THE EFFECTS OF DOXAZOSIN ON THE CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF COCAINE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这将是一项双盲、安慰剂对照、受试者内部、住院患者对静脉注射可卡因和多沙唑嗪之间潜在相互作用的评估。感兴趣的候选人如果在过去两周内通过吸烟静脉途径使用可卡因，并且没有寻求治疗，并且可以作为普通临床研究中心(GCRC)的住院患者接受28天的监禁，将收到关于 研究目的和要求。如果有兴趣，候选人将被允许审查、查询和签署知情同意书。在提供签署的知情同意书后，受试者进入研究的筛查评估阶段。如果受试者符合所有的进入标准，他们将被登记并随机进入研究。未寻求治疗的可卡因依赖志愿者将随机接受安慰剂(n=10)或多沙唑嗪(n=10)。在服用可卡因后，将评估心血管测量和主观效果评级。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This will be a double-blind, placebo-controlled, within-subject, inpatient evaluation of potential interactions between intravenous cocaine and doxazosin. Interested candidates who have used cocaine by the smoked intravenous route in the past two weeks and are not seeking treatment, and are available for the 28 days of confinement as a hospital inpatient in the General Clinical Research Center (GCRC), will receive an explanation of the study purpose and requirement. If interested, the candidates will be allowed to review, inquire about and sign the informed consent. After providing signed informed consent, subjects proceed to the screening assessment phase of the study. If subjects meet all entry criteria, they will be enrolled and randomized into the study. Nontreatment-seeking cocaine dependent volunteers will be randomized to receive placebo (n=10) or doxazosin (n=10). Cardiovascular measures and subjective effects ratings will be assessed following cocaine administration.