿病分为两大类:自身免疫性1型糖尿病和肥胖相关的2型糖尿病。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Age Ain't Nothing But a Number . . . or Is It?
年龄只是一个数字。
- DOI:10.2337/dci23-0013
- 发表时间:2023
- 期刊:
- 影响因子:16.2
- 作者:Redondo,MariaJ;vanRaalte,DaniëlH
- 通讯作者:vanRaalte,DaniëlH
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ASHOK BALASUBRAMANYAM其他文献
ASHOK BALASUBRAMANYAM的其他文献
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{{ truncateString('ASHOK BALASUBRAMANYAM', 18)}}的其他基金
Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (U54)
非典型糖尿病个体识别和研究中心 (U54)
- 批准号:
9597055 - 财政年份:2018
- 资助金额:
$ 207.5万 - 项目类别:
Role of Islet Injury and Autoimmunity in T2D Beta Cell Dysfunction
胰岛损伤和自身免疫在 T2D β 细胞功能障碍中的作用
- 批准号:
9768465 - 财政年份:2015
- 资助金额:
$ 207.5万 - 项目类别:
Role of Islet Injury and Autoimmunity in T2D Beta Cell Dysfunction
胰岛损伤和自身免疫在 T2D β 细胞功能障碍中的作用
- 批准号:
9330149 - 财政年份:2015
- 资助金额:
$ 207.5万 - 项目类别:
Adipose Tissue is a significant reservoir for HIV
脂肪组织是艾滋病毒的重要储存库
- 批准号:
8842411 - 财政年份:2014
- 资助金额:
$ 207.5万 - 项目类别:
Arginine and nitric oxide synthesis in the pathogenesis of ketosis-prone diabetes
酮症糖尿病发病机制中的精氨酸和一氧化氮合成
- 批准号:
8813384 - 财政年份:2014
- 资助金额:
$ 207.5万 - 项目类别:
Adipose Tissue is a significant reservoir for HIV
脂肪组织是艾滋病毒的重要储存库
- 批准号:
9291547 - 财政年份:2014
- 资助金额:
$ 207.5万 - 项目类别:
Adipose Tissue is a significant reservoir for HIV
脂肪组织是艾滋病毒的重要储存库
- 批准号:
8914490 - 财政年份:2014
- 资助金额:
$ 207.5万 - 项目类别:
DIET/EXERCISE, NIACIN, FENOFIBRATE FOR HIV LIPODYSTROPHY
饮食/运动、烟酸、非诺贝特治疗 HIV 脂肪代谢障碍
- 批准号:
8356764 - 财政年份:2010
- 资助金额:
$ 207.5万 - 项目类别:
THE EFFECT OF LEPTIN THERAPY ON LIPID METABOLISM IN HIV-LIPODYSTROPHY
瘦素治疗对 HIV 脂肪代谢障碍患者脂质代谢的影响
- 批准号:
8356763 - 财政年份:2010
- 资助金额:
$ 207.5万 - 项目类别:
ESTIMATION OF BETA CELL MASS EVOLUTION IN KETOSIS-PRONE DIABETES
酮症倾向糖尿病中 β 细胞质量进化的估计
- 批准号:
8356774 - 财政年份:2010
- 资助金额:
$ 207.5万 - 项目类别:
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