THE EFFECTS OF DOXAZOSIN ON THE CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF COCAINE
THE EFFECTS OF DOXAZOSIN ON THE CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF COCAINE
批准号:
8356781
负责人:
Thomas Frederick Newton
金额:
$1.07万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-12-01 至 2011-11-30
关键词:
Cardiovascular systemClinical ResearchCocaineDouble-Blind MethodDoxazosinEnrollmentEvaluationFundingGrantHospitalsInformed ConsentInpatientsIntravenousMeasuresNational Center for Research ResourcesPhasePlacebo ControlPlacebosPrincipal InvestigatorRandomizedResearchResearch InfrastructureResourcesRouteScreening procedureSmokeSourceUnited States National Institutes of Healthcocaine usecostinterestmeetingsvolunteer
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
This will be a double-blind, placebo-controlled, within-subject, inpatient evaluation of potential interactions between intravenous cocaine and doxazosin. Interested candidates who have used cocaine by the smoked intravenous route in the past two weeks and are not seeking treatment, and are available for the 28 days of confinement as a hospital inpatient in the General Clinical Research Center (GCRC), will receive an explanation of
the study purpose and requirement. If interested, the candidates will be allowed to review, inquire about and sign the informed consent. After providing signed informed consent, subjects proceed to the screening assessment phase of the study. If subjects meet all entry criteria, they will be enrolled and randomized into the study. Nontreatment-seeking cocaine dependent volunteers will be randomized to receive placebo (n=10) or doxazosin (n=10). Cardiovascular measures and subjective effects ratings will be assessed following cocaine administration.
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