CELLULAR IMMUNE RESPONSES TO ACELLULAR PERTUSSIS VACCINATION IN INFANTS

婴儿无细胞百日咳疫苗接种的细胞免疫反应

• 批准号: 8357559
• 负责人: Jyothi Rengarajan
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357559
• 关键词: Antibody Formation; Antigens; Basic Science; Cellular Immunity; Cessation of life; Childhood; Clinical Sciences; Collaborations; Communicable Diseases; Complex; Data; Diphtheria; Disease; Foundations; Funding; Future; Goals; Grant; Immune response; Immunization; Infant; Intervention; Life; Life Expectancy; Measles; Mediating; Medical; Mumps; National Center for Research Resources; Neonatal; Pertussis; Poliomyelitis; Primates; Principal Investigator; Public Health; Rana; Research; Research Infrastructure; Resources; Rubella; Source; T cell response; Tetanus; Tuberculosis; United States National Institutes of Health; Vaccination; Vaccines; base; cost; cost effective; design; insight; neonate; novel vaccines; pediatric department; prevent; tool; vaccine efficacy; vaccine-induced immunity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Vaccination is the most cost-effective medical and public health intervention known to prevent death and disease worldwide. Vaccines have been instrumental in increasing life expectancy and reducing the burden of childhood diseases like mumps, polio, measles, rubella, diphtheria, tetanus and pertussis. However, the mechanisms that mediate the efficacy of these vaccines remain unclear. Indeed, in general, immune responses to vaccination in infants are poorly understood and have not been well studied with modern immunological tools. Moreover, most vaccine efficacy studies have focused on protective antibody responses and much less is known about cell-mediated immunity and antigen-specific T cell responses following immunization. Understanding the immunological basis of successful vaccines would provide important insights for designing new vaccines for complex infectious diseases like tuberculosis. The primary goal of this study is to examine neonatal T cell responses induced by acellular pertussis vaccination during the first year of life. This study represents a close collaboration between Dr. Rana Chakraborty at the Department of Pediatrics and the Ponce Center and Dr. Rengarajan at the Division of Infectious Disease and the Emory Vaccine Center and takes advantage of existing clinical and basic science expertise and infrastructure within the two groups. Data generated through these exploratory studies will lay the foundation for future detailed studies on vaccine-induced immunity in neonates.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 疫苗接种是目前已知的在全球范围内预防死亡和疾病的最具成本效益的医疗和公共卫生干预措施。疫苗在延长预期寿命和减少流行性腮腺炎、脊髓灰质炎、麻疹、风疹、白喉、破伤风和百日咳等儿童疾病负担方面发挥了重要作用。然而，介导这些疫苗功效的机制仍不清楚。事实上，一般来说，婴儿对疫苗接种的免疫反应知之甚少，也没有用现代免疫学工具进行过很好的研究。此外，大多数疫苗效力研究集中于保护性抗体应答，而对免疫后的细胞介导的免疫和抗原特异性T细胞应答知之甚少。了解成功疫苗的免疫学基础将为设计用于结核病等复杂传染病的新疫苗提供重要见解。本研究的主要目的是检查新生儿T细胞反应诱导的无细胞百日咳疫苗接种在生命的第一年。 这项研究代表了儿科系和Ponce中心的Rana Chakraborty博士与传染病科和埃默里疫苗中心的Rengarajan博士之间的密切合作，并利用了两个小组现有的临床和基础科学专业知识和基础设施。通过这些探索性研究产生的数据将为未来关于新生儿疫苗诱导免疫的详细研究奠定基础。