ESTABLISHMENT OF A TRANSGENIC MONKEY MODEL OF HUNTINGTON?S DISEASE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们的目标是继续描述现有的两只目前九个月大的HD猴子和新一代HD猴子的特征。因此，将建立一个HD Money创始人队列，以根据本研究的建议进行进一步描述。这项应用建议继续监测HD猴子队列中的疾病发展，并通过非侵入性成像和认知行为测试监测症状的发展。这个应用程序的主要目标是对HD猴子进行深入的表征，并建立一个具有已知基因和表型的HD猴子队列。因此，我们将评估HD猴子模型是否比啮齿动物模型更能概括人类的HD。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our objective is to continue characterizing the two existing HD monkeys, currently nine months old, and the new generation of HD monkeys. Thus a cohort of HD monkey founders will be established for further characterization as proposed in this study. This application proposes to continue monitoring disease development among the cohort of HD monkeys and monitoring the development of symptoms by non-invasive imaging and cognitive behavioral tests. The primary goals of this application are to perform in-depth characterization on HD monkeys and establish a cohort of HD monkeys with known genotypes and phenotypes. Thus we will evaluate if the HD monkey model is a better model to recapitulate HD in humans than a rodent model.