N-ACETYLCYSTEINE AS A POTENTIAL TREATMENT FOR METHAMPHETAMINE DEPENDENCE

N-乙酰半胱氨酸作为甲基苯丙胺依赖的潜在治疗方法

• 批准号: 8356780
• 负责人: Thomas Frederick Newton
• 金额: $ 0.59万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356780
• 关键词: Acetylcysteine; Biological Availability; Clinical Research; Cues; Dose; Double-Blind Method; Funding; Grant; Methamphetamine dependence; National Center for Research Resources; Participant; Pharmaceutical Preparations; Placebo Control; Placebos; Principal Investigator; Procedures; Reporting; Research; Research Infrastructure; Resources; Smoke; Source; United States National Institutes of Health; Visual; analog; cost; craving; design; discontinuation trial; treatment duration; virtual reality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Twenty participants will complete procedures during treatment with placebo, NAC 1800mg, and NAC 3600mg, using within-subject, double-blind, placebo-controlled design. After 2 days of treatment with study medication, cue-induced craving will be assessed using visual analogue rating scales prior to and after exposing participants to MA and neutral cues using our newly developed virtual reality (VR) apparatus. Participants will then complete sessions in which they receive a non-contingent dose of 10mg smoked MA (equivalent to 5mg IV MA) or placebo followed by 5 choices between receiving identical doses or receiving nothing. One session will be conducted at 10am and the other at 1pm. The order of availability of MA and placebo will be counterbalanced within each participant. They will smoke the MA, and given the bioavailability of smoked MA is about 50% (Harris and colleagues reported absolute bioavailability of 37.4 14.2% (Harris, Boxenbaum et al. 2003)) we will load the pipe 10mg MA to approximate the effects of 5mg IV MA. Any alterations in the reinforcing effects of MA associated with NAC treatment will be evident as changes in the number of choices made for MA. After discontinuation of study medication participants will be discharged.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 使用主题内，双盲，安慰剂对照设计的安慰剂，NAC 1800mg和NAC 3600mg在接受安慰剂，NAC 1800mg和NAC 3600mg治疗期间，有20名参与者将完成程序。 在用研究药物治疗2天后，将使用我们新开发的虚拟现实（VR）设备在将参与者暴露于MA和中性线索之前和之后，使用视觉模拟评级量表来评估提示引起的渴望。 然后，参与者将完成会议，在其中接受10mg熏制的MA（相当于5mg IV MA）或安慰剂的非牙剂剂量，然后在接受相同剂量或什么都不接受的情况下进行5个选择。一场会议将在上午10点进行，另一个会议在下午1点进行。 MA和安慰剂的可用性顺序将在每个参与者中平衡。 他们将吸烟MA，鉴于烟熏MA的生物利用度约为50％（Harris及其同事报告的绝对生物利用度为37.4 14.2％（Harris，Boxenbaum etal。2003）），我们将加载10mg MA的管道以近似5mg IV MA的影响。 随着对MA选择的选择数量的变化，MA与NAC治疗相关的增强作用的任何变化都将显而易见。 停用研究药物后，将出院。