THE EFFECTS OF DOXAZOSIN ON THE CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF COCAINE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这将是一项双盲、安慰剂对照、受试者内、住院患者评价静脉注射可卡因和多沙唑嗪之间的潜在相互作用。感兴趣的候选人在过去两周内通过吸烟静脉注射途径使用可卡因，并且没有寻求治疗，并且可以在综合临床研究中心（GCRC）住院28天，将收到以下解释： 研究目的和要求。如有兴趣，将允许受试者审阅、询问并签署知情同意书。提供签署的知情同意书后，受试者进入研究的筛选评估阶段。如果受试者符合所有入选标准，则将入组并随机分配至研究。非寻求治疗的可卡因依赖志愿者将随机接受安慰剂（n=10）或多沙唑嗪（n=10）。可卡因给药后将评估心血管指标和主观效应评级。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This will be a double-blind, placebo-controlled, within-subject, inpatient evaluation of potential interactions between intravenous cocaine and doxazosin. Interested candidates who have used cocaine by the smoked intravenous route in the past two weeks and are not seeking treatment, and are available for the 28 days of confinement as a hospital inpatient in the General Clinical Research Center (GCRC), will receive an explanation of the study purpose and requirement. If interested, the candidates will be allowed to review, inquire about and sign the informed consent. After providing signed informed consent, subjects proceed to the screening assessment phase of the study. If subjects meet all entry criteria, they will be enrolled and randomized into the study. Nontreatment-seeking cocaine dependent volunteers will be randomized to receive placebo (n=10) or doxazosin (n=10). Cardiovascular measures and subjective effects ratings will be assessed following cocaine administration.