Women's Interagency HIV Study (WIHS) IV, Chicago Consortium

描述（由申请人提供）：WIHS是一项多地点前瞻性流行病学队列研究，研究对象是1994年和2002年入组的感染艾滋病毒或感染艾滋病毒风险增加的妇女。该研究的目的是继续对WIHS队列进行随访，从而支持对具有代表性的，主要是少数民族的美国成年妇女的自然和治疗HIV感染史的研究，以及支持与长期HIV感染和治疗相关的新问题的研究。《艾滋病信息系统-第四期》的科学举措将包括正在进行的核心研究项目和启动新的项目，内容涉及对抗逆转录病毒治疗的反应和艾滋病毒感染和艾滋病毒治疗的长期后果的预测因素，包括心血管疾病、肝病、激素功能、神经认知障碍、癌症和其他发病率，以及发展为艾滋病和死亡。此外，在WIHS-IV资助周期内，科学合作将继续扩大独立的、研究者驱动的研究资助。

DESCRIPTION (provided by applicant): The WIHS is a multi-site prospective epidemiology cohort study of women enrolled in 1994 and 2002 who either are infected with HIV or are at increased risk for acquiring HIV infection. The purpose of the study is to continue follow-up of the WIHS cohort, thereby supporting studies of the natural and treated history of HIV infection in representative, primarily minority, adult women in the United States, as well as supporting studies of emerging questions related to long-term HIV infection and treatment. WIHS-IV scientific initiatives will include ongoing core research projects and the initiation of new projects on the predictors of response to antiretroviral therapy and long term consequences of HIV infection and HIV therapy in terms of cardiovascular disease, liver disease, hormonal function, neurocognitive impairment, cancer and other morbidities, as well as progression to AIDS and death. Additionally during the WIHS-IV grant cycle scientific collaborations will continue to expand independent, investigator-driven research grants. As an ongoing cohort study that, The Chicago site will continue to support the overall WIHS scientific research agenda by continuing to collect quality data and specimens from participants and maintain superb cohort retention. The Chicago site will also provide leadership for key areas of interest including HIV virology and host immunology, long term pathogenesis of HIV infection and treatment toxicities, and impact of viral resistance. Topics of study will include the effect of co-infections such as hepatitis C (HCV) and B virus (HBV), human papillomavirus (HPV); therapy use and treatment effects in women, behavioral and psychosocial factors influencing HIV disease, effects of metabolic abnormalities, impact of hormonal factors on HIV disease; the effects of aging and menopause on HIV disease, the interaction of environmental and host genetic factors on HIV disease; and the assessment of brain structure, neurocognitive functioning, and physical impairment among WIHS participants.