IMMUNE RESPONSES TO TUBERCULOSIS IN HIV POSITIVE AND HIV NEGATIVE INDIVIDUALS

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 由于艾滋病的流行继续推动全球结核病（TB）的发病率，因此了解人类免疫系统如何在HIV阳性和HIV阴性环境中对TB做出反应非常重要。这对于设计预防结核病的疫苗至关重要。由CD 4+和CD 8 + T细胞介导的完整适应性免疫应答对于控制结核分枝杆菌（Mtb）感染是必不可少的， 它们的效应子功能、发育成记忆细胞和调节的特征很差。我们正在表征结核特异性免疫反应的进展及其在接受抗生素治疗的个体中的调节。我们正在研究在标准结核病抗生素治疗之前和期间HIV阴性和HIV阳性个体中Mtb抗原特异性免疫应答的调节。 这些研究的患者入组正在Grady医院进行，基础科学（Rengarajan）和临床（Ray）研究者密切合作。 更新：我们最近完成了一项研究，重点是潜伏性T感染的记忆反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. As the AIDS pandemic continues to fuel rates of tuberculosis (TB) worldwide, it is important to understand how the human immune system responds to TB in both HIV-positive and HIV-negative settings. This is critical for designing vaccines that protect against TB disease. Intact adaptive immune responses mediated by CD4+ and CD8+ T cells are essential for controlling infection with Mycobacterium tuberculosis (Mtb) but their effector functions, development into memory cells and regulation are poorly characterized. We are characterizing the progression of TB-specific immune responses and their regulation within an individual undergoing antibiotic treatment. We are studying the regulation of Mtb antigen-specific immune responses in HIV negative and HIV positive individuals before and during standard tuberculosis antibiotic therapy. Patient enrollment for these studies is ongoing at Grady Hospital in close partnership between basic science (Rengarajan) and clinical (Ray) investigators. UPDATE: We have recently completed a study focusing on memory responses in latent T infection.