N-ACETYLCYSTEINE AS A POTENTIAL TREATMENT FOR METHAMPHETAMINE DEPENDENCE

N-乙酰半胱氨酸作为甲基苯丙胺依赖的潜在治疗方法

• 批准号: 8356780
• 负责人: Thomas Frederick Newton
• 金额: $ 0.59万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356780
• 关键词: Acetylcysteine; Biological Availability; Clinical Research; Cues; Dose; Double-Blind Method; Funding; Grant; Methamphetamine dependence; National Center for Research Resources; Participant; Pharmaceutical Preparations; Placebo Control; Placebos; Principal Investigator; Procedures; Reporting; Research; Research Infrastructure; Resources; Smoke; Source; United States National Institutes of Health; Visual; analog; cost; craving; design; discontinuation trial; treatment duration; virtual reality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Twenty participants will complete procedures during treatment with placebo, NAC 1800mg, and NAC 3600mg, using within-subject, double-blind, placebo-controlled design. After 2 days of treatment with study medication, cue-induced craving will be assessed using visual analogue rating scales prior to and after exposing participants to MA and neutral cues using our newly developed virtual reality (VR) apparatus. Participants will then complete sessions in which they receive a non-contingent dose of 10mg smoked MA (equivalent to 5mg IV MA) or placebo followed by 5 choices between receiving identical doses or receiving nothing. One session will be conducted at 10am and the other at 1pm. The order of availability of MA and placebo will be counterbalanced within each participant. They will smoke the MA, and given the bioavailability of smoked MA is about 50% (Harris and colleagues reported absolute bioavailability of 37.4 14.2% (Harris, Boxenbaum et al. 2003)) we will load the pipe 10mg MA to approximate the effects of 5mg IV MA. Any alterations in the reinforcing effects of MA associated with NAC treatment will be evident as changes in the number of choices made for MA. After discontinuation of study medication participants will be discharged.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 20名参与者将在安慰剂、NAC 1800 mg和NAC 3600 mg的治疗期间完成治疗，采用受试者内、双盲、安慰剂对照设计。在学习药物治疗2天后，将使用我们新开发的虚拟现实(VR)设备，在参与者接触MA和中性线索之前和之后使用视觉模拟评分表来评估线索诱导的渴求。然后参与者将完成治疗，他们接受非偶然剂量的10毫克烟熏MA(相当于5毫克静脉注射MA)或安慰剂，然后在接受相同剂量或什么都不接受之间进行5个选择。一节课在上午十时进行，另一节在下午一时进行。MA和安慰剂的使用顺序将在每个参与者之间保持平衡。他们将吸烟MA，鉴于吸烟MA的生物利用度约为50%(Harris及其同事报告的绝对生物利用度为37.414.2%(Harris，Boxenbaum等人。2003)，我们将向管道加载10 mg MA，以接近5 mg IV MA的效果。与NAC治疗相关的MA增强效果的任何变化都将明显地体现为MA选择的数量的变化。停止药物治疗后，参与者将出院。