SENSITIVE MEMORY TESTS FOR DIFFERENTIATING MCI SUBGROUPS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该研究项目是2005年阿尔茨海默病研究中心（ADRC）拨款的一部分。这项工作的主要目标是确定敏感的行为任务与眼动追踪技术一起是否会揭示MCI患者的表现特征，这对预测阿尔茨海默病或其他痴呆症的发作是有用的。总体计划是测试60名MCI患者、60名匹配的正常对照（NC）受试者、30名阿尔茨海默病（AD）患者和一组30名无痴呆（PD）的帕金森病患者。所有受试者均从ADRC临床核心招募。每个受试者每年接受两项陈述性记忆任务和一项非陈述性记忆任务的测试，并进行眼动追踪。我们已经成功地在这些受试者中进行了优先注视任务和眼动追踪，目前正在收集第2年/第3年的数据。这项工作的一个重要贡献是能够比现在更快地诊断即将到来的认知功能下降的MCI患者，此时神经系统受损较少，因此更有可能从治疗干预中受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project is part of an Alzheimer's Disease Research Center (ADRC) grant awarded in 2005. The major goal of this work is to determine whether sensitive behavioral tasks, together with eye-tracking technology, will reveal a profile of performance in MCI patients that is useful in predicting the onset of Alzheimer's Disease or other dementias. The overall plan is to test 60 MCI patients, 60 matched normal control (NC) subjects, 30 patients with Alzheimer's Disease (AD) and a group of 30 Parkinson's Disease patients without dementia (PD). All subjects are recruited from the ADRC Clinical Core. Each subject is tested yearly on two declarative memory tasks and one nondeclarative memory task, together with eye-tracking. We have successfully administered the preferential looking task together with eye-tracking in these subjects and are currently collecting Year2/Year 3 data. An important contribution from this work would be the ability to diagnose sooner than is now possible in MCI patients oncoming cognitive decline, at a time when the nervous system is less compromised and, accordingly, more likely to benefit from therapeutic intervention.